VDAC

VBIT-12 是一种有效的 VDAC1 抑制剂。

NSC 15364 (1,3-Bis(4-aminophenyl)urea) 是一种 VDAC1寡聚化和细胞凋亡抑制剂。

AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 protects against mitochondrial dysfunction[1]. AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis.

VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).

DIDS sodium salt (MDL101114ZA) 是有效的ABCA1和VDAC1双抑制剂。

VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂 (Kd=17 μM)。VBIT-4 可以预防线粒体功能障碍和细胞凋亡，并恢复细胞能量和代谢。VBIT-4 可用于治疗神经退行性疾病和心血管疾病。

WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).

Erastin 是一种作用于线粒体 VDAC 的铁死亡激活剂，具有 ROS 和铁依赖性。Erastin 具有抗肿瘤活性，选择性作用于 RAS 致癌突变的肿瘤细胞。

DIDS, an anion exchange inhibitor, acts by blocking reversibly and later irreversibly, exchangers such as chloride-bicarbonate exchanger. It is also a RAD51 inhibitor.

Tuvatexib 是一种小分子VDAC/HK2双调节剂。

SW016789 是一种针对VDAC1的高效分泌诱导剂。它直接促进β细胞的胰岛素分泌和钙离子内流，同时引发瞬时内质网应激（ER 应激），但不引起β细胞死亡。SW016789 诱导的反应可逆且不引发凋亡。该化合物可用于研究2型糖尿病（T2DM）中的β细胞功能障碍。