Others

Monoelaidin (1-Monoelaidin) 是一种由一分子十八酸和一分子甘油通过酯化反应生成的化合物，具有保湿作用，常添加在护肤品中。

18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.

1-(1-Ethoxyethoxy)butane是一种醚类化合物，主要用作有机合成中间体，可用于生物化学实验和药物合成研究。

Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations.

6alpha-Hydroxymedicarpin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3200，CAS号为 61135-92-0。

PGAM1-IN-2 是一种有效的磷酸甘油酸变位酶 1 (PGAM1) 抑制剂 (IC50=2.1 μM)。

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker applicable for synthesizing PROTACs[1].

Mal-amido-PEG12-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.

L-Tetraguluronic acid是一种由4个重复单元组成的直链多糖共聚物，参与构成alginate。L-古罗糖醛酸四糖与Glu543在非催化结构域中相互作用的能够帮助AlyRm1 更有效地结合底物和提高催化效率。

N2-iso-Butyroyl-3'-O-(methoxyethyl)guanosine is a Nucleoside Derivative - 3'-Modified nucleoside.

Apronal (Apronalide) 具有催眠和镇静作用，可用于神经精神疾病的相关研究。

Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor

Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 μM), thereby activating Wnt/β-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.

CDAP是一种氰基化试剂，常用于修饰蛋白质巯基，还能够在疫苗制备中制备蛋白质-多糖缀合物和激活多糖。

BM-131246 是一种可口服的且具有抗糖尿病活性的噻唑烷二酮衍生物，可用于研究糖尿病。

11(α)-Methoxysaikosaponin F是一种天然的三萜皂苷，能够在高浓度下抑制HSCs-T6细胞的活力(IC50=387.7 μM)。

NS3861 fumarate 是烟碱型乙酰胆碱受体 (nAChRs) 的激动剂。NS3861 fumarate 是α3β4 nAChR 的部分激动剂。与α3β4、α3β2、α4β4、α4β2 的结合Ki 值分别为 0.62、25、7.8、55 nM。

WX-081 是抗结核剂 (anti-tuberculosis)，对 M. tuberculosisH37Rv 表现出明显的抗分枝杆菌效果，并能够作用于药物敏感结核病 (DS-TB) 杆菌 (MIC: 0.083 μg/ml) 和耐多药结核病 (MDR-TB) 菌株 (MIC: 0.11 μg/ml)，对 hERG 通道表现出抑制作用 (IC50: 1.89 μM)。

1-Phenylnaphthalene是一种多环芳烃化合物（PAH），广泛应用于生物化学实验和药物合成研究。

2,3-Dihydroxynaphthalene是一种萘衍生物，是染料和感光材料合成的重要中间体，广泛应用于生物化学实验和药物合成研究。

HO-PEG10-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TAK-024 is an inhibitor of platelet(IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively).

Choline Iodide对Leishmania panamensis具有抑菌活性，还可以作为Acetylcholinesterase的抑制剂，可用于研究退行性神经疾病。

(Rac)-Upacicalcet is a racemate of Upacicalcet, which serves as an intravenous calcimimetic agent. Upacicalcet acts by directly targeting calcium-sensing receptors on parathyroid cell membranes, effectively suppressing the release of excessive parathyroid hormone (PTH) and reducing blood PTH levels. This compound holds the potential for researching secondary hyperparathyroidism (SHPT) [1].

PD-159020 is a non-selective antagonist of ETA/ETB(hETA and hETB with IC50s of 30 and 50 nM , respectively).

PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.

Anticancer agent 66 是一种抗癌剂。Anticancer agent 66 在 MCF-7 细胞中诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。Anticancer agent 66 是一种环丙沙星类似物。

JNJ-54717793 是一种具有口服活性、脑穿透性、选择性和高亲和力的orexin-1 receptor(OX1R) 拮抗剂(血浆EC50=85 ng/mL)。JNJ-54717793 的 hOX1R 和 hOX2RKi 值分别为 16 nM 和 700 nM。JNJ-54717793 是一种有效的焦虑症化合物。

Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.

Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.

Eucatropine，作为一种有效的毒蕈碱型乙酰胆碱受体(mAChR)抑制剂，具有0.583 μM的IC50值，归类为抗胆碱能剂。

Revizinone is a novel selective phosphodiesterase inhibitor with IC50 values on this enzyme to 0.036 microM.

Glymidine sodium 是口服有活性的抗糖尿病药物，也是肝脂肪分解的抑制剂。它通过抑制葡萄糖的形成，也对由于内源性脂质动员抑制而导致的丙酮酸氧化升高具有抑制作用。