Others

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a Nucleoside Phosphoramidite.

Grazoprevir is a drug approved for the treatment of hepatitis C. Grazoprevir is a second-generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets.

PKM2-IN-3 is a potent PKM2 kinase inhibitor, displaying an IC 50 value of 4.1 μM. The compound effectively suppresses PKM2-mediated glycolysis and NLRP3 activation, thereby exerting an anti-neuroinflammatory effect.

20(R)-Notoginsenoside R2是一种天然的皂苷，对H9C2细胞具有较弱的抑制活性。

Mogroside III-A2 exhibits inhibitory effects with IC50 values of 346-400 mol ratio/32 pmol TPA. and shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor.

N-Phenylnaphthalen-1-amine可用作疏水性的荧光探针，用于检测表面活性剂的临界胶束浓度，有机锂和有机镁试剂浓度，以及细胞中膜脂质的相变。是一种用于气味结合蛋白 (OBP) 的荧光探针，具备 1.67 μM 的解离常数，激发波长为 337 nM，发射波长为 407 nM。

TLR7/8 agonist 9 (Compound 25a) 是一种能够增强PD-1/PD-L1阻断疗法抗肿瘤效果的化合物，主要用于癌症免疫疗法研究。它对hTLR7和hTLR8的EC50分别为40 nM和23 nM，显示出其对这两种受体的高亲和力以及潜在的抗肿瘤活性。

(±)16,17-EDT，一种经由细胞色素P450 (CYP) 途径形成的腺苷酸代谢物和氧脂肪酸，能够诱导分离的猪小动脉舒张（EC50 = 11 pM）。此外，(±)16,17-EDT 亦能促进以TP受体激动剂U-46619 预收缩的分离牛冠状动脉的松弛。

NH2-PEG2-methyl acetate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.

PFM39 是一种选择性 MRE11 核酸外切酶抑制剂，是 Mirin 类似物，可延长有丝分裂。PFM39 抑制 HR，可缓解由 EXO1/BLM 耗竭引起的修复缺陷。

Tubulin polymerization-IN-39，一种以IC50为4.9μM抑制微管蛋白聚合，通过占据秋水仙碱结合位点来实现其作用。此外，Tubulin polymerization-IN-39能有效抑制癌细胞增殖。

Antibacterial agent 123 (compound 111) 是一种有效的膜破坏剂，可以对抗耐药的革兰氏阳性菌。

(Arg)9 TFA (Peptide R9 TFA) 是一种可渗透细胞的多肽，在谷氨酸模型实验模型中保护神经(IC50:0.78 μM)。

Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1].

H1PVAT 是一种强效的、选择性的脊髓灰质炎病毒 (PV) 血清型 PV-1，PV-2，PV-3 抑制剂，对病毒的早期复制具有抑制作用。H1PVAT 能够直接作用于病毒衣壳，保护 PV 免受热灭活。

11-Hydroxy-sugiol is a natural product

A-410099.1, also known as amine-Boc, serves as a functionalized IAP ligand instrumental in the synthesis of PROTACs, including those targeting BTK (specifically PROTACs 4 and 5).

Azido-PEG12-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

EAPB 02303 是一种微管破坏剂和抑制剂。EAPB 02303 诱导有丝分裂停止和纺锤体组装损伤。因此，EAPB 02303 诱导细胞凋亡 (apoptosis) 并表现出抗肿瘤活性。EAPB 02303 在较低浓度下也表现出与紫杉醇 的强协同作用。

5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone 是来自印楝树皮的黄酮类化合物。

Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner.

Physalin C, a natural product derived from Physalis alkekengi, is classified as a secosteriod [seco-16,17]. It displays a yellow powder form and has a molecular formula of C28H36O10. This compound is notable for its multiple bioactivities, including anticancer, antifungal, and antiviral effects.

Lactic acid Lithium是锂盐与乳酸的化合物，可用于生命科学领域的相关研究。

4-Bromomethyl-6,7-dimethoxycoumarin 作为羧酸在色谱检测中的荧光标记物使用。

Yonkenafil (Tunodafil) 是一种新型PDE5抑制剂，对脑梗塞、神经功能缺损、水肿及梗塞区域神经元损伤具有显著降低效果。通过调节神经发生，Yonkenafil 可改善认知功能，展现出在阿尔茨海默病研究中的潜在价值。

Egis-11150 是一种抗神经病化合物，具有促认知功效。

Filgotinib (maleate) 是选择性的、口服具有活力的 JAK1 抑制剂，可有效抑制 JAK1 (IC50: 10 nM)，JAK2 (IC50: 28 nM)，JAK3 (IC50: 810 nM) 和 TYK2 (IC50: 116 nM) 的活性。Filgotinib (maleate) 能够用于研究类风湿性关节炎（RA）和克罗恩病。

(1R,2R)-2-PCCA hydrochloride 是一种具有有效性、选择性和可穿过血脑屏障的 GPR88 受体激动剂，在 WT 小鼠纹状体膜中 EC50 值为1140 n。(1R,2R)-2-PCCA hydrochloride 可用于研究中枢神经系统。

Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.

GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).

m-PEG16-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

S3969 is a bioactive chemical.

4-Amino-3-iodopyridine 是一种用途广泛的合成构建单元，在药物研发、有机合成及材料科学领域中的重要性日益凸显。其独特的结构特征使 4-Amino-3-iodopyridine 成为制备多种具有生物活性的分子的关键中间体，广泛应用于药物发现和农业化学研究。当前研究持续评估其反应特性，以实现结构多样化类似物的构建，从而服务于功能材料和生物活性分子骨架的开发。

DHFR-IN-2 (化合物 4e) 是一种有效且非竞争性的MtDHFR 抑制剂，其IC50值为 7 μM。来自结核分枝杆菌 (MtDHFR) 的二氢叶酸还原酶具有很高的未开发潜力，可以成为抗结核病 (TB) 新药的靶标，因为它对病原体存活很重要。DHFR-IN-2可用于结核病(TB)研究。

CASK-IN-1 是一种高效、选择性的 CASK 抑制剂，Kd 值为 0.022 μM.