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Advanced Glycation End Products
CYP19A1
Decarboxylase
DprE1
Fer/FerT kinase
Platelet aggregation
Progesterone Receptor
Others
信号通路
其他
Others
Others
Targetmol为生命科学及医药领域的科研人员提供其他未细分细胞信号通路相关产品,包括抑制剂、激动剂、调节剂、降解剂等。
HIT214313986
5-Bromo-4-chloro-3-indoxyl-beta-D-cellobioside
T60017
177966-52-8
5-Bromo-4-chloro-3-indoxyl-beta-D-cellobioside是用于检测纤维生物水解酶的显色化合物。
Others
HIT106852509
Cholesteryl Acetate
T2918
604-35-3
Cholesteryl Acetate 是胆固醇的羟基被乙酸形式酰化而得到的胆固醇酯。它具有作为人体代谢物的作用。它是一种胆固醇酯和一种乙酸酯。
Endogenous Metabolite
Others
HIT212665468
Frangulin A
TN1649
521-62-0
Frangulin A 保护葡萄叶免受葡萄单胞菌感染,并抑制葡萄藤的生物营养菌丝发育。
Others
HIT215291015
Sinitrodil
T34648
143248-63-9
Sinitrodil (ITF-296) 是一种鸟苷酸环化酶兴奋剂,可用于治疗心肌缺血和心绞痛。
Guanylate cyclase
Others
HIT100911681
AKOS B018304
T5103
6308-22-1
AKOS B018304 是芳基衍生物,能够在para位置进行极性替换。AKOS B018304 是一种基孔肯雅病毒抑制剂.
Antiviral
Others
HIT217664252
1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol
T85207
145134-89-0
1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol 是一种三酰基甘油,其结构特征在于 sn-1 和 sn-2 位置上连接有棕榈酸,在 sn-3 位置上连接有辛酸。棕榈酸,一种广泛存在于动植物体中的长链饱和脂肪酸,已知能够在小鼠颗粒细胞中诱导葡萄糖调节蛋白 78 (GRP78) 与 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。辛酸,作为一种具有微弱腐臭味的油性液体,不仅应用于酯类香料与染料的制备中,还被认为是一种有效的震颤抑制剂。
Others
HIT218638132
10(E),12(Z)-Conjugated Linoleic Acid methyl ester
T85268
21870-97-3
10(E),12(Z)-Conjugated linoleic acid methyl ester serves as a standard for quantifying 10(E),12(Z)-conjugated linoleic acid in L. plantarum culture samples. [Matreya, LLC. Catalog No. 1254]
Others
HIT217656401
5-SAHSA
T84424
2126038-70-6
15-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), is recognized for its involvement in metabolic regulation. This compound comprises stearic acid esterified to 5-hydroxy stearic acid and is notably influenced by dietary changes, such as fasting and high-fat consumption, with a link to insulin sensitivity. SAHSA levels are specifically found to be moderately increased in the serum of AG4OX mice, which are characterized by their glucose tolerance through the overexpression of the Glut4 glucose transporter in adipose tissue. Given the established functions of FAHFAs in enhancing glucose tolerance, prompting insulin secretion, and exerting anti-inflammatory properties, 5-SAHSA emerges as a potential bioactive lipid implicated in the management of metabolic syndrome and inflammation.
Others
HIT218320827
4-Nitrophenyl Palmitate
T85005
1492-30-4
4-Nitrophenyl palmitate serves as a colorimetric substrate for lipase and esterase, enabling the quantification of enzyme activity through the release and colorimetric detection of 4-nitrophenol at 410 nm following enzymatic hydrolysis. This compound facilitates the characterization of enzyme activity across diverse bacterial and mammalian sources, including Burkholderia and porcine pancreatic lipases.
Antibacterial
Others
HIT218543095
JWH 387
T84462
1366067-59-5
JWH 387, a potent analgesic cannabimimetic belonging to the naphthoylindole family, serves as a strong cannabinoid (CB) agonist targeting both central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively. This compound is designed for research and forensic applications.
Others
HIT218832991
Palmitic acid calcium
T84520
542-42-7
Palmitic acid calcium,一种长链饱和脂肪酸,广泛存在于动物和植物中。它能在小鼠颗粒细胞诱导葡萄糖调节蛋白78 (GRP78) 和CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达,可用于建立细胞脂肪变性模型。
Endogenous Metabolite
HSP
Others
HIT218832647
2-O-Ethyl PAF C-16
T84613
78858-42-1
2-O-Ethyl PAF C-16 作为 PAF 的一种同系物,充当 PAF 受体(Platelet-activating Factor Receptor (PAFR))的竞争型配体。它能够阻断 PAF 拮抗剂 WEB 2086 与 PAF 受体的结合,表现出 21 nM 的 IC50 值。
Others
PAFR
HIT212103740
Oleyl alcohol
T87064
143-28-2
Oleyl alcohol 是一种具有多种研究用途的活性化合物。
Others
HIT212732500
5-methoxy EiPT
T84409
850032-66-5
5-Methoxy EiPT, a tryptamine-based designer drug, exhibits structural similarity to 5-methoxy DiPT and 5-methoxy MiPT. Although analytical methods for its identification exist, its biological activity remains unreported. This product is intended for forensic and research applications.
