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化合物库
Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
Influenza Virus
Integrase
Parasite
Penicillin-binding protein (PBP)
RSV
Reverse Transcriptase
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ribosome
信号通路
微生物学
Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT107500764
Luvangetin
TN4465
483-92-1
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced
Antifection
COX
Prostaglandin Receptor
HIT213885943
Methyl 3-O-feruloylquinate
TN4531
154418-15-2
Methyl 3-O-feruloylquinate inhibits the activity of bacteria and viruses and to regulate immunity.
Antifection
HIT213884561
7-Angeloylretronecine
TN3221
6029-82-9
7-Angeloylretronecine may have antibacterial effects.
Antifection
HIT213885021
7',8'-Dihydroobolactone
TN3220
1240403-82-0
7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
Antifection
HIT213884616
Isocostic acid
TN4274
69978-82-1
Isocostic acid may have antibacterial activity.
Antifection
HIT213885771
Kielcorin
TN4388
64280-48-4
Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
Antifection
HIT213887191
Labd-13-ene-8,15-diol
TN4402
10267-31-9
13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer ac
Antifection
HIT213885595
Coronarin E
TN3710
117591-81-8
Coronarin E exhibits weak antimicrobial activity.
Antifection
HIT214315796
Cycloart-23-ene-3,25-diol
TN3735
14599-48-5
Cycloart-23-ene-3,25-diol has anti-inflammatory activity, it has protective activity against streptozotocin induced toxicity. Cycloart-23-ene-3,25-diol treatment can decrease liver malondialdehyde but increase superoxidase dismutase and reduced glutathion
Antifection
HIT212665959
Torachrysone
TN2278
22649-04-3
Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-
Antifection
HIT213885906
Isocudraniaxanthone B
TN4276
199851-52-0
Isocudraniaxanthone B may have antimalarial activity.
Antifection
Sodium Channel
HIT213884918
Evofolin C
TN4045
163634-05-7
Evofolin C and its acetate show strong antifungal and antibacterial activity. Evofolin C exhibits potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
Antifection
HIT213885781
Pterodontic acid
TN4852
185845-89-0
Pterodontic acid and pterodondiol showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis.
Antifection
HIT213884784
Cannabispirol
TN3580
64052-90-0
Cannabispirol has a weak antibacterial effect which is more definite on plasmid carrying bacteria than plasmidless ones, and inhibits intercellular plasmid transfer and transforming activity of plasmid DNA.
Antifection
HIT213887157
4-Epialyxialactone
TN3027
132339-37-8
4-Epialyxialactone exhibits significant antitumor and antibacterial activity.
Antifection
HIT213884424
2,6-Dimethoxy-1-acetonylquinol
TN2738
2215-96-5
2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.
Antifection
HIT213886833
Stilbostemin N
TN5071
1000676-45-8
Stilbostemins N may exhibit moderate antibacterial activities.
Antifection
HIT213885255
3-O-trans-p-Coumaroyltormentic acid
TN2977
121064-78-6
3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).
Antifection
Caspase
HIT105366410
Calceolarioside A
TN3568
84744-28-5
Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi
Antifection
Calcium Channel
HIV Protease
HIT212687408
Rengynic acid
TN4906
517883-38-4
Rengynic acid has potent antiviral effect on RSV for the first time in vitro.
Antifection
RSV
HIT213884502
14-Deoxy-17-hydroxyandrographolide
TN2623
869384-82-7
14-Deoxy-17-hydroxyandrographolide是一种天然产物,属于爵床科穿心莲属,其产品编号为 TN2623,CAS号为 869384-82-7。14-Deoxy-17-hydroxyandrographolide可用作对照参考。
Antifection
Others
HIT218850842
11-Oxomogroside II A1
T75566
942612-74-0
11-Oxomogroside II A1(化合物 7)是一种从罗汉果乙醇提取物中分离的氧化葫芦苷,对12-O-十四烷酰基激素-13-乙酸酯(TPA)诱导的Epstein-Barr病毒(EBV)早期抗原(EBV-EA)活化具有抑制效果,并对一氧化氮(NO)供体(+/-)-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺(NOR 1)的活化也展示出轻微的抑制作用。
Antifection
Others
HIT214315781
Chrysothol
TN3650
911714-91-5
Chrysothol shows strong antimicrobial activities (MICs=50-100 ug/ml) against enterobacteria E. coli and S. enteritidis. It also shows anti-cancer activity against human breast cancer cells.
