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供应商货号
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HIT ID
供应商货号
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Others
Advanced Glycation End Products
CYP19A1
Decarboxylase
DprE1
Fer/FerT kinase
Platelet aggregation
Progesterone Receptor
Others
信号通路
其他
Others
Others
Targetmol为生命科学及医药领域的科研人员提供其他未细分细胞信号通路相关产品,包括抑制剂、激动剂、调节剂、降解剂等。
HIT213840408
Sulfobromophthalein disodium salt
TD0105
71-67-0
Sulfobromophthalein disodium salt 是一种有机阴离子染料,能够参与药物和代谢物的运输,可用于研究动物组织中表达的多种膜载体。
Others
HIT212665498
Genistein 7,4'-di-O-β-D-glucoside
TN1679
36190-98-4
Genistein 7,4'-di-O-β-D-glucoside是一种天然产物,在MCF-7细胞中具有纳摩尔级别的雌激素增殖作用,可用于研究骨质疏松。
Others
HIT212667658
DSPE-PEG5-azide
T17865
2112737-73-0
DSPE-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Others
PROTAC Linker
HIT212731326
L-Xylulose
T71809
527-50-4
L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs.
Endogenous Metabolite
Others
HIT214322655
Sel-green
T39048
1574299-37-8
Sel-green is a selective selenol fluorescent probe used for quantifying the selenocysteine (Sec) content in the selenoenzyme thioredoxin reductase, as well as imaging endogenous Sec in live HepG2 cells.
Others
HIT212668446
Thiol-PEG10-alcohol
T18835
Thiol-PEG10-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Others
PROTAC Linker
HIT217583420
NV-354
T81631
866465-21-6
Mitochondria modulator-1为线粒体调节剂,可促进ATP生成。该化合物展现出优良的口服生物利用度、血脑屏障透过性及稳定的血浆稳定性,展现出其研究线粒体疾病的潜力。
Others
HIT219469213
ZC0109
T73512
ZC0109 是 IDO1和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂,IC50分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累,使细胞周期阻滞于 G1/S 期,导致癌细胞凋亡 (apoptosis)。
Apoptosis
IDO
Indoleamine 2,3-Dioxygenase (IDO)
Others
HIT217591372
Y13g
T60739
2766380-73-6
Y13g 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂, 这两个靶点阿尔茨海默症 (AD) 进展的有关。Y13g 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。
Cholinesterase (ChE)
Interleukin
Others
HIT214315341
Mcl-1 antagonist 1
T11967
2376775-05-0
Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.
Bcl-2 Family
Others
HIT213840504
Pomalidomide-C6-COOH
T40001
2225940-50-9
Pomalidomide-C6-COOH 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于 Pomalidomide 的 CRBN 配体和接头。
E3 Ligase Ligand-Linker Conjugates
Others
HIT212671669
Vitamin D4
T19602
511-28-4
Vitamin D4 is the active Vitamin D analog.
Others
Vitamin
HIT214317241
11β,13-Dihydrotaraxinic acid
TN6254
1274668-83-5
11β,13-Dihydrotaraxinic acid 是一种天然存在的小分子代谢物,被鉴定为适用于生命科学和生物化学研究的生物活性化合物。该化合物主要作为参考品或研究级材料,用于天然产物化学、代谢通路分析、生物活性筛选以及药理学、生物化学或分子生物学领域中的实验验证研究,尤其适用于需要结构明确的植物来源化合物的研究体系。
Others
HIT212686682
(R)-NVS-ZP7-4
T12634
2517682-14-1
(R)-NVS-ZP7-4 是 NVS-ZP7-4 的 R 型异构体。 NVS-ZP7-4 是一个报道用于探测内质网锌水平影响的化学分子,是一种锌转运体 SLC39A7(ZIP7)的抑制剂,并研究 ZIP7 作为 Notch 通路中的一种新的可成药节点。
Others
HIT214433637
5-HT6/5-HT2A receptor ligand-1
T61207
2411088-07-6
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in neurological and psychiatric disorders [1].
5-HT Receptor
Others
HIT211998750
Ulifloxacin
T65577
112984-60-8
Ulifloxacin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65577,CAS号为 112984-60-8。
Antibacterial
Antibiotic
Others
HIT214434479
3'-beta-C-Ethynyluridine
TNU0475
180300-49-6
3'-beta-C-Ethynyluridine is a Nucleoside Derivative - 3'-Modified nucleoside.
Nucleoside Antimetabolite/Analog
Others
HIT212671408
HIV-1 integrase inhibitor 3
T11567
1638504-56-9
HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM).
HIV Protease
Others
HIT212713070
Levoprotiline hydrochloride
T27820
76496-69-0
Levoprotiline hydrochloride is an antidepressant.