Others
HIT218832870
14S(15R)-EET methyl ester
T85051
110901-52-5
14S(15R)-EET methyl ester, an oxylipin derived from arachidonic acid through cytochrome P450 metabolism, demonstrates specific biological activities. It exhibits affinity for isolated guinea pig monocytes, evidenced by a competitive binding assay with a Ki value of 612.5 nM using [3H]14(15)-EET. This compound notably enhances the dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM), indicating potent vasodilatory effects. Unlike its isomer 14R(15S)-EET, 14S(15R)-EET methyl ester does not inhibit COX activity in enzyme assays or affect isolated platelets, highlighting its distinct functional profile.
Drug Metabolite
Others
HIT217612809
Isopropyl 5-(Diphenylphosphoryl)pentanoate
T84524
2088449-88-9
Latanoprost, the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α, serves as a prodrug for the free acid form, a potent FP receptor agonist in the eye. Isopropyl 5-(diphenylphosphoryl)pentanoate may exist as a potential trace impurity in commercial latanoprost preparations.
Others
Prostaglandin Receptor
HIT218832637
11-deoxy-16,16-dimethyl Prostaglandin E2
T84585
53658-98-3
11-Deoxy-16,16-dimethyl Prostaglandin E2 (11-deoxy-16,16-dimethyl PGE2) is a stable synthetic analog of Prostaglandin E2 (PGE2), acting as an agonist for both EP2 and EP3 receptors. It effectively inhibits gastric acid secretion and ulcer formation in rats, with ED50 values of 1 mg/kg and 0.021 mg/kg, respectively. This compound is also 900 times more potent than Prostaglandin F2α (PGF2α) in inducing contraction of human respiratory tract smooth muscle in vitro.
Others
Prostaglandin Receptor
HIT218645453
Cyclo(L-Leu-L-Trp)
TP2515
15136-34-2
Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite initially derived from Penicillium, exhibiting antibacterial (MICs = 125-1000 µg/ml) and antifungal activities (MICs = 8-64 µg/ml). It also demonstrates antioxidant properties by reducing the production of hydroxy radicals, as evidenced in an electron spin resonance (ESR) spectroscopy assay (IC50 = 1.8 µM). Additionally, Cyclo(L-Leu-L-Trp) has been identified as a bitter compound capable of quickly crossing rat taste cell membranes ex vivo at a 1 mM concentration. Furthermore, it acts as a melatonin receptor agonist in X. laevis melanophores, suppressing cAMP accumulation at a 20 µM concentration, with this effect being negated by the melatonin receptor antagonist luzindole.
Antibacterial
Antifungal
Melatonin Receptor
Others
HIT212731954
O-Desmethyl Metoprolol
T85293
62572-94-5
O-Desmethyl metoprolol, a metabolite of metoprolol, acts as a β1-adrenergic receptor (β1-AR) antagonist. This compound is produced through the metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6.
Drug Metabolite
Others
HIT217694791
LY433771
T84972
220862-64-6
LY433771 is a compound that inhibits the activity of Type X secretory phospholipase A2.
Others
Phospholipase
HIT218543032
1-Palmitoyl-2-Oleoyl-rac-glycerol
T85136
3123-73-7
1-Palmitoyl-2-oleoyl-rac-glycerol, a diacylglycerol, features palmitic acid at the sn-1 position and oleic acid at the sn-2 position. Detected in crude sunflower lecithin, its levels elevate in RINm5F rat insulinoma cells following treatment with oleate, elaidate, or trans-vaccenate.
Others
HIT218832853
(−)-6α-hydroxy Cannabidiol
TN7529
58940-28-6
(−)-6α-Hydroxy Cannabidiol, an analytical reference standard and a phytocannabinoid metabolite, serves primarily as a metabolite of cannabidiol (CBD). This product is designed for use in research and forensic applications.
Cannabinoid Receptor
Others
HIT218832984
trans-J-113863
T84888
202796-42-7
trans-J-113863为一种高效的CCR1及CCR3受体拮抗剂,能够抑制MIP-1α对CCR1的趋化作用和eotaxin对CCR3的趋化作用,IC50值分别为9.57和93.8 nM。
CCR
Others
HIT218615459
Methylcardol triene
TN7547
50423-15-9
Methylcardol triene, a phenolic compound present in cashew nut shell liquid, demonstrates α-glucosidase inhibition (IC50= 39.6 µM) and exhibits schistosomicidal properties by eliminating 100% of adult S. mansoni worms within 24 hours at 100 and 200 µM concentrations. Moreover, it serves as a precursor for synthesizing mono- and bis-benzoxazines.
