Others

SBP-3264是一种常用于研究急性髓性白血病中 STK3和 STK4左右价值的化学探针。

CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively (WO2019207463A1, example A93).

Amino-PEG24-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Enduracidin B, a polypeptide antibiotic, is a prominent constituent of Enduracidin. This antibiotic is synthesized by Streptomyces fungicides.

(S)-Rasagiline mesylate is rasagiline S-isomer, and is an agent of anti-Parkinson.

Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].

Azido-PEG5-triethoxysilane serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Mifamurtide protects mice against herpes simplex virus type 2. It also is a macrophage activator.

N-(Aminooxy-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG)-based linker primarily utilized in PROTAC synthesis for the development of proteolysis-targeting chimeras (PROTACs)[1].

Benzoquinoquinoxaline（BQQ）是一种具有氨基烷基侧链的杂环化合物，含有苯并和喹啉环结构。BQQ是三螺旋特异性稳定化合物，通过优先结合到DNA三重结并插入碱基之间。BQQ与1,10-phenanthroline的复合物能够特异性地结合并在形成三重结构的位点上切割双链DNA。

PF 03709270 is an orally available ester prodrug form of sulopenem. It has broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.

8-Nitroguanine 是由活性氮物引起的 DNA 硝化损伤的产物，可能是恶性纤维组织细胞瘤进展的潜在生物标志物。

Antileishmanial agent-10 (Compound 7h) 是一种抗原虫 (antiprotozoal) 剂。

Benzyl-PEG5-NHBoc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-NH-PEG8-CH2CH2COOPFP ester is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].

Pulchinenoside K是一种发现于Anemone rivularis的三萜皂苷，对HSC-T6细胞具有抗增殖活性（IC50=18.21 µM）。

MK-447 is a nonsteroidal antiinflammatory agent.

TLR7 agonist12 (example 20) 是一种针对惰性淋巴系统恶性肿瘤具有广泛抗肿瘤活性的TLR7激动剂及嘌呤核苷类似物。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)来实现。

Anticancer agent 170 (compound 3a)，一种酮类衍生物，展现出对A549细胞株显著的抗癌效力，其半抑制浓度（IC50）为6.62 μM。

Aladorian (ARM036) is a benzothiazepine derivative and it has anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2].

Indoxyl sulfate (Standard) 是一种可用于分析的标准物质，通常用作 Indoxyl sulfate 的研究和分析中参考的标准样品。Indoxyl sulfate 是色氨酸的代谢产物，会对骨骼和中枢神经系统产生不良影响，且最常被指认为是导致肾病恶化和血管疾病的一个因素。

EFdA-TP, a highly potent nucleoside reverse transcriptase (RT) inhibitor, exerts its inhibitory effect on RT-catalyzed DNA synthesis through both immediate and delayed chain termination mechanisms, commonly referred to as ICT and DCT, respectively. Additionally, EFdA-TP demonstrates its efficacy in inhibiting HIV-1 RT through multiple pathways.

VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1].

10-Hydroxyscandine是一种天然产物，属于夹竹桃科山橙属，其产品编号为 TN2570，CAS号为 119188-47-5。10-Hydroxyscandine可用作对照参考。

MIND4-17为一种NRF2激活剂，通过共价修饰Keap1的C151残基发挥作用。该化合物能破坏Keap1-Nrf2之间的结合，进而促进Nrf2蛋白的稳定性及其向核内的迁移，显示出显著的抗氧化活性。

Minocromil is a new agent of Anti-asthmatic.

2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].

Antibacterial agent 101 表现出抗细菌和抗真菌作用(MIC=4-32 μg/mL)。

PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).

Maximin 5，源自Bombina maxima皮肤分泌，此抗菌肽对肿瘤细胞显示出显著的细胞毒性及杀精效果。

BnO-PEG1-CH2CO2tBu is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

mGAT3/4-IN-1 是 mGAT3/mGAT4 的有效抑制剂，他们的 pIC50 值分别为 5.31 和 5.24。在糖尿病神经病变小鼠中，mGAT3/4-IN-1 能够明显抑制触觉异常性疼痛。

5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.

AWL-II-38.3 是一种高效 EphA3 抑制剂，它对 EphA3 具有强效的激酶抑制活性，但对 Src 家族激酶或 b-raf 没有显著的细胞活性。

Thiol-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N,N'-Diphenylguanidine (NSC-3272) 是一种生化剂。