Others

Br-PEG3-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.

Sulfur trioxide-Triethylamine complex是一种路易斯酸碱加合物，常用作磺化剂或路易斯酸催化剂，广泛应用于生物化学实验和药物合成研究。

Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism.

Thalidomide-O-amido-PEG4-C2-NH2 is a synthesized conjugate compound that combines a Thalidomide-based cereblon ligand with a linker commonly used in PROTAC technology. It acts as an E3 ligase ligand-linker conjugate, enabling targeted protein degradation.

Hydroquinine 是金鸡纳生物碱，可用于制备衍生物（如 C9 脱氢喹啉、9-乙酰氧基-10,11-二氢喹、 10,11-二氢喹单盐酸盐等）。

TC HSD 21 是一种有效且高度选择性的 17β-羟基类固醇脱氢酶 3 型抑制剂 (IC50 = 14 nM)。

Nucleoside Derivatives - Fluoro-modified nucleosides; 3'-Modified nucleosides; Protected nucleosides w/NH2/OH open

4-(Dimethylamino)butanoic acid hydrochloride是一种胺类化合物，对人gamma-butyrobetaine hydroxylase具有弱抑制作用(IC50=203 μM)，可用于生物化学实验和药物合成研究。

AR524 是一种转基因抑制剂，抑制活性高于已知的转基因抑制剂 kifunensine。AR524 能够抑制低浓度 (10 μM) 的人类恶性细胞球状体的形成。

Ac4GlcNAlk is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Taprostene (CG-4203) 是一种合成的、化学稳定的前列环素 (PGI2) 类似物。Taprostene 对猫急性心肌缺血再灌注后内皮和心肌有保护作用。Taprostene 增强细胞保护作用，同时减少不必要的血液动力学影响。

Aminooxy-PEG8-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ranitidine bismuth citrate 为一种口服活性的组胺H2受体(Histamine H2-receptor)拮抗剂，其IC50值为3.3 μM，对SARS-CoV-2感染细胞显示高选择性。该化合物还是治疗幽门螺杆菌(Helicobacter Pylori)感染的常用试剂，其MIC90为16 ng/L。

Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PEG-based linker compound that finds utility in the synthesis of PROTACs[1].

FGIN 1-27 是一种吲哚乙酰胺，是外周苯二氮卓受体的特异性的配体，Ki 为 5.0 nM。FGIN 1-27 可以透过血脑屏障。FGIN 1-27对异烟肼引起的抽搐发作具有抑制作用。

KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.

Sudocetaxel 是一种可以用于pH 敏感的多西紫杉醇释放的微管解聚抑制剂。

Heptane-1-Thiol是一种硫醇，广泛应用于生物化学实验和药物合成研究。

L-Lactic acid-13C3 是 L-lactic acid 的稳定同位素标记类似物，其中三个碳原子被非放射性的 ¹³C 同位素取代，可用于精确追踪代谢通路中的乳酸通量。L-Lactic acid-13C3 被广泛应用于代谢谱分析、同位素示踪实验及糖酵解重编程研究，在生理和病理条件下为乳酸周转的定量分析提供了较高的分析灵敏度。

m-PEG8-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs.

iNOS-IN-2 (Compound 53) 是一种有效的诱导型一氧化氮合酶 (iNOS) 蛋白下调剂。iNOS-IN-2 能够有效抑制 NO 产生 (IC50: 6.4 μM)。iNOS-IN-2 能够用于慢性炎症的研究。

Tepilamide fumarate (XP-23829) 是一种口服具有活性的延胡索酸酯，可用于研究中度到重度慢性斑块银屑病。

JNJ-10191584, a potent and selective antagonist at the histamine H4 receptor, has antiinflammatory and analgesic effects in animal studies of acute inflammation.

m-PEG4-azide, also referred to as 13-Azido-2,5,8,11-tetraoxatridecane, functions as a PEG-based PROTAC linker suitable for PROTACs synthesis[1].

ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently, it disrupts or prevents TGF-β signaling. ALK5-IN-8 shows promise in the study of diverse diseases associated with ALK5-mediated pathways[1].

MAX-40279 hemifumarate 是有效的 FLT3 激酶和 FGFR 激酶的双重抑制剂。MAX-40279 hemifumarate 对急性髓性白血病 (AML) 表现出研究潜力。

(S)-V-0219 是 V-0219 的对映异构体。V-0219 是一种口服有效的 GLP 受体 (GLP Receptor,GLP-1R) 的正变构调节剂 (PAM)。(S)-V-0219 可激活表达 hGLP-1R 的 HEK 细胞中的钙流。(S)-V-0219 具有口服活性，可改善小鼠体内的高葡萄糖水平，并抑制禁食小鼠的进食行为。

L-796568, is a β3 adrenergic receptor agonist. L-796568 is a potent full beta(3) agonist (EC(50) = 3.6 nM, 94% activation) with >600-fold selectivity over the human beta(1) and beta(2) receptors, which also displays good oral bioavailability in several

2-(2,4-Dihydroxybenzoyl)benzoic acid (NSC 14699)是一种苯甲酸衍生物,对E型肉毒杆菌神经毒素(BoNT/E)具有抑制作用。

Anticanceragent 112，是一种用于癌症研究的强效抗癌试剂。

N6-Benzoyl-7'-OH-N-trityl morpholino adenosine is a Morpholino-nucleoside.

OAB-14 是一种 Bexarotene 衍生物，通过清除 APP/PS1 转基因小鼠的 β-淀粉样蛋白，改善其阿尔茨海默病相关的病理学和认知障碍。OAB-14 可有效改善 APP/PS1 转基因小鼠内体自噬溶酶体（EAL）途径的功能障碍。

9,10-Dimethoxycanthin-6-one shows cytotoxic activity against a HT-1080 human fibrosarcoma cell line( IC50 = 5.0 microM).

ELN484228 是一种 α-突触核蛋白的阻断剂。α-突触核蛋白是帕金森病中的关键蛋白质。

BnO-PEG5-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.