Name: AZD5718
Rating: 5 (10 reviews)

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HIT ID:HIT220913810
Cas No:2041076-43-9
常用名:AZD5718
IUPAC:(1R,2R)-2-{4-[3-methyl-1-(oxan-2-yl)-1H-pyrazol-5-yl]benzoyl}-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide
IUPAC:(1R,2R)-2-{4-[3-methyl-1-(oxan-2-yl)-1H-pyrazol-5-yl]benzoyl}-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide
InChI key:InChIKey=STCBLTCFJMDESY-QQMHWKEJSA-N

分子式:C29H34N6O4
分子量:530.629
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cc(-c2ccc(cc2)C(=O)[C@@H]2CCCC[C@H]2C(=O)Nc2cnn3CCNC(=O)c23)n(n1)C1CCCCO1
SMILES:Cc1cc(-c2ccc(cc2)C(=O)[C@@H]2CCCC[C@H]2C(=O)Nc2cnn3CCNC(=O)c23)n(n1)C1CCCCO1

AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Preclinical toxicology studies in rat and dog did not show any serious adverse events of clinical significance. Currently, AZD5718 is evaluated in a phase 2a study for treatment of coronary artery disease.

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