Others

The use of costic acid and other components from the plant Dittrichia viscosa (Greek: aconiza) and related species for the preparation of acaricidal products used against the acari Varroa destructor as parasite of the honey bee.

Jaceidin triacetate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4344，CAS号为 14397-69-4。

5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.

Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker commonly employed for synthesizing PROTACs[1].

Massarilactone H 是一种聚酮化合物，是神经氨酸酶抑制剂，IC50值为 8.18 µM。

Rucaparib (AG014699) acetate is a highly effective oral inhibitor of PARP proteins, specifically targeting PARP-1, PARP-2, and PARP-3, with a Ki value of 1.4 nM for PARP1. Additionally, it exhibits inhibitory action on hexose-6-phosphate dehydrogenase (H6PD) to a moderate extent. Rucaparib acetate shows promise in the field of research for castration-resistant prostate cancer (CRPC). [1] [2] [3] [4]

Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorde

PHA-543613 hydrochloride acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia.

Sunepitron is a combined α2-adrenergic receptor antagonist and 5-HT1A receptor agonist.

hCAXII-IN-3 (Compound 6o) 是人碳酸酐酶 XII（hCAXII）的选择性抑制剂 (Ki: 10.0 nM)。

A2A/A1 AR antagonist-1 (compound 1a) 具有用于缺血性卒中研究的潜力，它是 A2A/A1AR 的双重拮抗剂，Ki 值分别为 5.58 和 24.2 nM。

Axinelline A 是一种有效的 COX 抑制剂，对 COX-2和 COX-1的IC50分别为 2.22 μΜ 和 8.89 μM。Axinelline A 显示抗炎活性。

Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases.

PI3Kγ inhibitor 4 是一种选择性的、有效的、口服具有活力的 PI3Kγ 抑制剂 (IC50: 40 nM)。PI3Kγ inhibitor 4 对 PI3Kγ 的选择性是 α 亚型的~7 倍、是 β 亚型的 43 倍、是 δ 亚型的 18 倍。PI3Kγ inhibitor 4 能够用于研究气道炎症。

N6-Methyl-xylo-adenosine is a Nucleoside Derivative - Xylo-nucleoside;6-Substituted purine nucleoside.

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid.

Betamethasone acibutate, a glucocorticoid, is derived from Betamethasone.

G0507 is a pyrrolopyrimidinedione compound that serves as a potent inhibitor of Escherichia coli growth, effectively inducing the extracytoplasmic σE stress response. It acts as a valuable chemical probe, specifically designed to dissect lipoprotein trafficking in Gram-negative bacteria. Notably, G0507 demonstrates strong inhibitory activity against the LolCDE ABC Transporter.

HSP90-IN-14 (compound 4) 是有效的Hsp90 抑制剂（Kd= 0.26μM）。在MDCK 细胞中，HSP90-IN-14 表现出抗流感病毒活性，抗 A/H3N2、A/H1N1 和 B 型流感病毒的EC50分别为 2.6、3.9 和 17 μM。

NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.

Alimemazine hemitartrate (Trimeprazine hemitartrate) 是血凝素 (HA)-受体的拮抗剂，也是一种吩噻嗪衍生物，常用作止痒剂。

Etamivan (Ethamivan) 是口服有活性的呼吸激活剂，常用于研究巴比妥类药物过量与慢性阻塞性肺疾病。

Protein kinase G inhibitor-2 具有抗菌、抗病毒和抗肿瘤活性。

ERK5-IN-3 是选择性的、有效的 ERK5 (细胞外信号相关激酶 5) 抑制剂 (IC50: 6 nM)。ERK5-IN-3 对 Hela 细胞表现出抗增殖作用 (IC50: 31 nM)。

MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.

RSV-IN-3 (Compound 1) 是呼吸道合胞病毒 (RSV) 和流感病毒 A (IAV) 的双重抑制剂。RSV-IN-3 具有抗 RSV 活性 (EC50=32.70 μM)。

FmocNH-PEG4-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Indolapril hydrochloride is a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity.

α-Methyl-trans-cinnamaldehyde是一种不饱和醛，广泛应用于生物化学实验和药物合成研究。

Aldehyde Reactive Probe TFA (ARP TFA) 是一种醛反应探针，用于检测植物 mRNA 中脱碱基位点的水平。

PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1].

R-(+)-Cotinine ((+)-Cotinine) 是一种尼古丁代谢物，在广泛的药理靶标中缺乏显着活性。R-(+)-Cotinine 可以增强人 α7nAChR 中的 Ach 诱发电流。

Imidazol-1-yl-acetic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T67657，CAS号为 22884-10-2。

CFM-5 具有抗惊厥活性，可用于研究癫痫。

Olaparib (Standard) 是一种可用于分析的标准物质，通常用作 Olaparib 的研究和分析中参考的标准样品。Olaparib (KU0059436) 是 PARP1/PARP2 的小分子抑制剂 (IC50=5/1 nM)，对 PARP tankyrase-1 的抑制活性较弱 (IC50=1.5 μM)，具有选择性和口服活性。Olaparib 具有自噬和线粒体自噬激活活性。