靶向给药系统

DSPE-NHS 是一种脂质，常和其他化合物一起制成纳米乳液，可用在护肤品和药品中。

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) 是一种磷脂酸乙醇胺 (PE) ，能够用于合成脂质体。

DOPE-GA 可用于制备脂质体，用于药物递送的研究。

18:0 DAP 可用于制备脂质纳米粒 (LNPs)，mRNA 被包裹在其核心。

2-Stearoyl-rac-glycerol是一种天然产物和单甘油酯，是小鼠和大鼠中的内源性代谢物。

DLin-K-C3-DMA是一种阳离子脂质，能够结合带负电的mRNA和siRNA，常用于合成脂质纳米粒(LNP)从而递送核酸。

Glycol chitosan 是具有亲水性乙二醇支链的壳聚糖衍生物。它抑制大肠杆菌，金黄色葡萄球菌和肠炎链球菌的生长，MIC 值分别为 4 μg/mL，32 μg/m L 和 <0.5 μg/mL。它可增强 Glycine max Harosoy 63W 细胞的膜通透性和渗漏。

DLIN-MC4-DMA 是一种脂质膜，是一种潜在的核酸载体。

L-Dilinoleoyllecithin is phosphatidylcholine. It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site.

Lipid 6是一种可电离的氨基脂质，适用于合成脂质纳米颗粒。

D-Lin-MC3-DMA 是一种递送 siRNA 载体，是一种可离子化的氨基脂质类化合物。

SM-102是目前临床批准用于 RNA 疗法的唯一可电离的氨基阳离子脂质，可用于合成脂质纳米粒子(LNPs)，它在开发用于运输基于 mRNA 的疫苗的LNPs方面展现出潜力。

DODAP是一种具有低细胞毒性和高转染效率的离子性阳离子脂质，可用于合成脂质体并包裹生物活性分子，如mRNA， siRNA和质粒DNA。

G0-C14 是一种阳离子脂质样分子，常用于合成纳米颗粒和疫苗递送。

L319 (Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate) 是一种脂质膜，是一种潜在的核酸载体。

Thiamphenicol palmitate is a Prodrug of Thiamphenicol, inhibiting the 50S subunit of the bacterial ribosome and protein translation.

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) 是一种磷脂酰乙醇胺，能提高恶性胸膜间皮瘤细胞的PP2A和PTP1B活性，并诱导NCI-H28恶性胸膜间皮瘤细胞凋亡 (apoptosis)。

cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and the digestive gland of P. globosa. It is a component of S. aureus cell membranes and levels decrease upon treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner.

Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.

Tripelargonin is a triacylglycerol that contains nonanoic acid at the sn-1, sn-2, and sn-3 positions. It has been found in Schizochytrium biomass.1 Tripelargonin increases blood levels of the ketone body D-(-)-3-hydroxybutyrate in newborn rhesus monkeys.2

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for δ9-THC.

Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.

OF-Deg-Lin，一种电离性氨基脂质，适用于脂质纳米颗粒的合成。

GL67 (N4-Spermine cholesteryl carbamate)为一种阳离子脂质，用于核酸活性分子、疫苗的递送及基因转染。

OF-02 是一种可电离的脂质，可在体内高效传递 mRNA。

6-Oxohexyl 2-hexyldecanoate 是一种脂质产品 (lipid product)，可用于药物递送。

ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) 显示出高效激活卵磷脂：胆固醇酰基转移酶（LCAT）的功能，适用于合成肽/脂质复合物。

Gal-C4-Chol 是一类糖基化胆固醇衍生物，用作去唾液酸糖蛋白受体 (ASGPR) 的配体，用于制备半乳糖化脂质体。Gal-C4-Chol 还可用于制备简单的脂基纳米颗粒。

4A3-Cit 是一种用于生成脂质纳米颗粒 (LNPs) 的可电离脂质。

Fmoc-L-Trp(Boc)-OH 是一种带保护基团的氨基酸衍生物，具有自组装和形成纳米颗粒的能力，可应用于抗癌药物输送研究。