Others

Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.

Ethybenztropine HCl is an anticholinergic which is used as an antiparkinsonian agent. Ethybenztropine may also act as a dopamine reuptake inhibitor.

Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.

V-125 is an agonist of retinoid X receptors.

BAY-846 is an allosteric MEK inhibitor with long half-lives, high bioavailabilities, low brain penetration potential and high efficacy in a K-Ras-mutated A549 xenograft model.

Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%.

Demeclocycline calcium is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.

CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are 'effector caspases' that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is currently available for caspase inhibition by CAY10406.

Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th

Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis.

WAY 629 is a selective SR-2C agonist that also act as potent 5-HT2C receptor agonists.

Colterol HCl is the salt form of Colterol (free base), a short-acting β2-adrenoreceptor agonist. Bitolterol, a prodrug for colterol, is used in the management of bronchospasm in asthma and chronic obstructive pulmonary disease.

AVE-1330A sodium is a beta-Lactamase inhibitor.

GNTI TFA is a selective kappa opioid receptor antagonist.

Grp94-IN-2 is a inhibitor of Grp94.

Aplindore is a dopamine receptor agonist used in the therapeutic treatment of Parkinson's Disease.

(±)13-HpODE 在生命科学相关研究中具有广泛的应用。

D-Cystine, the D-enantiomer of L-Cystine, functions as an inhibitor of L-aspartate-β-semialdehyde dehydrogenase (ASADH) derived from Escherichia coli.

Tetrachloroveratrole, a byproduct of bacterial O-methylation, arises from the biodegradation of Tri- and Tetra chloroguaiacols. These chloroguaiacols emerge as a result of the wood pulp bleaching process within the paper manufacturing industry.

Phenyramidol Hydrochloride is an anticoagulant and analgesic.

Potassium-Hydroxypentyl Benzoate is a drug potentially for the treatment of acute ischemic stroke (AIS)

PKUMDL-LTQ-301 is a potent inhibitor of HipA toxin. PKUMDL-LTQ-301 also inhibits E. coli persistence.

PPZ2 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator.

SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1 with promising anxiolytic, antidepressant and anorectic effects in initial animal studies.

RO 23-6152, a new calcium antagonist, can inhibit platelet aggregation in vitro associated with occlusive coronary thrombus formation.

Ro 23-7014, a new thiazepinone Ca2+ channel antagonist, has high affinity for peripheral (Type A) receptors.

RDEA-806, a reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.

Setafrastat is a vascular endothelial growth factor (VEGF) promotor and rotamase inhibitor.

Sezolamide hydrochloride is a potent topical carbonic anhydrase inhibitor.

RG 14467 is an antagonist of epidermal growth factor-urogastrone.

Sch 39304 is an oral triazole antifungal.

PNU-107484A is a unique GABA(A) receptor ligand.

Proxodolol, a β-adrenergic receptor antagonist, is used potentially for the treatment of glaucoma, hypertension and angina.

Profadol hydrochloride acts as a mixed agonist-antagonist of the μ-opioid receptor with analgesic activity.

RO-09-4609 is a potent and selective inhibitor of Candida albicans N-myristoyltransferase (CaNmt).

Ro 63-0563 is a potent, 5-HT6 receptors selective antagonist.