Others

PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3(LOXL2/LOXL3)的双抑制剂，对几乎所有哺乳动物物种 LOXL2的 IC50均< 40 nM，对人类 LOXL3 的 IC50为63 nM。PXS-5153A monohydrochloride 可减少交联并改善纤维化。

Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM) and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e

Quinupristin is a streptogramin antibiotic. Streptogramins, a class of antibiotics, is effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, which are two of the most rapidly growing strains of mul

PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.

Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system. Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist.

L-ANAP hydrochloride is a polarity-sensitive and genetically encodable fluorescent unnatural amino acid.

KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor

Tyvelose is an unusual 3,6-dideoxyhexose terminal sugar and the immunodominant component of glycoprotein antigens in the parasitic helminth T. spiralis, which is responsible for trichinosis in humans. It is produced in high amounts by the infective larva and is immunodominant during the muscle stage of infection. Mice immunized with tyvelose-BSA produce IgG1 antibodies to tyvelose but are not resistant to infection by T. spiralis. Tyvelose-specific antibodies (2.5 mg/20 g) administered to rat pups leads to expulsion of first stage larvae from the intestine within one hour.

2-Iodoacetamide (Iodoacetamide) 是常用的烷基化剂之一，能够在蛋白质组学样品制备过程中，将半胱氨酸烷基化。

(L)-Sodium lactate (Sodium L-Lactate) 是由乳酸脱氢酶从丙酮酸中产生的。它在无氧糖酵解过程中或增殖活跃的细胞中产生。 它在人和动物的血液和肌肉液中少量存在。剧烈运动后，肌肉和血液中的乳酸浓度会增加。 它也存在于肝脏、肾脏、胸腺、人羊水以及其他器官和体液中。

NOTA-NHS ester 是一种与核素偶联药物 (RDC) 相关的分子，可用于荧光标记及放射性核素标记的应用。

AU-16235是AU-15330的非活性差向异构体，对癌细胞的存活和生长没有影响。

5-Azidopentanoic acid (5-Azidovaleric acid) 是一种适用于点击化学反应的有机酸。

FtsZ-IN-11 (compound B6)，一种FtsZ抑制剂，其对XooFtsZ的IC50为235 μM。该化合物可以与XooFtsZ结合，抑制其GTPase活性，从而引起细菌细胞的伸长，并可能导致其死亡。

Bensuldazic acid (compound 4f) 作为一种亲脂的 3,5-二取代四氢-2H-1,3,5-噻二嗪-2-硫酮 (THTT) 衍生物，能够用作前药模型。此化合物显示出抗真菌活性。

SNAP-fusion protein ligand-1 (Compound 1i) 是一种PROTAC的靶蛋白配体 (Ligand for Target Protein for PROTAC)，可用于合成PROTAC VHL-SNAP2-5C。

FCHFHS-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1].

(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1, which is an estrogen-related receptor alpha (ERRa) degrader. PROTAC ERRα Degrader-1 consists of an MDM2 ligand binding moiety, a linker and an ERRa binding moiety [1].

DiZPK Hydrochloride is a structural analog of pyrrolysine (Pyl), acting as a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.

TAMRA-PEG4-methyltetrazine is a polyethylene glycol (PEG)-based linker employed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

6-FAM azide (FAM azide, 6-isomer) 是一种荧光染料，作为含叠氮基团的点击化学试剂。其 Azide 基团能够与含 Alkyne 基团的分子进行铜催化的叠氮-炔环加成反应（CuAAc），也可以与带有 DBCO 或 BCN 基团的化合物发生环张力促进的炔-叠氮环加成反应 (SPAAC)。

Hexa-His TFA 是一种由6个组氨酸单位组成的六肽，通常作为融合蛋白的金属结合位点。

α-NAD (α-Nicotinamide Adenine Dinucleotide) 是肾素酶的底物，具有与 β-NAD 类似的功能，能够影响 NAD 依赖性酶的动力学，并且在线粒体氧化还原反应中作为重要的辅助因子发挥作用。

MAC-VC-PABC-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1].

Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041. INY-03-041

TAMRA-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DPP-8/9 probe-1 (compound 20) 是一种针对DPP8/9的荧光探针，其特点是含有硝基苯并恶二唑 (NBD) 标签，能在体外通过荧光显微镜高选择性地标记并可视化活跃的DPP8/9。该化合物对DPP8/9显示出较高的亲和力与选择性，与S9家族其他成员相比，其IC50值分别为210 nM和15 nM。

QTZ为腔肠素类似的生物发光剂，在活体成像中应用，其发射光具红移特性，且能确保较低的成像背景。

DND-189 is a low-pH fluorescent probe sensitive to both neutral and low pH ranges. It is useful for measuring the pH of acidic organelles [1] [2].

4-Di-16-ASP为膜染料，属亲脂性氨基苯乙烯基探针，发射光谱宽（适用绿色、橙色或红色滤光片检测）。适应于神经元膜追踪，扩散速度优于DiO。

Suc-Ala-Ala-Phe-AMC为一荧光胰凝乳蛋白酶底物，可遭肽链内切酶所水解。该化合物适用于顶体反应的体内测定及体外酶活性分析。

DTNP是一种具有血脑透过性的BchE激活的近红外 (NIR) 探针，可被BchE激活并抑制其酶活性，适用于阿尔茨海默病 (AD) 的研究。