Others

SHP2-IN-22 作为变构抑制剂，靶向SHP2，具有 17.7 nM 的 IC50。该化合物能够有效抑制MIA PaCa-2胰腺癌细胞的增殖、迁移和侵袭行为。SHP2-IN-22 主要用于研究含Kirsten大鼠肉瘤病毒癌基因(KRAS)突变型的癌症。

Boc-Aminooxy-PEG2-C2-amine is a polyethylene glycol (PEG)-based linker molecule, intended for use in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged graft survival and abrogated transpla

12β-Hydroxyisocholic Acid (Lagocholic Acid) 是一种胆酸异构体，与胆汁代谢有关，可用于研究代谢疾病。

Phytochelatin 3（植物螯合素PC 3）是一种由谷胱甘肽衍生的多肽和重金属解毒剂/螯合剂, 由3个单位的glu-cys组成。

(-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.

Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity.

Ro 12-5637 is a metabolite of moclobemide.

Veledimex racemate, the racemic form of veledimex, is an orally available, small-molecule ligand that activates the RheoSwitch Therapeutic System.

FPI-1523, a derivative of Avibactam, is a potent inhibitor of β-lactamase enzymes. It has Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. Additionally, FPI-1523 inhibits PBP2 with an IC50 of 3.2 μM and demonstrates significant antimicrobial activity.

3-O-Benzyl-1,2:5,6-di-O-isopropylidene-alpha-D-allofuranose is a Carbohydrate.

Cdc7-IN-14 (compound 82) is a highly potent inhibitor of CDC7, demonstrating an IC50 value of less than 1 nM. This compound, Cdc7-IN-14, exhibits promising potential for cancer research [1].

MK771 is a therapeutic agent and an analog of the Thyrotropin Releasing Hormone (TRH). TRH and its analogs may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects.

WNY1613 是有效的、选择性的 PI3Kδ 抑制剂，具有含有哌嗪酮的嘌呤支架。WNY1613 在体外和体内均具有抗 NHL 作用。WNY1613 能够抑制 NHL 细胞系中 PI3K 下游成分的磷酸化，并可诱导癌细胞凋亡 (apoptosis) 。

CathepsinL/S-IN-1 是 Cathepsin L 和 Cathepsin S 的双重抑制剂，IC50分别为 4.10 μM 和 1.79 μM。CathepsinL/S-IN-1 对胰腺癌 BxPC-3 和 PANC-1 细胞具有显著的抗转移和侵袭作用。

CHO-CH2-PEG1-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019)

Noradrenaline tartrate 一种有效的肾上腺素能受体激动剂，可激活α1、α2和β1受体，是肾上腺素的前体，也是多数交感神经节后纤维及脑内蓝斑核投射系统的主要神经递质，可用于构建心肌病模型。

Sunitinib (Standard) 是一种可用于分析的标准物质，通常用作 Sunitinib 的研究和分析中参考的标准样品。Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶 (RTK) 抑制剂，可以抑制 VEGFR2 和 PDGFRβ (IC50=80/2 nM)。Sunitinib 具有抗肿瘤活性，可以用于治疗肾癌和胃肠道肿瘤。

Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.

Carnaubadiol is a triterpene that has been found in E. corollata and has antiprotozoal activities.1,2 It is active against L. infantum promastigotes and amastigotes, as well as T. cruzi trypomastigotes (IC50s = 46.2, 7.8, and 14.9 μM, respectively).2 |1. Piatak, D.M., and Reimann, K.A. Plant investigations IV. Corollatadiol A new triterpene from euphorbia corollata. Tetrahedron Lett. 13(44), 4525-4528 (1972).|2. de Almeida, B.C., Araújo, B.Q., Carvalho, A.A., et al. Antiprotozoal activity of extracts and isolated triterpenoids of 'carnauba' (Copernicia prunifera) wax from Brazil. Pharm. Biol. 54(12), 3280-3284 (2016).

Drechslerine A is a natural product from the metabolites of the algicolous fungus Drechslera dematioidea.

BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.

Nucleoside Derivatives - Halo-nucleosides, 5'-Modified nucleosides, 2'-Modified nucleosides

Milategrast is a chemical compound that functions as a potent cell adhesion inhibitor and cell infiltration inhibitor. In vitro studies have demonstrated its ability to effectively inhibit the adhesion of Jurkat cells to human fibronectin, with an IC50 value of less than 5 μM.

1,3,5-Trimethoxybenzene (Phloroglucinol trimethyl ether) 是一种中国玫瑰品种中的主要芳香化合物。它在三个连续的甲基化步骤中由间苯三酚(初始前体) 合成。它能够用于缓解紧张等。

Anti-osteoporosis agent-1 (comp 4aa) 作为一种高效的复制蛋白 A(RPA) 抑制剂，表现出其IC50值仅为18 μM。

Methyltetrazine-amido-PEG5-alkyne is a polyethylene glycol (PEG) derivative commonly employed as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].

Cellohexaose，一种由β(1-4)链接的D-葡萄糖单体通过缩合反应形成的葡萄糖聚合物，来源于纤维素的分解，包含两个或更多的葡萄糖单体。

Alfadolone acetate is a gamma-aminobutyric acid (GABA) receptor agonist.

Dixyrazine（UCB 3412） 具有短暂的降压作用，可预防注射硫酸鱼精蛋白引起的脑水肿，可用于研究与神经系统相关的疾病。

Baccatin VI 对对苯并醌诱发的腹部收缩具有显著的抗伤害活性。

3'-Adenylic acid 是一种生物活性化学剂。

(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibitory effects on the nuclear translocation of NF-κB in the connective tissue of the healing area.

Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.

A18-Iso5-2DC18（compound A18）为环状类可电离阳离子脂质，具促进mRNA蛋白表达及诱导强烈介导免疫反应功能。