Adrenergic Receptor
Others
HIT214323927
Erythromycin A dihydrate
T40676
59319-72-1
Erythromycin dihyrate dihydrate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin dihyrate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.
Antibacterial
Antibiotic
DNA/RNA Synthesis
Others
HIT214322650
Propanol-PEG4-CH2OH
T39041
156868-17-6
Propanol-PEG4-CH2OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Others
PROTAC Linker
HIT212668695
Biotin-PEG5-azide
T14604
1163732-89-5
Biotin-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Others
PROTAC Linker
HIT212667933
Mal-NH-PEG12-CH2CH2COOPFP ester
T18254
2136296-33-6
Mal-NH-PEG12-CH2CH2COOPFP ester is a polyethylene glycol (PEG) based linker molecule, designed specifically for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
Others
PROTAC Linker
HIT219574091
2,2',3,4,4',5'-PCB in Cyclohexane (Standard)
TMIM-00071
35065-28-2
2,2',3,4,4',5'-PCB in Cyclohexane (Standard)是2.2'3.4.4'5'-六氯联苯溶于环己烷的标准品溶液,可用作分析标准品。
Others
HIT212709699
Beloranib
T19871
251111-30-5
Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.
Aminopeptidase
Others
HIT212035910
LY 2886721 Hydrochloride
T37661
1262036-49-6
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
Beta-Secretase
Others
HIT214435656
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine
TNU1161
2095417-60-8
5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)uridine is a Nucleoside Derivative - 5'-Modified nucleoside; Azido-nucleoside; 2'-Modified nucleoside.
Nucleoside Antimetabolite/Analog
Others
HIT214434401
FXR antagonist 1
T64144
2295804-68-9
FXR antagonist 1 是一种选择性的、口服具有活力的肠道 FXR 拮抗剂,其 IC50 值为 2.1 μM。FXR antagonist 1 能够拮抗肠道 FXR,并反馈激活肝脏 FXR,进而选择性地抑制肠道 FXR 信号。FXR antagonist 1 可改善 NASH (非酒精性脂肪性肝炎) 模型中的肝脏脂肪变性、炎症和纤维化,能够用于研究 NASH。
FXR
Others
HIT103841176
GPVI antagonist 2
T62250
880399-00-8
GPVI antagonist 2 (Compound 1) 是一种潜在的 Glycoprotein VI (GPVI) 拮抗剂,能够作用于胶原蛋白 (IC50: 0.35 μM)、CRP (IC50: 0.80 μM)、convulxin (IC50: 195.2 μM)、凝血酶 (IC50: 81.38 μM)。其中糖蛋白 VI (GPVI) 是一种血小板主要胶原受体,是有效的、安全的抗血栓研究靶点。GPVI antagonist 2 是一种很有前途的抗血小板药物。
Others
HIT218964234
CB2R probe 1
T74604
2634714-79-5
CB2R probe 1 是一种安全绿色的 CB2R (2 型大麻素受体)荧光探针,Ki 为 130 nM。CB2R probe 1 在癌细胞中显示出低细胞毒性。
Cannabinoid Receptor
Others
HIT104246721
5,5-Dimethyldihydrofuran-2(3H)-one
TN9651
3123-97-5
5,5-Dimethyldihydrofuran-2(3H)-one是一种呋喃衍生物和内酯,广泛应用于生物化学实验和药物合成研究。
Others
HIT214315010
Siomycin A
T12917
12656-09-6
Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.
Antibacterial
Apoptosis
Others
HIT218850781
7-Hydroxyneolamellarin A
T75487
959662-26-1
7-Hydroxyneolamellarin A,一种从海绵Dendrilla nigra 提取的天然产物,是高效的缺氧诱导因子 1α (HIF-1α) 抑制剂。该化合物能够减弱HIF-1α蛋白的积累,并抑制血管表皮生长因子 (VEGF) 的转录活性,因而在癌症研究中有应用价值。
HIF/HIF Prolyl-Hydroxylase
Others
VEGFR
HIT214321313
11-deoxy Prostaglandin F1α
T36771
37785-98-1
11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.
Others
Prostaglandin Receptor
HIT214323002
Relzomostat
T39488
2081078-92-2
Relzomostat is a MetAP2 inhibitor, specifically targeting methionine aminopeptidase 2. It holds potential in research concerning obesity, type 2 diabetes, and other conditions associated with obesity.
Aminopeptidase
Others
HIT213885356
Fischeria A
TN4059
221456-63-9
Fischeria A是一种天然产物,属于大戟科大戟属,其产品编号为 TN4059,CAS号为 221456-63-9。Fischeria A可用作对照参考。
Others
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