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Advanced Glycation End Products
CYP19A1
Decarboxylase
DprE1
Fer/FerT kinase
Platelet aggregation
Progesterone Receptor
Others
信号通路
其他
Others
Others
Targetmol为生命科学及医药领域的科研人员提供其他未细分细胞信号通路相关产品,包括抑制剂、激动剂、调节剂、降解剂等。
HIT212688402
R-96544
T84897
167144-80-1
R-96544 是一种具有口服活性的 5-HT2A 受体拮抗剂,可抑制体外血小板聚集。
5-HT Receptor
Others
HIT212730827
5β,6β-epoxycholestanol
TCL-00012
4025-59-6
5β,6β-epoxycholestanol 是由胆固醇在 5,6 双键处进行自由基或非自由基氧化后生成的氧化代谢物。在 U937 巨噬细胞样分化细胞中,该化合物可引发乳酸脱氢酶 (LDH) 的释放和诱导细胞凋亡。5β,6β-epoxycholestanol 已在人体脂肪条纹及晚期动脉粥样硬化病变中发现,但在正常主动脉组织中不存在。
Others
HIT212039042
Oleandomycin
T16382
3922-90-5
Oleandomycin is similar to Erythromycin has antimicrobial activity. Oleandomycin is a macrolide antibiotic structurally closely related to Erythromycin.
Antibacterial
Antibiotic
Others
HIT218832834
3β,5α,6β-Trihydroxycholanic Acid
T84988
16030-92-5
3β,5α,6β-Trihydroxycholanic acid, a metabolite derived from 5α,6β-dihydroxycholestanol, exhibits elevated levels in dried blood spots of patients diagnosed with Niemann-Pick disease type C, a neurodegenerative disorder characterized by the accumulation of cholesterol and sphingolipids in lysosomes.
Drug Metabolite
Others
HIT218633353
5(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester
T84500
14602-39-2
Mead acid, a 20-carbon ω-9 polyunsaturated fatty acid, experiences elevated levels in human plasma under conditions of essential fatty acid deficiency. As 1,25(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester (Mead acid methyl ester), it frequently serves as a standard for fatty acid analysis, particularly after fatty acids have been transesterified into methyl esters.
Others
HIT212730776
Hydroxy Varenicline
T85294
357424-21-6
Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.
AChR
Others
HIT103388493
Rhodamine 101 inner salt
T87324
116450-56-7
Rhodamine 101 inner salt是一种明亮的荧光染料,激发和发射最大值分别为565和595 nm。它可用于各种生物学应用,如荧光显微镜、流式细胞术、荧光相关光谱和ELISA。
Others
HIT214982494
CPM
T86088
76877-33-3
CPM 是一种马来酰亚胺衍生物,作为蓝色荧光硫醇活性染料,激发和发射最大波长为 384nm 和 470nm。
Others
HIT218543120
12(Z),15(Z)-Heneicosadienoic Acid
T85287
191545-08-1
12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms.
Endogenous Metabolite
Others
HIT217606754
6-hydroxy Etodolac
T84996
101901-06-8
6-Hydroxy Etodolac, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, causes false positives in diazo diagnostic tests for urinary bilirubin.
COX
Drug Metabolite
Others
HIT218633278
Hypogeic acid
T84533
2416-19-5
Hypogeic acid 可从与生物滤器中硫酸盐积聚相关的自养型细菌培养物中分离得到。
Endogenous Metabolite
Others
HIT218638201
Δ12-Prostaglandin D2
T84646
64072-89-5
Prostaglandin D2 (PGD2) is a primary enzymatic prostaglandin derived from PGH2 and is abundantly produced in the cerebrospinal fluid (CSF) by the lipocalin-type PGD synthase, and peripherally by myeloid cells such as mast cells and basophils via a hematopoietic-type PGD synthase. PGD2 is chemically unstable and presents challenges for use and analysis due to its brief in vivo half-life. Δ12-PGD2, an initial decomposition product of PGD2, acts as an intermediate in the pathway to Δ12-PGJ2, a cyclopentenone prostaglandin known for its antimitotic and carcinogenic properties. The metabolism of Δ12-PGD2 involves the addition of thiol nucleophiles, a common pathway for many cyclopentenone prostaglandins.
