Others

N-Aminofluorescein 是一种对 Cu2+ 具有高度选择性和敏感性的荧光探针，可用于检测生物体系中的 Cu2+ (λex/em=495/516 nm)。

2-Amino-1,3-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based linker utilized for PROTAC synthesis[1].

Influenza virus-IN-3 (compound 9) 是一种选择性流感病毒的有效抑制剂，能够作用于 H5N1 (IC50: 0.88 μM)、H5N2 (IC50: 0.10 μM)、H5N6 (IC50: 5.5 μM)、H5N8 (IC50: 0.51 μM)。Influenza virus-IN-3 具有抗病毒和 NA (神经氨酸酶) 抑制作用，且细胞毒性低 (CC50>200 μM)。

Tubulin polymerization-IN-26 (compound 12h) is a chemical compound that inhibits the polymerization of microtubulin. It achieves this by binding to the colchicine binding site of microtubulin, with an IC50 value of 4.64 μM. Additionally, Tubulin polymerization-IN-26 has the ability to induce apoptosis and inhibit cell metastasis or migration. Due to these properties, it holds potential as a valuable compound for researching lung cancer [1].

GSK1482160 is a potent and selective P2X7 receptor allosteric modulator.

m-PEG4-phosphonic acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.

8-Keto-berberine is a non-naturally occurring 11, 12-oxygenated protoberberine. It is a derivative from naturally occurring 9, 10-oxygenated protoberberine.

PHOME是一种酶底物，可用于研究神经系统疾病和炎症。

Cephalonium (Cefalonium) 是第一代头孢菌素类抗生素。

Coumarin hydrazine是一种含有芳香肼基团的荧光团， 作为一种荧光化学探针，标记细胞内蛋白质和脂质结合的羰基；还可作为活细胞中的荧光传感器，用于检测氧化应激后产生的羰基化生物分子

Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.

Nucleoside Derivatives - 7-Deaza-purine nucleosides; 6-De-aminopurine nucleosides

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.

Asp-AMS is a strong competitive inhibitor of the mitochondrial enzyme and also an aspartyl-tRNA synthetase inhibitor.

5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA).

Blue FPG-A trisodium是一种针对P2X1受体和P2Y1受体具有选择性拮抗作用的化合物，IC50值分别为35.5 μM和2.6 μM。它是活性蓝2组成成分之一的结构异构体。

Pomolic acid 28-O-beta-D-glucopyranosyl ester is a natural product

Diacetolol is the major metabolite of acebutolol, a selective beta blockers used to treat hypertension, angina pectoris and arrhythmia.

1,2-Diphenoxyethane由两个苯氧基通过乙烷连接而成，广泛应用于生物化学实验和药物合成研究。

TCRS-417 (T417) 抑制哺乳动物细胞或细胞群中 PBX1-DNA 相互作用，可用于研究自身免疫性疾病和神经退行性疾病。

2"-O-beta-L-galactopyranosylorientin (2''-O-β-L-Galorientin) 提取自Trollius ledebouri 的花朵。它是多药耐药蛋白2 (MRP2) 的底物，能够被动扩散，并涉及转运蛋白介导的外排作用。

Antibacterial agent 98 (compound g37) 是口服有效的抗菌剂，可以抑制 Gyrase B 的 ATP 酶活性并削弱金黄色葡萄球菌 (S. aureus )的DNA 超螺旋。Antibacterial agent 98 不会诱导 MRSA (耐甲氧西林金黄色葡萄球菌 (S. aureus)) 的耐药性发展。

BChE-IN-15 是一种伪不可逆、共价BChE 抑制剂，对 hBChE 的IC50为 1.76 nM。

NSC243928 mesylate 可与人类淋巴细胞抗原 6 (LY6) 结合，是细胞生长抑制剂，具有抗癌活性，以 LY6K 依赖性方式诱导三阴性乳腺癌细胞的细胞死亡。

Nucleoside Derivatives - 2-Modified purine nucleosides; 6-Modified purine nucleosides

CBL 0100 free base是一种HIV-1转录抑制剂，在体外和离体模型中阻断HIV-1复制和再激活，靶向促进染色质转录（FACT）复合物,降低RNA Polymerase II和FACT在HIV-1启动子区域的占用，可以作为潜伏期促进剂（LRAs）用于cART疗法。

Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。

Lenalidomide-5-Br is a Lenalidomide derivative that functions as a ligand for cereblon (CRBN), thereby facilitating the recruitment of CRBN protein. It can be conjugated to the protein ligand through a linker to generate a PROTAC molecule.

4,4-Dimethyl-2-cyclohexen-1-one是一种不饱和环酮，广泛应用于生物化学实验和药物合成研究。

YG1702为ALDH18A1特异性抑制剂，具有良好效能。通过抑制ALDH18A1，YG1702能够有效抑制MYCN扩增的NB细胞生长，并降低MYCN表达水平。该化合物能高度亲和性地与ALDH18A1结合，可能进一步调节酶的活性。

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 是一款钌基化合物，既可作为量子点 (QDs) 荧光猝灭剂，也适用于捕获病毒抗原EV71的探针。此外，该化合物还用于作为灵敏的电致化学发光 (ECL) 试剂，用于基质金属蛋白酶 (MMP)[2] 的检测。

Varenicline Hydrochloride (CP 526555) 是一种口服活性的α4β2 烟碱型乙酰胆碱受体（α4β2 nAChR, IC50 = 250 nM）部分激动剂，该受体被认为是尼古丁依赖的主要介质，其药理作用在调控与尼古丁暴露相关的成瘾行为中具有关键意义。Varenicline Hydrochloride (CP 526555) 阻断尼古丁对烟碱型乙酰胆碱受体的直接激动作用，同时以更温和和可控的方式刺激这些受体，使其成为广泛用于戒烟研究的重要化合物。

Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. [1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4(2):88-94.

DOTATATE acetate 是一种 DOTA 结合肽，是生长抑素类似物，也是一种新型 PET 示踪剂，参与评估高分化神经内分泌肿瘤 （NET） 的功能性成像。

A1AR antagonist 5 (化合物 20) 是A1 腺苷受体(A1AR)的有效选择性拮抗剂，其pKi 值为 6.11，pIC50值为 5.83。