Others

Viral 2C protein inhibitor 1 (compound 6aw) 是广谱抗肠病毒剂，可抑制病毒 2C 蛋白。Viral 2C protein inhibitor 1 具有相对较低的细胞毒性和较高的选择性指数。Viral 2C protein inhibitor 1 可抑制 EV-D68、EV-A71 和 CVB3 等多种菌株，EC50值为 0.1~3.6 μM。

Anticanceragent 166 (compound 3)表现出对Caco-2细胞的显著抑制效果，其半数抑制浓度（IC50）为9.6 nM。

Abiraterone decanoate 是 Abiraterone 的前药，通过肌肉注射（IM）给药可实现控释和延长对酶 CYP17 的抑制作用。Abiraterone decanoate 的持续抑制能力在癌症研究中引起了广泛关注。

Febuxostat (Standard) 是一种可用于分析的标准物质，通常用作 Febuxostat 的研究和分析中参考的标准样品。Febuxostat (TEI 6720) 是一种选择性黄嘌呤氧化酶(XO)抑制剂，Ki=0.6 nM。

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

Angiotensin AT2 receptor agonist

BODIPY 493/503 carboxylic acid是一种绿色的BODIPY类荧光染料，具有亲脂性，常用于染色活细胞和固定细胞中的脂质、膜和其他中性脂类。

(Rac)-Neurodegenerative Disorder-Targeting Compound 1为一种针对神经退行性疾病的化合物，具有calpain抑制活性。

MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.

NH2-PEG7 is a para-aminomethylbenzyloxycarbonyl (PROTAC) linker compound consisting of a polyethylene glycol (PEG) chain. It finds application in the synthesis of the PROTAC PARP1 degrader called iRucaparib-AP6[1].

5'-O-Benzoyl-2'-O,4'-C-methyleneuridine is a Nucleoside Derivative - LNA related nucleoside; Protected nucleoside with NH2/OH open.

RIPK1-IN-15 (Compound 2.5) 是 RIPK1 的有效抑制剂，在神经退行性疾病、自身免疫性疾病和炎症性疾病研究中具有潜力。

Group III mGlu receptor agonist

VT-1598 是一种新型的、选择性的、口服居于活力的 fungal CYP51 抑制剂。VT-1598 对白色念珠菌表现出抗真菌效果。

t-Boc-Aminooxy-PEG8-alcohol is a PEGylated PROTAC linker suitable for synthesizing PROTACs[1].

m-PEG8-DSPE is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Nucleoside Derivatives - Xylo-nucleosides; Thio-nucleosides

S1QEL1.1（S1QEL）是线粒体呼吸复合物 I 位点 IQ 电子泄漏的抑制因子，可抑制 O2 诱导的 ROS 生成，并阻止 O2 诱导的 DA 关闭，可用于心血管疾病的研究。

Bis-(m-PEG4)-amidohexanoic acid is a polyethylene glycol (PEG)-based linker for proteolysis-targeting chimeras (PROTACs) synthesis[1].

NAGKi is an inhibitor of N-acetylmannosamine kinase (NAMK) and N-acetylglucosamine kinase (NAGK).

3'-F-3'-dG(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

Allolithocholic acid (Standard) 是一种可用于分析的标准物质，通常用作 Allolithocholic acid 的研究和分析中参考的标准样品。Allolithocholic acid （allo-LCA）存在于胆道闭锁婴儿尿液中，常以硫酸结合胆酸的形式排出。Allolithocholic acid 促进肠道和肝脏代谢。

R110 显示用于癌症研究的潜力，它是MIF2互变异构酶的竞争性抑制剂 (IC 50 = 15 μM) 。

FK-614 is a selective agonist of peroxisome proliferator-activated receptor gamma. FK-614 improves peripheral glucose utilization while decreases hepatic insulin extraction in alloxan-induced diabetic dogs.

Muvalaplin (LY3473329) 是一种具有口服活性的脂蛋白 (a) Lp (a) 抑制剂，可阻断 apo(a)-apo B100 相互作用来抑制 Lp(a) 的形成。

Azido-PEG16-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HS-PEG6-CH2CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-(N,N’-amine-PEG3)-Cy5 is a PEG-derived linker compound employed for the synthesis of PROTACs. It serves as a PEG-based PROTAC linker in the chemical structure[1].

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 4 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Muscarinic acetylcholine receptor agonist

Chloro-PEG5-chloride is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HCV-IN-7 is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake.

Ezurpimtrostat (compound 2-2) is used for the study of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases.

2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) 是一种有效的岩藻糖基转移酶 (FUT)抑制剂，在体外炎症模型中抑制唾液酸化和岩藻糖基化。

Muscarine chloride is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.

Indoramin, an orally active antihypertensive agent, exhibits selectivity for the α 1A -adrenoceptor [1].