Others

(R)-FTY-720 Vinylphosphonate is a sphingosine 1-phosphate type 1 (S1P1) receptor agonist and lacks anti-apoptotic activity.

Acetoacetyl coenzyme A sodium 是重要内源性代谢物，在pH 7.5时其Km值达1.10 mM，主要用于磷酸转丁基酶 (PTB) 与poly-3-hydroxybutyrate (PHB) 的合成。

VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH₄ receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction.

Trityl olmesartan medoxomil impurity II为Trityl olmesartan medoxomil的杂质，后者是Olmesartan medoxomil的中间体。

Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Tacrolimus anhydrous 8-epimer is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

LysoFos Glycerol 12 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0073，CAS号为 1423237-43-7。

Estrogen receptor antagonist4 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist4 具有研究癌症疾病的潜力。

GT-2394 is a histamine H3 receptor agonist.

SC-50605 is a second-generation LTB4 receptor antagonist.

AG-012917 is a broad spectrum cyclin-​dependent kinase inhibitors with potential anticancer activity.

BTZO-15 is a novel ARE activator, ameliorating DSS- and TNBS-induced colitis in rats.

SAR296968 is a novel selective NCX inhibitor, improving cardiac function and restoring sympathovagal balance in heart failure.

Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Colterol (free base) is a short-acting β2-adrenoreceptor agonist. Bitolterol, a prodrug for colterol, is used in the management of bronchospasm in asthma and chronic obstructive pulmonary disease.

Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over-expressed in cancers such as hepatocellular carcinoma (HCC), colorectal and ovarian cancers.

Ipenoxazone HCl is a glutamate receptor antagonist potentially for the treatment of Alzheimer's disease.

NZ-107 is an LTB4, LTC4 and LTD4 antagonist.

Cabergoline diphosphate is a dopamine D2 receptor agonist used for prolactinoma treatment. Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.

ZK-261557 is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.

MV061194 is a potent and selective cathepsin K (Cat K) inhibitor.

NC1 is a novel highly active allosteric inhibitor of protein tyrosine phosphatase, non-receptor type 22 (PTPN22) which is a lymphoid-specific tyrosine phosphatase (LYP).

NTZ-24 is a novel potent STAT3 inhibitor.

Cephradine sodium is the salt form of Cephradine (free base), a semi-synthetic cephalosporin antibiotic. Cefradin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cefradin may interfere with autolysin inhibitors.

Sevasemten为骨骼肌肌球蛋白(Myosin)的变构抑制剂，具有选择性抑制作用，其IC50值对骨骼肌球蛋白 ≤ 10 μM，而对心脏肌球蛋白则 >100 μM。

FAUC-179 is a selective dopamine D4 receptor partial agonist.

Cytidine 5′-diphosphoethanolamine 是磷脂酰乙醇胺合成的中间体，也是乙酰胆碱合成的刺激剂。

Amdakefalin is a μ and δ opioid receptors agonist that acts as an analgesic.

Picumeterol fumarate is a potent and selective beta2-adrenoceptor agonist that acts as a bronchodilator.

AY 31390 is a phosphodiesterase (PDE) inhibitor with antithrombotic activity.

KS99 is a dual inhibitor of BTK and tubulin polymerization.

Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism between Ki23057 and chemotherapeutic agents in drug-resistant cell lines. (source: Cancer Lett. 2011 Aug 1;307(1):47-52).

Ormosinine is an inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Hexbutinol methiodide is an inhibitor of muscarinic receptors.

ZL0516 is a is a chromone derivatives used as orally bioavailable BRD4-selective inhibitor. This BRD4 BD1 inhibitor has demonstrated impressive in vivo efficacy and overall promising pharmacokinetic properties, indicating its therapeutic potential for the treatment of inflammatory diseases.

5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) 为修饰核苷三磷酸，用以替代未修饰 mRNA，以增强翻译性能与稳定性，显著降低人类及其他哺乳动物细胞的先天免疫反应。