Antibiotic

Lydicamycin是从一种被鉴定为溶性链霉菌的放线菌菌株的发酵液中分离出的新型抗生素，Lydicamycin对革兰氏阳性菌和某种酵母菌有活性，但对革兰氏阴性菌无活性。[2]

Marbofloxacin hydrochloride，一种第三代具口服活性的氟喹诺酮类抗菌剂，展现广谱杀菌效能及优良疗效。适用于探究由革兰氏阳性与革兰氏阴性细菌及支原体所引发的感染。

Roemerine ((-)-Roemerine) 是一种来自塞内加尔番荔枝的卟啉生物碱，具有抗真菌和抗癌活性，通过抑制 Bmr 来防止小檗碱外排。Roemerine 以浓度依赖性方式增加细胞膜通透性，可用于研究真菌感染和前列腺癌。

Kanamycin sulfate (Kanamycin monosulfate) 属于氨基糖苷类抗生素，通过与细菌 70S 核糖体亚基结合来干扰蛋白质合成。Kanamycin sulfate 具有抗菌活性，对革兰氏阳性菌和阴性菌及支原体都有抑制作用。

Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.

Antimalarial agent 17是一种有效的抗疟剂和除草剂，也是一种photosystem II抑制剂，具有出苗后除草活性。

Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771)，作为一种宽谱抗葡萄球菌药物，对甲氧西林敏感金黄色葡萄球菌(MSSA)及对甲氧西林耐药金黄色葡萄球菌(MRSA)显示出显著的抗菌活性，并能有效减少THP-1单核细胞对MRSA和MSSA菌株的吞噬。

Cyclo(Phe-Pro) (A-64863) 是创伤弧菌的群体感应分子，能够与 RIG-I 的特异性相互作用，阻碍 RIG-I 的多泛素化，并抑制 IRF-3 的激活和 I 型干扰素的产生。它提高 HCV 和流感病毒的易感性。

Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

PGLa is a cationic antimicrobial peptide (AMP) originally isolated from frog. It has been shown to have antibacterial,antifungal,and antiviral,activities.

Posizolid(AZD-5847,AZD-2563) is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections.

Acetomycin is a γ-lactone microbial metabolite originally isolated from S. ramulosus that has anticancer activity. It inhibits proliferation of HCT-8 human colon and L1210 mouse leukemia cancer cells.

Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。

Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物，具有免疫抑制特性。它也是一种大环聚酮类抗生素，具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥，并具有用于各种皮肤病研究的潜力。

Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).

Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively).

NSC 31150 是一种潜在的 PPAR 激动剂，具有抗菌、抗糖尿病和抗氧化活性，可用于研究癌症和细菌感染。

Cloxiquine (Dermofongin) 具有抗菌，抗真菌和抗阿米巴虫的作用。它还可通过激活 PPARγ抑制黑素瘤细胞的生长和转移。它可研究结核病和皮肤病。

Ceftibuten is a third-generation cephalosporin antibiotic.

Delafloxacin (WQ-3034) 是一种广谱氟喹诺酮类抗生素，抑制耐药性的金黄色葡萄球菌，肺炎链球菌和肺炎克雷伯菌。

Eravacycline (TP-434) 是一种有效的广谱抗菌剂。

Artemether (CGP 56696) 是一种用于治疗急性单纯性疟疾的抗疟药。

Mafenide acetate, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.

PXYD4 是一种核糖体蛋白 S1 (RpsA) 拮抗剂，能够作用于 RpsA-CTD (Kd: 3.24 μM) 和 RpsA-CTD Δ438A (Kd: 1.64 μM)。其中 RpsA 在结核分枝杆菌 (Mtb) 的转译过程中具有着重要作用。

Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV).

Feudomycin A(封建霉素 A)是一种由突变链霉菌产生的蒽环类抗生素，在特定微生物作用下可以转化为adriamycin，具有潜在的抗肿瘤活性。

Methacycline hydrochloride (Rondomycin) 是四环素抗生素，可抑制细菌蛋白质的合成。它是上皮-间质转化 (EMT) 抑制剂。它在体外可阻断 EMT，体内抑制纤维发生，不会直接影响 TGF-β1 Smad 信号传导。它是抗菌剂，有潜力研究肺纤维化。

Niclosamide olamine (Niclosamide Ethanolamine salt) 是一种驱虫剂，可破坏寄生虫和动物模型中的线粒体代谢。它可逆地抑制雷帕霉素复合物的哺乳动物靶标，从而抑制STAT3(IC50为 0.25 μM) 并刺激自噬反应。

SPR741, formerly NAB741 (12), is a cationic peptide derived from polymyxin B and is one such potentiator molecule that is under development for the treatment of serious Gram-negative bacterial infections.

CP 67015 has an inhibitory effect on the function of topoisomerase, and is a direct mutagen in mammalian cells, which has effects on gene and chromosome levels.

Tetramycin B (4-Hydroxytetramycin A)为一种从吸水链霉菌（Streptomyces hygrospinosus var. Beijingensis）分离出的多烯大环内酯类抗生素，拥有较高的抗真菌活性，也可用于农业领域，对多种植物病原真菌表现出优异的抑制活性。相较于Tetramycin A，四霉素 B在抗真菌方面的效能更为显著，C-4位的羟基在增强生物活性方面发挥了关键作用。

BMAP-28为一种抗生肽兼具线粒体透性转换孔(inducing agent)功能，能够触发线粒体的透性转换孔(opening)，进而诱导细胞凋亡。该化合物在微生物感染及癌症研究领域具有潜在应用价值。

Butenafine hydrochloride (KP363 Hydrochloride) 通过抑制鲨烯环氧酶阻断甾醇的合成，具有抗真菌活性。

D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。

Imipenem (MK0787) 是一种噻吩霉素衍生物，属于抗生素类，具有抗菌活性，对革兰氏阳性和革兰氏阴性菌具有部分的抑制作用。Imipenem 可用于研究碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。