Others

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Esoxybutynin Chloride is (S)-enantiomer of oxybutynin. Esoxybutynin Chloride exerts antimuscarinic properties. Racemic oxybutynin is used clinically to treat urinary incontinence. Sepracor was developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence.

Caramiphen hydrochloride is the salt form of Caramiphne (free base), which is an antimuscarinic and anticholinergic agent. It acts as an antagonist of NMDA receptor.

MDL-74156 is an active metabolite of dolasetron and a 5-hydroxy-tryptamine3 (5-HT3) antagonist.

Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.

C1A is an inhibitor of HDAC6 which modulates downstream autophagy substrates and leads to growth inhibition of a diverse set of cancer cell lines.

Gepotidacin hydrochloride, also known as GSK-2140944 hydrochloride, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin hydrochloride is a novel antibacterial drug candidate. Gepotidacin hydrochloride Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin hydrochloride is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, Gepotidacin hydrochloride inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 μM). In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259

D-Pyrohomoglutamic acid is a building block. It has been used in the synthesis of immunoproteasome low molecular mass polypeptide 2 (LMP2) subunit inhibitors and is a component of substance P peptide analogs.

2-Nitrophenyl a-D-glucopyranoside 是一种 β-葡萄糖苷酶的底物。

Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, angiogenesis, and inflammation, interacting with MEK1, suppressing retinal CD31, pERK, VCAM-1, and VEGF-A165 expression.

AZD 1775 Linker Conjugate 1 TFA 是一种参与泛素酶靶向嵌合体实验的化合物。

MAC-5576 a SARS-CoV-2 Protease inhibitor (IC50 = 81 nM).

Indacaterol xinafoate is an ultra-long-acting beta-adrenoceptor agonist.

MOTS-c为源于线粒体的多肽（MDP），它通过激活AMPK途径并抑制MAP激酶-c-fos信号通路，具有抗损伤和抗炎效应。

Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.

O-allylvanillin为o-烯丙基查尔酮衍生物，呈现抗癌活性。该化合物对THP-1、HL60、Hep-G2、MCF-7细胞系生长抑制作用显著，其IC50值依次为74.76 μM、63.52 μM、90.99 μM、90.11 μM。

Sucrose octasulfate为硫糖铝组分，能直接刺激胃粘膜D细胞以促进生长抑素样免疫反应(SLI)的释放，进而发挥内源性胃生长抑素的溃疡愈合功能，适用于抗胃溃疡研究。

Nocarimidazole A，一种来源于海洋放线菌Nocardiopsis的白色无定形固体生物碱，具紫外线活性。

Embramine (hydrochloride) 为具有抗组胺及抗胆碱能特性的单乙醇胺类化合物。

Human enteropeptidase-IN-3是一种肽类酶抑制剂，主要作用于肠肽酶，具有长效抑制功能。该化合物广泛应用于研究肠道消化相关疾病。

Indoramin (hydrochloride) is a novel antihypertensive agent that exhibits selectivity for the α1A-adrenergic receptor.

AP-C3为cGMP依赖性蛋白激酶II (cGKII) 的有效抑制剂，其pIC50值为6.3。该化合物仅对cGKII依赖性阴离子分泌表现出微弱的抑制作用。

ATUX-1215是一种蛋白磷酸酶 2A (PP2A)的激活剂，能够在BLM治疗的动物模型中降低ERK、p38、JNK和Akt的磷酸化及IL-12p70、GM-CSF与IL1α的分泌，从而有助于减缓肺纤维化的发展。

AP-C1是一种针对cGMP依赖性蛋白激酶II (cGKII) 的有效抑制剂，具有pIC50值为6.5。此化合物对cGKII所介导的阴离子分泌仅表现出微弱的抑制作用。

Biotin-hexanamide-(L-Thyroxine)为生物素化L-Thyroxine化合物。该化合物中的L-Thyroxine（即Levothyroxine；T4）作为一种合成甲状腺激素，广泛用于甲状腺功能减退症的研究中。

(±)9(10)-DiHOME, the diol derivative of (±)9(10)-EpOME—a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin—is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.

PDHK-IN-7（compound 32）作为丙酮酸脱氢酶激酶抑制剂，展示了17 nM的IC50值。此化合物可在大鼠肝脏中激活PDH，且对Zucker肥胖大鼠显现出降糖效果。

VU 0546110 是一种针对精子特异性钾通道 SLO3 的选择性抑制剂（IC50= 64 μM），相较于 SLO1 显示出 40 倍的选择性。它能完全阻断异源性 SLO3 电流和内源性 K+ 电流。VU 0546110 抑制精子超极化并阻止其超活跃移动。

PGF1β, a biochemical compound, functions as a pivotal mediator in inflammatory processes and plays an integral role in uterine contractions. It exhibits significant regulatory effects on platelet aggregation and vasodilation, demonstrating its critical importance in cardiovascular health. Additionally, PGF1β contributes to the regulation of kidney function and electrolyte balance, illustrating its widespread impact across various physiological systems.

6-Bnz-5'-AMP，一种adenosine-5'-O-monophosphate的亲脂类似物，也可能是N6-Benzoyl-cAMP的代谢产物。在烟草和大豆的组织培养中，此化合物显示出细胞分裂素的活性效应。

Hydroxy-PP是一种有效的CBR1抑制剂，IC50值为0.78 μM，同时有效抑制细胞质酪氨酸激酶Fyn，IC50值为5 nM。

DJ-1-IN-1 (compound 797780-71-3) 作为一种有效的DJ-1抑制剂，在ACHN细胞中展示出了明显的抗增殖特性，其IC50达到了12.18 μM。此外，该化合物还能够抑制Wnt信号通路，因而在癌症研究领域具有应用潜力。

Compound 25 (β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate)) 显示出显著的肿瘤细胞生长抑制效果。

CHI3L1-IN-1 (Compound 30)，作为CHI3L1(YKL-40)的抑制剂，具有 50 nM 的IC50值。此外，该化合物还可抑制hERG通道，其IC50为 2.3 μM。