ADC Cytotoxin

Maytansinol (GMP) refers to the GMP grade reagents of Maytansinol. Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.

Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is an ADC (Antibody Drug Conjugate) toxin.

Exatecan Intermediate 4 (compound B) is an intermediary in the synthesis of Exatecan (DX-8951), a chemotherapeutic agent classified as a camptothecin analogue. It acts by interacting with DNA to disrupt the proliferation and division of tumor cells, thereby inhibiting tumor growth. Exatecan is primarily researched for its potential application in the treatment of various cancers, including ovarian, lung, and breast cancer.

Ansamitocin P-3 (GMP) refers to the GMP grade reagents of Ansamitocin P-3. Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC₅₀ of 3.4 μM for tubulin polymerization.

Exatecanintermediate 9 is an intermediate used in the synthesis of Exatecan. Exatecan (DX-8951) is a common toxin component in the preparation of Antibody-Drug Conjugates (ADC Cytotoxin) and also acts as an inhibitor of DNA topoisomerase I (topoisomerase I), with an inhibition concentration (IC₅₀) of 2.2 μM.

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.

Glucocorticoid receptor agonist-2 (compound 21), a glucocorticoid receptor agonist with an IC₅₀ value of 6.6 nM, serves as an active reference for ABBV-3373 [1] and is instrumental in the synthesis of anti-inflammatory ADC molecules.

Nucleoside Derivatives - Fluoro-modified nucleosides; 5-Modified pyrimidine nucleosides; 3'-Deoxy nucleosides

10-Methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from *Camptotheca acuminata*, exhibits potent anti-cancer properties.

Benzyl DC-81 (Compound 6a), an anticancer agent, exhibits antiproliferative activity against A375 and MCF-7 cells [1].

Tubulysin E is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide.

Fmoc-MMAF-OMe is a tubulin polymerization inhibitor and anticancer agent featuring an Fmoc protecting group. Its active component, MMAF, serves as the cytotoxic (ADC Cytotoxin) element in conventional antibody-drug conjugates (ADCs) [1].

PNU-159682 carboxylic acid is a potent ADCs cytotoxin,PNU-159682 carboxylic acid has protein fold and diverse functions.

Luisol A, an aromatic tetraol and anthraquinone antibiotic analog, serves as a significant metabolite produced by an estuarine marine actinomycete from the genus Streptomyces. Additionally, it functions as an ADC (Antibody-Drug Conjugate) cytotoxin [1].

PNU-159682, a metabolite of anthracycline nemorubicin, is a DNA topoisomerase II inhibitor with excellent cytotoxicity.

S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 μM) and inhibits microtubule polymerization.

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

TAM470, a novel cytolysin, inhibits both tubulin polymerization and microtubule depolymerization. It serves as a precursor in the synthesis of OMTX705, a payload molecule. OMTX705 represents a new class of FAP-targeting antibody-drug conjugates (ADCs) exhibiting antitumor activity [1].

Exatecan Analogue 1 (Icp-3), a derivative of Exatecan, is instrumental in the synthesis of antibody-drug conjugates (ADCs) [1].

Bac5(1-25) is the N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5 [1].

STING agonist-35 (Compound 1a) is an agonist for stimulator of interferon genes (STING), activating wild type STING and mutated type STING (R232H) at rates of 99% and 92%, respectively. It is a potent payload for ADC [1].

Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45), a camptothecin derivative, demonstrates potent inhibitory effects on cell proliferation, exhibiting an IC 50 of 2.92 ng/mL against MDA-MB-468 cells. It is primarily utilized in cancer research [1].

Dexamethasone acetate (Standard) is the standard substance of Dexamethasone acetate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.

Corixetan is a potent thorium chelator that effectively forms stable complexes with Th-227 in vivo.

7-MAD-MDCPT hydrochloride, a camptothecin analogue, serves as the active component in antibody-drug conjugates (ADC).

Hydrotecan is an auristatin derivative utilized as an ADC cytotoxin, and it serves as a component in the synthesis of ADC molecules.

Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.

Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.

Azonafide-PEABA is a drug moiety with cytotoxic [1].

Aniline-MPB-amino-C3-PBD is a cytotoxic agent with a non-alkylating group and acts as a sequence-selective DNA minor-groove binding agent.

Top1 inhibitor 1 is a potent inhibitor of human topoisomerase I (Top1)(IC₅₀: 29 nM).

Duocarmycin MB, an antibody-drug conjugate (ADCs) toxin, is a DNA alkylating agent that binds in the minor groove and can be used against multi-drug resistant cell lines.

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.

Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC₅₀s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC₅₀s = 1.1, 72.5, 77, and 24.5 nM, respectively).