Others
HIT218832951
1-NBD-decanoyl-2-decanoyl-sn-Glycerol
T84489
2309189-98-6
Diacylglycerols (DAG) are generated through the hydrolysis of membrane phospholipids and function as lipid second messengers by activating protein kinase C (PKC) and modulating cell growth and apoptosis. Additionally, they act as precursors for DAG kinases in the synthesis of phosphatidic acid, a crucial lipid messenger. The compound 1-NBD-decanoyl-2-decanoyl-sn-glycerol incorporates a nitrobenzoxadiazole (NBD) fluorophore at the ω-end of its terminal decanoyl chain, using the structure of 1,2-didecanoyl-sn-glycerol as a model for diacylglycerol. This molecule is expected to exhibit excitation and emission peaks at roughly 470/541 nm, paralleling those of various NBD-labeled phospholipids. Fluorescently labeled lipids, such as this, are instrumental in exploring their interactions with proteins, their uptake by cells and liposomes, and in developing assays for lipid metabolism research.
Others
HIT217603016
Arachidonoyl Chloride
T85246
57303-04-5
Arachidonoyl chloride, a derivative of arachidonic acid, serves as an intermediate in synthesizing arachidonic acid derivatives.
Others
HIT217605832
Aluminon
TXB-00302
569-58-4
Aluminon (ATA; Ammonium aurintricarboxylate; Aurintricarboxylic acid ammonium) 是一种络合滴定指示剂,也用作核酸酶抑制剂,能够影响转染过程。Aluminon 可在生命科学研究中作为生物材料或有机化合物使用。
Others
HIT218832567
PF-03550096
T84412
910376-39-5
PF-03550096,一种口服活性的合成大麻素(CB),专一性作用于外周CB2受体,Ki值为7.9 nM,展现出镇痛效果。
Cannabinoid Receptor
Others
HIT218657265
M-144
T84446
2180924-19-8
UR-144, a synthetic cannabinoid, exhibits high affinity for the peripheral cannabinoid receptor (CB2) with a Ki of 1.8 nM, markedly greater than its affinity for the central cannabinoid receptor (CB1), for which it has a Ki of 150 nM. XLR-11 differs from UR-144 by featuring a fluorine atom on the terminal carbon of the alkyl chain and a methyl group on the C2 carbon of the indole. The specific biological activities of XLR-11 remain uncharacterized. It is designed for forensic and research use only.
Others
HIT217603083
1,2-Distearoyl-3-Palmitoyl-rac-glycerol
T85049
2177-99-3
1,2-Distearoyl-3-palmitoyl-rac-glycerol, a triacylglycerol, features stearic acid at the sn-1 and sn-2 positions and palmitic acid at the sn-3 position. This compound is identified in cocoa butter, lard, and cod liver oil.
Lipase
Others
HIT218541929
N-Oleoyl Taurine
T84548
52514-04-2
N-Oleoyl taurine, an amino-acyl endocannabinoid isolated from rat brain, along with several arachidonoyl amino acids such as N-arachidonoyl dopamine and N-arachidonoyl serine, have been derived from bovine brain. Mass spectral lipidomics analysis of rat brain revealed a series of fatty acyl amides of taurine, marking the discovery of a new class of compounds. These compounds, found in the kidney, are known to activate members of the transient receptor potential (TRP) family of calcium channels, with N-Oleoyl taurine specifically potentially activating TRPV1 and TRPV4 channels.
Endogenous Metabolite
Others
HIT218638337
Linoleic acid alkyne
TN7561
1219038-31-9
Linoleic acid alkyne,一种亚油酸的ω-炔衍生物,适用于通过点击化学合成其他含炔产品,例如甘油磷脂。
Others
HIT218638466
1,2-Dioleoyl-3-Docosohexaenoyl-rac-glycerol
T85225
116198-39-1
1,2-Dioleoyl-3-docosohexaenoyl-rac-glycerol, a triacylglycerol, consists of oleic acid at the sn-1 and sn-2 positions and docosahexaenoic acid at the sn-3 position. This compound has been identified in human breast milk.
Endogenous Metabolite
Others
HIT218832574
Naringenin-7-O-β-D-Glucuronide
TN7262
1237479-07-0
Naringenin-7-O-β-D-glucuronide, a metabolite of the flavonoid naringenin, is predominantly synthesized through the action of UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A3, UGT1A6, and UGT1A9.
