Antibiotic

PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic linezolid .

A-39183A is an active component of the A-39183 antibiotic complex produced by aerobic fermentation of Streptomyces NRRL 12049. It has activity against penicillin-resistant S. aureus 3055 and S. faecalis X66 (MICs = 32 and 32 μg/ml, respectively) and a variety of Gram-positive and Gram-negative anaerobic bacteria (MICs = 16-128 μg/ml) in an agar dilution assay.

Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ofE. faecium-induced septicemia. It decreases the number of colony forming units (CFUs) in a mouse model of MRSA lung infection. 1.Martin, J., da S. Sousa, T., Crespo, G., et al.Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustrisMar. Drugs11(2)387-398(2013) 2.Mahajan, G., Thomas, B., Parab, R., et al.In vitro and in vivo activities of antibiotic PM181104Antimicrob. Agents Chemother.57(11)5315-5319(2013)

Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).

Rifametane is a new semi-synthetic rifamycin, an antibiotic produced naturally by the bacterium Amycolatopsis rifamycinica.

Sperabillin C is a potent antibacterial antibiotic in vivo isolated from Pseudomonas fluorescens YK-437.

AB023b is an antibiotic with antifungal properties.

AB023a is an antibiotic with antifungal properties.

3-O-Demethylfortimicin A is an antibiotic.

Astromicin Sulfate is an antibiotic with aminoglycoside structure. Astromicin Sulfate may produce depression of neuromuscular function.

Ritipenem属于penem类的抗微生物化合物。

Cilastatin ammonium salt 表现出对革兰氏阳性球菌的高效抗菌作用，其半衰期为3-4 h。

Anti-MRSA agent 19（Compound 1）是一种有效抗金黄色葡萄球菌的抗生素。该化合物对40种CDC分离出的细菌株显示出活性（中位 MIC=4 μg/mL），这些细菌株具有不同种类并携带多种耐药性因子，如万古霉素、氨基糖苷类/四环素及恶唑烷酮。

Ceftolozane TFA，一种头孢菌素类抗生素 (antibiotic)，主要用于治疗革兰氏阴性菌感染。此外，Ceftolozane TFA 也可用于开发更高效、更安全的新型抗生素 (antibiotic)。

Lambertellin 作为一种抗生素 (antibiotic)，在抑菌和抗真菌领域显示出不俗的效果。该化合物能够通过影响 MAPK 和 NF-κB 信号通路的激活，在 LPS 刺激的 RAW 264.7 巨噬细胞中展现出其抗炎特性。

Meropenem (SM 7338) sodium 是一种碳青霉烯类抗生素，具有广泛的抗微生物活性。该化合物对于敏感及耐药性强的淋病奈瑟氏球菌 (MIC 0.02-0.06 mg/mL)、流感嗜血杆菌 (MIC 0.03-0.12 mg/mL) 及杜克氏杆菌 (MIC 0.015-0.12 mg/mL) 均显示出显著的抑制效果。

PAMAM Dendrimer G0.0 amine 是一种孔形成通道拮抗剂，对炭疽毒素保护抗原 63 (PA63, IC50为 231 nM) 和肉毒梭菌 C2 毒素亚基 (C2IIa, IC50为 940 nM) 有效。在浓度为 10 和 20 µM 时，能够减少 C2 毒素引起的 HeLa 细胞死亡。此外，它作为镍的螯合剂，并在与聚砜膜结合的壳聚糖复合物中，能选择性地捕捉并储存二氧化碳 (CO2) 用于气体进料系统中。PAMAM Dendrimer G0.0 amine 已用于合成 PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) 和 PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5)。此化合物用于研究感染、癌症和药物递送系统。

CPW-86-363是一种新型羧基吡唑头孢菌素，属于广谱头孢菌素。该化合物通过胆汁排泄。

Actinobolin hemisulfate ((+)-Actinobolin hemisulfate) 是 Actinobolin 的半硫酸盐形式。这种抗生素通过靶向细菌和真核生物的核糖体来抑制蛋白质合成。它在抑制 Mycobacterium smegmatis、Escherichia coli 和兔网织红细胞裂解物 (RRL) 中表现出抑制活性，IC50分别为 19.2、27.9 和 288 μmol/L。

α-Apooxytetracycline 是 Oxytetracycline 的降解产物。Oxytetracycline 属于四环素类抗生素。

Dactylocyclines B is a novel tetracycline derivative produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp.

DNAC-1 is against Gram-positive and Gram-negative pathogens potentiator of β-lactam activity.

Leucinostatin K is a new peptide antibiotic from Paecilomyces lilacinus.

Antibiotic SF 2132 is a bioactive chemical.

Aldecalmycin is a new antimicrobial antibiotic isolated from Streptomyces.

Ceforanide lysine is an Anti-Infective.

Dactimicin is a novel pseudodisaccharide aminoglycoside. It has activities in vitro and in vivo antibacterial. Dactimicin was more resistant than astromicin to inactivation by aminoglycoside 3-acetyltransferase.

Altromycin C is a new pluramycin-like antibiotic.

Cefuzonam sodium is a second-generation cephalosporin antibiotic. It may be effective against Staphylococcus aureus against which third-generation cephalosporins are largely ineffective.

Chitotriose，一种可从蟹壳中提取的低聚壳聚糖，具有针对salmonella的抗菌效果。

N-Demethylvancomycin，一种源自Nocardia orientalis的糖肽类抗生素，对多种金黄色葡萄球菌和表皮葡萄球菌菌株显示出抗菌活性，常被应用于感染相关研究。

Phloroglucide 是一种从蕨类植物中分离的天然产物。

Kurchessine (Sarcodinine) 为从Holarrhena antidysenterica茎皮中提取的一种生物碱。

KT2 是一种阳离子两亲抗菌肽，能够彻底消灭 (E. coli) O157:H7 细胞。KT2 展现出强大的抗生物膜活性，可阻止 E. coli O157:H7 生物膜的形成。其能够有效结合细菌表面的 LPS，并与脂质体中的脂质发生相互作用，具有渗透性，可深入细菌细胞与 DNA 及其他细胞质膜结合。

N(5)-Hydroxy-L-arginine是一种抗生素，具有对革兰氏阳性菌和革兰氏阴性菌的活性。

Pyrrolomycin B 是一种吡咯类抗生素，具有抗革兰氏阳性菌、抗革兰氏阴性菌和抗个别真菌的活性。