三桠苦属

Glaucin B is a new bitter limonoid.

Evodosin A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4044，CAS号为 1291053-38-7。

Flavaprin是一种天然产物，属于芸香科三桠苦属，其产品编号为 TN4061，CAS号为 53846-49-4。Flavaprin可用作对照参考。

1,2,3,4-Tetrahydronorharman-1-one (L-Oxonoreleagnine) 是从印度尼西亚海海绵 Acanthostrongylophora ingens 中分离得到的。

3,5,6-trihydroxysitostane 是一种从吴茱萸果实中提取的类固醇天然产物。

1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification by inhibiting phosphate cotransporter (PiT-1) gene expression. It also shows moderate antiangiogenic activity against human tumor cells.

Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.

7-Isopentenyloxy-gamma-fagarine has highly cytotoxicity against the MCF-7and Jurkat cell line. It has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine.

12alpha-Hydroxyevodol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2604，CAS号为 120722-04-5。

Stigmastane-3,5,6-triol and derivatives could be used for preparing antiviral medicine.

1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.

(2S,3S,4R,2'R)-2-(2'-hydroxytetracosanoylamino)octadecane-1,3,4-triol shows selectively inhibitory activity against phospholipase A 2 (PLA 2) secreted from Crotalus adamenteus venom at concentration of 100 ug/mL.

6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.

Hydroxyevodiamine is a natural product

Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。

Evodol may as an anti-inflammatory agent or lead compound, it shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages. Evodol and limonin possess larvicidal activity against the Asian tiger mosquitoe

1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.

5-Methoxy-2',3'-dehydromarmesin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2673，CAS号为 54087-32-0。

Dihydroevocarpine（二氢吴茱萸卡品碱）在急性髓性白血病（AML）异种移植模型中，通过抑制mTORC1/2活性和mTOR通路，诱导AML细胞毒性、凋亡和G0/G1阻滞、抑制肿瘤生长。

Dehydroevodiamine hydrochloride 是分离自吴茱萸叶中，能够抑制 AChE。 它能够调节一氧化氮的产生，具有降压和神经保护作用。

1-Methyl-2-pentyl-4(1H)-quinolinone（1-甲基-2-戊基-4(1H)-喹啉酮）是一种含有喹啉结构的天然产物，是一种特异性的疟原虫（Plasmodium falciparum）II型NADH脱氢酶（PfNDH2）的特异性抑制剂，显著抑制疟原虫在蚊子阶段的发育，具有阻断疟疾传播的作用和低毒性的特点。

Evodine 是吴茱萸中的主要柠檬苦素，是P-gp 有效抑制剂，可通过保留抗氧化剂防御系统，针对谷氨酸诱导的毒性具有保护作用。