Antifection
HIT213885795
Anisofolin A
TN3422
83529-71-9
Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis.
Antibacterial
Antifection
Parasite
HIT213884433
Erythrocentaurin
TN4010
50276-98-7
Erythrocentaurin has antibacterial activity; it also exhibits a concentration-dependent α-amylase inhibition (IC(50) 1.67 ± 0.28 mg/mL).
Antifection
HBV
HIT212732470
Grifolic acid
TN4167
80557-12-6
Grifolic acid is a natural carbonic anhydrase Ⅱ inhibitor(CAⅡ), it shows in-hibitory activities against CAⅡ with IC50 of 6.37 umol/L. Grifolic acid has antibacterial activity, it can inhibit the growth of Staphylococcus aureus and Staphylococcus epidermid
Antifection
GPCR
HIT105958076
EBNA1-IN-SC7
T62921
324022-08-4
EBNA1-IN-SC7 (compound SC7) 是一种 Epstein-Barr nuclear antigen 1 (EBNA1) 的选择性抑制剂,能够干扰 EBNA1-DNA 结合活性 (IC50: 23 μM)。EBNA1-IN-SC7 能够用于研究 EBV (Epstein-Barr virus) 相关癌症。
Antifection
Others
HIT214315952
Homopterocarpin
TN4223
606-91-7
Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property
Antifection
Monoamine Oxidase
HIT214316104
Phaseollidin hydrate
TN4760
76122-57-1
Phaseollidin hydrate shows less antifungal activity than the original phytoalexin phaseollidin.
Antifection
Antifungal
HIT212665843
Quassin
TN2120
76-78-8
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.
Antifection
Parasite
HIT211998617
Econazole nitrate
T0444L
24169-02-6
Econazole nitrate (NSC-243115) 是一种有抗菌活性的咪唑类抗真菌药物。
Antibacterial
Antibiotic
Antifection
Antifungal
HIT101758348
Torachrysone-8-O-b-D-glucoside
TN2277
64032-49-1
Torachrysone-8-O-b-D-glucoside 可从 Polygonum multiflorum 分离得到。它对 DPCs(真皮乳头细胞)的增殖具有促进作用。
Antifection
HIT214316158
Rupesin E
TN4927
924901-58-6
Rupesin E shows significant antibacterial activities against Escherichia coli.
Antibacterial
Antifection
HIT104123923
Dehydroabietic acid
TCS1772
1740-19-8
Dehydroabietic acid (Dehydroabietate) 是 EBV-EA 活化抑制剂。 它是食物衍生化合物,可通过降低血浆葡萄糖、胰岛素水平、血浆甘油三酯 (TG) 和肝 TG 水平来治疗肥胖相关疾病。它的衍生物在动物模型中表现出抗分泌和抗胃蛋白酶作用。
Antibacterial
Antibiotic
Antifection
Antifungal
PPAR
HIT218851907
Lactoferrin (17-41) (Standard)
TMSM-1421
146897-68-9
Lactoferrin (17-41) (Standard)是一种可用于分析的标准物质,通常用作Lactoferrin (17-41)的研究和分析中参考的标准样品。Lactoferrin (17-41)对革兰氏阳性和革兰氏阴性细菌、病毒、和真菌等微生物具有广谱的抗菌活性。
Antibacterial
Antifection
Antifungal
HIT213887313
14-Norpseurotin A
TN2626
1031727-34-0
14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , r
Antifection
Endogenous Metabolite
Others
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