Antibacterial

Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus. It is active against S. aureus when used at a concentration of 32 μg/ml. Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 μg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg. Gilvocarcin M intercalates into bacteriophage PM2 DNA. It is toxic to rats with an intravenous LD50 value of 450 mg/kg.

Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.

Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. [1]. Apramycin, From Wikipedia

Leucomycin A4 is a macrolide antibiotic that has been found in S. kitasatoensis. It is active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 μg/ml, respectively).

Isodictamnine is phototoxic to certain bacteria and yeasts in long wave UV light.

Musellactone shows different effects against five bacteria strains.

3,9-Dihydroxypterocarpan and phaseollidin are all good precursors of the pterocarpan phytoalexin phaseollin.

Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL.

Isozaluzanin C (Dehydrozaluzanin C-derivative) 作为一种从雪莲 (Saussurea lappa) 分离的抗炎剂，具备免疫调节功能。该化合物能够有效改善由 LPS 或 CRKP 感染引发的小鼠的组织损伤（涉及肺、肾和肝）以及过度的炎症反应。Isozaluzanin C 主要应用于细菌感染和脓毒症的相关研究。

(-)-cis-Myrtanol, 一种源于Artemisia dracunculus的萜类化合物，表现出对Bifidobacterium bifidum等肠道有害细菌的有效抗菌活性。

Destomycin A 是一种具备多重生物活性的氨基糖苷类抗生素，能有效对抗革兰氏阳性菌及革兰氏阴性菌，同时具有抗真菌和驱虫的特性。此外，Destomycin A 可抑制 Escherichia coli 细胞中的多肽合成，并能激活动物组织内的腺苷酸环化酶。

1,2-Dihydroxynaphthalene 作为从萘代谢过程中分离得到的中间产物，已被确认为萘醌形成的前体。此化合物可以被某些细菌（例如假单胞菌属）进一步转化为香豆素和水杨酸等化学物质。

2-C-Methyl-D-erythritol 4-phosphate 是原核生物特有的非甲羟戊酸 MEP 代谢途径中的一个中间体，主要用作异戊二烯及非异戊二烯（包括维生素）的合成前体。由于这种化合物在人体中并不存在，它被视为开发治疗传染病的细菌特异性药物的理想靶标。

Cyclo(Leu-Ala) (Cyclo(alanine-leucine)) 是一种从微生物中分离出的具有抗菌特性的化合物，能够与其他化合物协同，对一些植物病原体展示出抗菌活性。

ISOPLUMBAGIN，一种来源于无刺指甲花(Lawsonia inermis)和欧洲血根草(Plumbago europaea)的天然产生的醌类化合物。这种化合物已被报道具有抗炎和抗微生物的活性。

meso-2,6-Diaminopimelic acid 为L-赖氨酸生物合成过程中的倒数第二前体，同时也是多类细菌细胞壁里肽聚糖的关键成分。

δ-(E)-Deoxy-amplexichromanol 为一种来源于C. atlantica锥果水甲醇提取物的δ-tocotrienolic acid 衍生物，展现出显著的抗菌活性。

Pyrromycin is a monosaccharide anthracycline which can be used to inhibit cellular RNA synthesis.

Ipconazole is a member of the class of cyclopentanols carrying 1,2,4-triazol-1-ylmethyl, 4-chlorobenzyl and isopropyl substituents at positions 1, 2 and 5 respectively. Used to control a range of seed diseases in rice, vegetables and other, mainly non-food, crops. It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of cyclopentanols, a member of monochlorobenzenes, a member of triazoles, a tertiary alcohol, a conazole fungicide and a triazole fungicide.

Fabimycin 是一种FabI 抑制剂，对革兰氏阴性菌具有有效的抗菌活性。Fabimycin 可抵抗耐药性革兰氏阴性菌感染 (in vivo)。

Salifluor is a broad spectrum antimicrobial agent that has been investigated for its abilities to inhibit dental plaque formation.

Aquayamycin is an anthraquinone derivative and inhibitor of the enzyme tyrosine hydroxylase..

Cyclamidomycin is an antibiotic. It also functions as an inhibitor of nucleoside diphosphokinase of Escherichia coli.

Monamycin V 是一种酯肽抗生素，对革兰氏阳性菌表现出活性。

Pyrronamycin A 对革兰氏阳性菌和阴性菌（如金黄色葡萄球菌、肠球菌、大肠杆菌、肺炎克雷伯菌、变形杆菌、志贺氏菌和沙门氏菌）展现出抗菌活性。

Quinolactacin B 是一种喹诺酮，由青霉菌 [EPF-6] 产生。

4-(Cyclohexyldisulfaneyl)pyridine 是一种 III 型分泌系统（T3SS）抑制剂，它能够抑制 E. amylovora CFBP1430 中 hrpA 和 hrpL 启动子的活性。4-(Cyclohexyldisulfaneyl)pyridine 可用于火疫病的研究。

3-Ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one 是一种吲哚衍生物，具有抗革兰氏阳性菌和革兰氏阴性菌的活性。

BT-33 是一种具有广谱抗多重耐药细菌 (bacterial) 病原体活性的氟化大双环氧杂环丙氨酰胺抗生素。

Oxasetin 对革兰氏阳性菌表现出中等水平的活性，包括耐甲氧西林金黄色葡萄球菌和耐万古霉素粪肠球菌 (MIC 为 16 μg/mL)。此外，Oxasetin 对革兰氏阴性菌和真菌无任何活性。

Topoisomerase inhibitor6 (Compound REDX05931) 是一种双重不可逆的DNA gyrase和topoisomeraseIV抑制剂，对耐氟喹诺酮类的S. aureus的MIC为0.06 μg/mL。此化合物通过阻断DNA链断裂-重接过程引起致命的DNA损伤，有潜力用于研究革兰氏阳性菌感染，如S. aureus和S. pneumoniae。

CYP1A1-IN-1 (Compound 47) 是一种细胞色素 P4501A1 (CYP1A1) 抑制剂的小分子。CYP1A1-IN-1 可以增强巨噬细胞的吞噬功能，从而降低耐甲氧西林Staphylococcus aureus (MRSA) 和Acinetobacter baumannii的细菌载量。CYP1A1-IN-1 有潜力用于多重耐药 (MDR) 细菌引起的败血症的研究。

Isolubimin是一种源自Datura stramonium果实的倍半萜类植物抗菌素，具有显著的抗菌活性。Isolubimin被认为在研究由真菌感染导致的植物病害方面具有潜在应用价值。

Pluracidomycin A2 (PLM A2) 是一种碳青霉烯类抗生素，具备对革兰氏阳性菌和革兰氏阴性菌的活性。

N'-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) 是一种针对细菌血红素加氧酶 (HO) 的竞争性抑制剂 (IC50=5-30 μM)。它可以抑制铁释放和细菌铁摄取，并对来自Pseudomonas aeruginosa和Neisseria meningitidis的HO酶有选择性活性，因此有潜力用于多重耐药革兰氏阴性细菌感染的研究。

α-Mycolic acid, keto cis 是分枝杆菌细胞壁中的结构脂质成分，可从 Mycobacterium tuberculosis Canetti 中分离。它显著调节膜的通透性和稳定性，并在结核分枝杆菌感染研究中展现出潜在应用价值。