Others

Bilirubin conjugate is a stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives. In vivo, bilirubin circulates in the plasma and is taken up by hepatocytes and conjugated to one or two glucuronic acids in a reaction catalyzed by UDP glucuronidase to form bilirubin mono or diglucuronide. This water-soluble form is then excreted from the liver in bile in the feces or is converted to urobilinogen and excreted in the urine. In addition to aiding in the disposal of heme, bilirubin and its conjugated derivatives have been shown to exhibit anti-oxidant and antimutagenic effects and to play a role in gut barrier function.

Sardomozide dihydrochloride (CGP 48664 dihydrochloride) 是 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 的抑制剂 (IC50 = 5 nM)。

Amino-PEG3-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiophene-2-boronic acid neopentyl glycol ester 是一种化学合成模块，常用于 Suzuki–Miyaura 反应，作为硼酸酯底物用于构建碳–碳键，在合成化学研究中具有广泛应用价值。

FM1-43 是一种亲脂性很强的水溶性苯乙烯染料，可当作毛细胞机械换能器通道的渗透阻滞剂，可用来研究神经肽颗粒动力学和胞吐作用。

Methyltetrazine-PEG13-NHS ester is a polyethylene glycol (PEG)-derived linker, designed specifically for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Ulevostinag (MK-1454) is a STING agonist.

Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

Dihydromunduletone (DHM) 是一种粘附 G 蛋白偶联受体 (aGPCR）拮抗剂，可做一种化学探针，对具有相似拴系激动剂的 GPR56 和 GPR114/ADGRG5 有抑制作用。

TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.

Benzyl butyrate是一种酯类化合物，广泛应用于生物化学实验和药物合成研究。

(S)-(+)-2-Pentanol是一种手性醇，可用于生物化学实验和药物合成研究。

Dasatinib (Standard) 是一种可用于分析的标准物质，通常用作 Dasatinib 的研究和分析中参考的标准样品。Dasatinib (BMS-354825) 是一种酪氨酸激酶抑制剂，抑制 Src 和 Bcr-Abl (Ki=16/30 pM)，具有口服活性和 ATP 竞争性。Dasatinib 具有抗肿瘤活性，用于治疗白血病和淋巴瘤等。

Flavin adenine dinucleotide disodium salt (Standard) 是一种可用于分析的标准物质，通常用作 Flavin adenine dinucleotide disodium salt 的研究和分析中参考的标准样品。Flavin adenine dinucleotide disodium salt (FAD sodium salt) 是一种辅酶，作用是促进细胞氧化还原反应中黄素酶的电子转移。

Pazufloxacin (T-3761)是氟喹诺酮类广谱抗生素。

Dihydrodaidzin shows cytotoxic activities against human stomach carcinoma (Hs 740.T, Hs 756 T), breast adenocarcinoma (Hs 578 T, Hs 742.T), and prostate carcinoma (DU 145, LNCaP-FGC) cell lines.

LEO 134310 是一种选择性非甾体糖皮质激素受体 (GR) 激动剂，优化用于局部治疗。LEO 134310 在 GR 结合试验中显示出高亲和力(EC50为 14 nM)。LEO 134310 可用于皮肤病。

BPK-21 is an active acrylamide compound that effectively suppresses T cell activation by blocking the function of ERCC3, a helicase enzyme. BPK-21 specifically targets C342 within the ERCC3 helicase.

PCSK9 modulator-3 (Compound 13) 是PCSK9的有效调节剂，EC50值为 2.46 nM，在高脂血症研究中具有潜力。PCSK9 是已证实的降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。

AChE-IN-15 (Compound 3d) 是一种可逆的人乙酰胆碱酯酶 (huAChE) 和人丁酰胆碱酯酶 (huBChE) 抑制剂，对 huAChE 和 huBChE 的 IC50 值分别为 6.8 μM、16.1 μM，具有明显的抗氧化活性。AChE-IN-15 能够用于研究阿尔茨海默症。

MeCY5-NHS ester (potassium) is a reactive dye designed for labeling proteins and nucleic acids.

(S, R, S)-AHPC-C6-NH2 hydrochloride (also known as VH032-C6-NH2 hydrochloride) is a synthetic E3 ligase ligand-linker conjugate. It combines the VH032-based VHL ligand with a linker designed for AKT PROTAC degrader applications.

TCO-PEG8-TCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HP1142 is a highly effective and specific inhibitor targeting the FLT3 receptor tyrosine kinase, with a particular affinity for its mutant variant FLT3/ITD. It exhibits a benzoimidazole scaffold-based structure, making it a promising compound for investigating and studying the FLT3/ITD mutation in the context of leukemia research [1].

Syringaresinol diacetate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5083，CAS号为 1990-77-8。

GABAA receptor agonist

HO-PEG1-benzyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

GPR84antagonist 3 (compound 42)为一种高效GPR84(G 蛋白偶联受体 84)拮抗剂，具pIC50值为8.28，表现出对GTPγS的抑制作用，并拥有良好的药代动力学特性。

Hypaconine 是一种 C19-二萜生物碱，从乌头和飞燕草属中分离出来得到。 它表现出强烈的心脏活性。

m-PEG37-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

2,8-Dimethylquinoline是一种含有两个甲基的喹啉类化合物，广泛应用于生物化学实验和药物合成研究。

BNP (1-32), human 是一种脑利钠肽。

Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.

PSI-697 (P-Selectin Inhibitor) 是一种可口服的 P-选择素抑制剂，具有抗炎和抗血栓形成，可用于研究动脉粥样硬化等心血管疾病。

NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid utilized as an endogenous nitrosation indicator in gas chromatography-thermal energy analysis.

3-Isobutylaniline 是一种关键的合成中间体，可用于制备多种具有生物学和化学活性的化合物。凭借其多样且高效的反应活性，3-Isobutylaniline 能够支持功能化衍生物和复杂分子骨架的构建，从而推动生物医学与药物科学研究的发展，并为有机化学和药物化学的机理研究提供支持。