Others

Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds to the IAP ligand with the assistance of a linker, resulting in the formation of SNIPER[1].

2-Keto Crizotinib is an active lactam metabolite of crizotinib.

Azido-PEG8-C1-NHS ester is a polyethylene glycol (PEG)-based linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

JG-258 是一种Hsp70抑制剂的无活性阴性对照。

AKR1B10-IN-1, a powerful AKR1B10 (Aldo-Keto Reductase 1B10) inhibitor, demonstrates an IC50 value of 3.5 nM. This compound effectively curtails the proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.

LSN2814617 是一种口服有效的、能透过血脑屏障的和选择性的mGlu5(代谢性谷氨酸 5) 正向别构调节剂 (PAM)，其EC50值为 52 nM (Human mGlu5) 和 42 nM (rat mGlu5)。体内EGG 研究表明，LSN2814617 具有显著的促醒作用，并且几乎不会反弹过度嗜睡，可用于精神分裂症研究。

(S)-Baxdrostat is an S-enantiomer of Baxdrostat, which functions as an inhibitor of aldosterone synthase [1].

Bromo-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Testosterone-d3（睾酮-d3）是Testosterone氘代标记化合物，可用于同位素示踪。Testosterone是男性的主要性激素和雄激素。

Bopindolol ((±)-Bopindolol) fumarate 是一种具有部分激动剂活性的、口服具有活力的 β-肾上腺素受体 (ARs) 拮抗剂，对 β1- 和 β2-ARs 无选择性，对 β3-AR 亚型亲和力低。Bopindolol fumarate 是 Pindolol 的前体药物，能够用于研究原发性和肾血管性高血压。

5-[Boc(methyl)amino]pentanal 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64598。

Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.

YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) r

Fmoc-NH-pentanoic acid-NHS-SO3Na is a PROTAC linker molecule derived from an alkyl chain. It possesses the ability to facilitate the synthesis of PROTACs[1].

Nampt-IN-9 (Compound 8) 是一种有效的 NAMPT 抑制剂，具有抗癌作用。Nampt-IN-9 能够用于研究胰腺导管腺癌。

UBP141 is a antagonist of N-methyl-D-aspartate (NMDA) receptor.

11β-HSD1-IN-7 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67622，CAS号为 728-86-9。

Resolvin D3 (RvD3) is a dysregulated mediator originating from docosahexaenoic acid (DHA). It plays a crucial role in reducing arthritic inflammation.

2'-Deoxy-2'-fluoro-N4-benzoyl-5-methylcytidine is a Nucleoside Derivative - Fluoro-modified nucleoside, 5-Modified pyrimidine nucleoside, 2'-Modified nucleoside.

Thieno[2,3-b]thiophene（噻吩[2,3-B]噻吩）是一种噻吩，可用于有机光电材料和生化实验。

Thiol-C9-PEG5 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tilomisole (Wy 18251) 是一种可口服的苯并咪唑噻唑，具有抗炎活性和免疫调节活性。Tilomisole 可用于研究癌症和炎症。

3-Amino-2-methylpropanoic acid (Standard) 是一种可用于分析的标准物质，通常用作 3-Amino-2-methylpropanoic acid 的研究和分析中参考的标准样品。3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物，是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。

Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.

Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2].

Dysolenticin J shows significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 ug/mL.

ICMT-IN-27（化合物64）作为ICMT抑制剂，具有0.1 μM的IC50值。

TY-51469是糜蛋白酶 (chymase) 抑制剂，在类人猿和人糜蛋白酶的 IC50 值分别为0.4和7.0 nM。

PHGDH-inactive 对 PHGDH 无活性，IC50大于57 μM，可用作 NCT-502 和 NCT-503 的阴性对照。

CETP-IN-4 is a cholesteryl ester transfer protein (CETP) inhibitor.

2α-Methyl androsterone is an anabolic androgenic steroid metabolite of mesterolone and drostanolone.

Pimobendan hydrochloride is a selective inhibitor of PDE3 (IC50: 0.32 μM).

Coumarinic acid为具有脑穿透性的双重功能抑制剂，能够抑制AChE和β-amyloid，适用于开发治疗阿尔茨海默病的药物研究。

5'-homocytidine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU1672，CAS号为 55085-34-2。

Naldemedine tosylate (S-297995)为具口服活性的μ-阿片受体拮抗剂(PAMORA)。其对重组人源μ-、δ-及κ-阿片受体展现出高亲和力(Ki分别为0.34，0.43，0.94 nM)及强拮抗效果(IC50分别为25.57，7.09，16.1 nM)。适用于研究由阿片类物质引起的便秘(OIC)。Naldemedine tosylate也被预测可能与SARS-CoV2 3CLpro结合。

TK4g is a potent Janus kinase (JAK) inhibitor, demonstrating IC50 values of 12.61 nM and 15.80 nM against JAK2 and JAK3, respectively. It holds promise for research focused on lymphoid-derived diseases and leukemia cancer [1].