Antibacterial

Dactylocyclines are novel tetracycline derivatives produced by Dactylosporangium SP. The fermentation of Dactylosporangium sp. (ATCC 53693) produced a mixture of tetracycline derivatives, from which several related tetracycline glycosides, known as rings,

Carbendazim mixture with flusilazole is a bioactive chemical.

Guamecycline is a biochemical.

Carbavance, a mixture of Meropenham and Vaborbactam, is intended for adults with complex urinary tract infections (cUTI), including pyelonephritis, a kidney infection caused by certain bacteria.

Arizonin A1 is a biochemical.

Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that was initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml. Aspochalasin D is more cytotoxic, via apoptosis, to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium (IC50s = 0.49 and 1.9 μg/ml, respectively).

L 693989 is a pneumocandin.

1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66948，CAS号为 112811-72-0。

Brobactam Sodium Salt is a β-lactamase inhibitor.

Octenidine saccharin is a Dental Plaque Inhibitor

5'-Hydroxy-staurosporine is an AMPK inhibitor with selective toxicity toward human colon tumor cells.

Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/ml) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml.

Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).

Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus,B. subtilis,M. luteus,E. coli, andK. pneumoniae(MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively). Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III infection (ED50= 399.8 mg/kg).2

Streptothricin E is a biochemical.

Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol. It inhibits rat liver mitochondrial and E. coli protein synthesis by 90.6 and 98.8%, respectively, when used at a concentration of 93 μM, and inhibits DNA synthesis in human lymphoblastoid cells by 83% at 1 mM. Bromamphenicol can also bind to the major adhesin subunit DraE from E. coli.

SCH 725674 is an antifungal macrolide originally isolated from Aspergillus. It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively).

Tenonitrozole is a biochemical.

Drimentine A is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast and has anthelmintic properties.

N-Demethylvancomycin is a glycopeptide antibiotic that has been found inNocardia orientalis.1It is active against several strains ofS. aureusandS. epidermidisin vitroandin vivo.2Formulations containing N-demethylvancomycin have been used in the treatment of bacterial infections. 1.Boeck, L.D., Mertz, F.P., Wolter, R.K., et al.N-demethylvancomycin, a novel antibiotic produced by a strain of Nocardia orientalis. Taxonomy and fermentationJ. Antibiot. (Tokyo)37(5)446-453(1984) 2.Hunt, A.H., Marconi, G.G., Elzey, T.K., et al.A51568A: N-demethylvancomycinJ. Antibiot. (Tokyo)37(8)917-919(1984)

IT-143A is a bacterial metabolite originally isolated fromStreptomycessp. IT-143.1It is active against the bacteriumM. luteus(MIC = 6.25 μg/ml) and the fungiA. fumigatusandT. rubrumin vitro(MICs = 12.5-25 μg/ml). 1.Urakawa, A., Sasaki, T., Yoshida, K., et al.IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces SpJ. Antibiot. (Tokyo)49(10)1052-1055(1996)

Hodgkinsine B is an alkaloid and isomer of hodgkinsine that has analgesic activity.1It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg. 1.Kodanko, J.J., Hiebert, S., Peterson, E.A., et al.Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activityJ. Org. Chem.72(21)7909-7914(2007)

Protegrin-1是一种抗菌肽，具备显著的抗菌活性。

Zarzissine exhibits cytotoxicity against three human and murine tumor cell lines.

Aralia-saponin I 是从 Aralia elata 中提取的皂苷，具有与气溶素高结合亲和力，可结合气溶素的重要功能氨基酸。Aralia-saponin I 可用于研究嗜水气单胞菌感染。

Mecambrine (Fugapavine) 为一种从Papaver triniifolium Boiss中提取的生物碱。

Phytantriol 是一种脂肪醇，含有 Phytantriol 的 cubosomes 对 LPS 缺乏和多粘菌素耐药的鲍曼不动杆菌菌株具有杀菌作用。

Microcystin-LW为一种具有细胞毒性的细菌代谢物，且是Microcystin-LR的类似物。

GMPRGA, 源自噬菌体Spbeta，能够识别细菌胞质中的spAimR并促进溶原形成。

Mazethramycin B是一种抗肿瘤抗生素，源自S. thioluteus。它对九种细菌（例如S. aureus, B. subtilis, 和K. pneumoniae）的最低抑制浓度分别为3.12, 1.56, 和3.12 mg/ml，并对真菌C. pseudotropicalis的最低抑制浓度为6.25 mg/ml。在L1210小鼠白血病模型中，Mazethramycin B以31.3 mg/kg每天的剂量增加存活率。

(RFR)4XB 是一种能够穿透阳离子膜的肽类化合物。它能有效地通过革兰氏阴性细菌的外膜，运输其所携带的货物 (反义寡聚体)。

Mukonidine是一种天然存在的咔唑生物碱。

Trimethylsilyl-L-(+)-rhamnose是一种改性天然糖鼠李糖的化合物，用于研究其在细菌细胞壁中的活性。此化合物可用于调查细菌细胞壁的组成和生物学功能，有助于科学家深入理解细菌的生长和抗性机制。

α-Mycolic acid (C80) 是一种分枝杆菌细胞壁中的结构性脂质，可从 Mycobacterium tuberculosis Canetti 中提取。α-Mycolic acid (C80) 在显著调节膜通透性和稳定性方面具有重要作用，对研究结核分枝杆菌感染有潜在价值。

G(IIKK)3I-NH2 是一种有效的抗菌肽，对革兰氏阴性和革兰氏阳性细菌均表现出强大的抗菌活性。其对原代细胞和小鼠的毒性较低，并且不易引起细菌耐药性。G(IIKK)3I-NH2 可用于开发抗感染药物的研究。

7-Demethylpiericidin A1 是一种具备抗真菌和革兰氏阴性细菌活性的抗生素。