Others
HIT218832624
U-51605
T84575
64192-56-9
U-51605, a stable analog of the endoperoxide prostaglandin H2 (PGH2), functions as an inhibitor with greater selectivity towards prostacyclin (PGI) synthase over thromboxane (TX) synthase. It also acts as a partial agonist at TP receptors. Studies show that at a concentration of 2.8 µM, U-51605 effectively inhibits PGI synthase in human foreskin fibroblasts, while a concentration of 5.6 µM is required to inhibit human platelet TX synthase. Furthermore, U-51605, at up to 1 µM, decreases the release of prostacyclin in SHR aorta triggered by the calcium ionophore A-23187 without impacting TXA2 production, and notably enhances the release of PGE2 and PGF2α.
Others
PGE Synthase
HIT212013045
12-Bromododecanoic Acid
T85020
73367-80-3
12-Bromododecanoic acid, a halogenated derivative of lauric acid, serves in the synthesis of clickable myristic acid derivatives and functions as a model fatty acid ligand for elucidating the X-ray crystal structure of bovine β-lactoglobulin-ligand complexes. This compound, at a concentration of 10 µg/ml, has been shown to diminish virion DNA in the culture supernatant of primary hepatocytes from a duckling model of hepatitis B virus (HBV) infection and exhibits inhibitory activity against HIV replication in CEM-SS T cells with an EC50 value of 38 µM.
HIV Protease
Others
HIT214308289
trans-9-Octadecenol
TCL-00193
506-42-3
Trans-9-Octadecenol 是一种有机化合物,属于醇类。它具温和脂肪气味,常见于肉类和奶制品等食物中。在香精香料行业中,Trans-9-Octadecenol 被广泛用于香水、古龙水和空气清新剂等产品作为香味剂。此外,它可能对抑制炎症相关疾病和癌症有潜在用途。
Others
HIT218832847
Bassianin
TN7524
54278-73-8
Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.
Antifungal
Others
HIT214322810
Janelia Fluor® 646, SE
T39242
1811539-59-9
Janelia Fluor 646, SE (JF646, SE) is a red fluorescent dye can be used in cellular imaging.
Others
HIT212876648
7-Methyl-6-thioguanosine
T19025
55727-10-1
MESG, a chromophoric substrate, can be used to quantitate inorganic phosphate.
Others
HIT220912887
DSPE-SPDP
T77286
144735-79-5
DSPE-SPDP,一种磷脂分子,能够在水中自行定向并形成脂质双层,适用于多种生化研究。
Liposome
Others
HIT100879008
L-Theanine (Standard)
TMSM-0467
3081-61-6
L-Theanine (Standard) 是 L-Theanine 的标准品。适用于定量分析、质量控制及生化实验等相关研究。L-Theanine 是一种存在于绿茶叶片中的非蛋白氨基酸物质,能阻断大脑中谷氨酸与谷氨酸受体结合,具有神经保护和抗氧化活性。 它通过口服能抑制皮层神经元兴奋从而产生抗应激作用。
Others
HIT101331064
Ninhydrin
T19036
485-47-2
Ninhydrin 是一种显色分析探针,可用于氨基酸和蛋白质的定量分析。
Others
HIT104481372
ent-Avocadyne
T126097
129099-96-3
ent-Avocadyne是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126097,CAS号为 129099-96-3。
Others
HIT213890923
RSM-932A
T9548
850807-63-5
RSM-932A (TCD-717) 是一种特异性 ChoKα 抑制剂,对人重组 ChoKα 和 ChoKβ 酶的 IC50 分别为 1 和 33 μM。RSM-932A 具有有效的体内外抗肿瘤活性,并且毒性较低。
Others
HIT214324121
Dehydroandrographolide succinate potassium sodium salt
T40971
863319-40-8
Dehydroandrographolide succinate (potassium sodium salt), derived from the herbal medicine Andrographis paniculata (Burm f) Nees, is a versatile compound highly utilized for the treatment of viral pneumonia and viral upper respiratory tract infections due to its potent immunostimulatory, anti-infective, and anti-inflammatory properties.
Others
HIT102094988
Marrubiin
TN1914
465-92-9
Marrubiin is a natural product
Others
HIT105355537
N-Methylpyrrolidone
T5851
872-50-4
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) 是一种有机极性溶剂,是一种五元环酰胺,普遍用于粘合剂,油漆,燃料和药品的生产。
Others
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