Name: MI-888 free base
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT220913753
Cas No:
常用名:MI-888 free base
IUPAC:(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-N-[(1r,3s)-3-hydroxy-3-methylcyclobutyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
IUPAC:(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-N-[(1r,3s)-3-hydroxy-3-methylcyclobutyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
InChI key:InChIKey=MZBOZBMARIQZGX-GRRGFIRHSA-N

分子式:C28H32Cl2FN3O3
分子量:548.48
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@@](C)(O)C1
SMILES:CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@@](C)(O)C1

MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.

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