Glucosidase
glycosidase
Others
Parasite
HIT218638304
13-OAHSA
T84422
1997286-67-5
13-OAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), results from the esterification of oleic acid to 13-hydroxy stearic acid. It represents a significant component of the FAHFA family, most abundantly expressed in the serum of glucose-tolerant AG4OX mice that exhibit adipose tissue-specific overexpression of the Glut4 glucose transporter. Similar to other FAHFAs which are known to enhance glucose tolerance, stimulate insulin secretion, and exert anti-inflammatory effects, 13-OAHSA may play a pivotal role in managing metabolic syndrome and inflammation.
Endogenous Metabolite
Others
HIT212021107
cis-9-Hexadecenol
TCL-00146
10378-01-5
cis-9-Hexadecenol是一种高纯度生化试剂,适合作为生物材料或有机合成中间体,广泛应用于生命科学领域的研究与实验。
Others
HIT217664325
12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol
TYD-02756
344791-14-6
12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol 是一种三酰基甘油,含有两个 sn-1 和 sn-2 位的 Palmitic acid 和一个 sn-3 位的 Linolelaidic acid。Palmitic acid 是一种广泛存在于动植物中的长链饱和脂肪酸,可诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。而 Linolelaidic acid 是一种 omega-6 反式脂肪酸 (TFA),作为一种能量来源和必需营养素,可添加于肠内、肠胃外和婴儿配方食品,并用于心脏病研究。
Others
HIT218847666
C6 NBD Galactosylceramide
T85989
170212-26-7
C6 NBD galactosylceramide 是一种带有荧光 nitrobenzoxadiazole (NBD) 标记的活性半乳糖神经酰胺 (galactosylceramide) 衍生物,用作中性 β-糖神经酰胺酶 (GCase) 的底物,研究半乳糖神经酰胺在细胞内的定位和代谢。
Others
HIT218832569
13-PAHSA
T84407
2169306-42-5
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are lipids influenced by dietary changes, playing a crucial role in insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid (for example, palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxy fatty acid with the same carbon chain length. 13-PAHSA, a derivative where palmitic acid is esterified to 13-hydroxy stearic acid, is notably prevalent in the adipose tissue of glucose-tolerant AG4OX mice, which exhibit enhanced glucose transport via the overexpression of the Glut4 glucose transporter. This observation, along with the metabolic benefits seen from other FAHFAs—including improved glucose tolerance, stimulated insulin secretion, and anti-inflammatory properties—suggests that 13-PAHSA may function as a bioactive lipid beneficial in managing metabolic syndrome and inflammation.
Others
HIT218832564
Harzianopyridone
TN7266
137813-88-8
Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.
Antifungal
Others
HIT218638095
γ-Linolenoyl monoethanolamide
T84459
150314-37-7
γ-Linolenoyl monoethanolamide,一种脂肪N-酰乙醇胺,属于内源性大麻素。
Cannabinoid Receptor
Others
HIT218638489
1-Myristoyl-2-Linoleoyl-3-Oleoyl-rac-glycerol
T85058
108961-58-6
1-Myristoyl-2-linoleoyl-3-oleoyl-rac-glycerol, a triacylglycerol, features myristic acid, linoleic acid, and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. This compound is prevalent in mature human milk, infant formula fats, and butterfat.
Endogenous Metabolite
Others
HIT218832869
C16 1-Deoxyceramide (m18:1/16:0)
T85052
1246298-56-5
C16 1-Deoxyceramide (m18:1/16:0) 是一种脂质分子,可用于生命科学相关研究,其 CAS 号为 1246298-56-5。
Endogenous Metabolite
Others
HIT218848352
JF526–Pepstatin A TFA
T86764
2410614-07-0
JF526–Pepstatin A TFA, a fluorescent dye, is utilized for lysosomal staining in live cells. It exhibits an excitation maximum at 530 nm and an emission maximum at 549 nm [1].
Others
HIT212725607
1,3-Dielaidoyl-2-Oleoyl Glycerol
T84992
946577-28-2
1,3-Dielaidoyl-2-oleoyl glycerol is a triacylglycerol consisting of elaidic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position.
Others
HIT214323340
FFN270 hydrochloride
T39878
2341841-05-0
FFN270 hydrochloride, a fluorescent tracer for norepinephrine and vesicular monoamine transporters, features dual resolved absorption/excitation peaks that vary with solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm). It serves as a ratiometric fluorescent pH-sensor, highlighting its utility in monitoring norepinephrine.
Adrenergic Receptor
Others
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