Others

VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel activator (EC50s: 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively). It is also effective on the GIRK4 homomeric channel.

Thalidomide-O-C8-NH2 is a chemically synthesized conjugate that combines a cereblon ligand derived from Thalidomide with a linker utilized in PROTAC technology. It functions as an E3 ligase ligand-linker conjugate.

Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series.

EGFR-IN-38 是一种低毒副作用的、丙烯酰胺衍生物的抗肿瘤药物，是 EGFR 的有效抑制剂。其中表皮生长因子受体 (EGFR) 的过度表达和突变已被证实会导致细胞无节制的生长，并与大多数癌症疾病，尤其是 NSCLC 的进展有关。EGFR-IN-38 表现出 EGFR 突变相关疾病的研究潜力。

Ro 24-4383 is a carbamate-linked dual-action antibacterial agent.

m-PEG4-phosphonic acid ethyl ester is a PEGylation-based linker for the design and synthesis of PROTACs, which are heterobifunctional molecules facilitating targeted protein degradation[1].

Phenylsilane是最简单的有机硅烷之一，可用于有机合成和生化实验，对小鼠具有口服和吸入毒性。

AB 3217-A, an anti-mite substance isolated from the fermentation broth of a streptomycete strain, shows marked activity against the two spotted spider mite, Tetranychus urticae.

CO delivery molecule 1 (compound 4) exhibits subcellular localization in the endoplasmic reticulum, mitochondria, and lysosomes. Such localization leads to the manifestation of CO-induced toxicity effects. Notably, the anti-inflammatory properties of CO delivery molecule 1, quantified through TNF-α suppression, are evident at nanomolar concentrations even without CO release. Furthermore, visible-light-induced CO release further enhances its anti-inflammatory effects [1].

3-(4-aminophenyl)-1-methyl-1H-pyrazole-4-carboxylic acid 是一种含氮杂环有机化合物，在药物和农用化学研究中作为合成其他活性化合物的重要中间体。3-(4-aminophenyl)-1-methyl-1H-pyrazole-4-carboxylic acid有助于构建结构多样的吡唑衍生物，其多功能基团排列对于生物活性分子骨架的设计具有重要价值。

Biotin-PEG12-acid is a PEG-based PROTAC linker labeled with biotin, designed for synthesis of PROTACs[1].

Amino-PEG4-C1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serves as a valuable tool for researchers in the field of Alzheimer's disease (AD) [1].

Vomifoliol 是一种植物来源化合物，可能作为脱落酸代谢转化生成 dehydrovomifoliol 的直接前体。Vomifoliol 与 Stigmasterol 联合可对人肺癌细胞系显示抗增殖活性，因此在植物代谢物生物转化与抗癌活性研究中具有重要意义。

Diphenyl Blue (Direct Blue 14) 是一种可用作偶氮染料组的参考染料。

Glatiramer acetate 是髓鞘碱性蛋白的合成类似物和免疫调节剂，可用于多发性硬化症的研究。它能够诱导 T 辅助细胞 2 的特异性抑制细胞迁移到大脑并导致原位旁观者抑制。它能够于 MHC 分子强而杂乱的结合，因此与各种髓鞘抗原竞争，使其呈现给 T 细胞。

3(20)-Phytene-1,2-diol是一种天然产物，属于菊科向日葵属，其产品编号为 TN2858，CAS号为 438536-34-6。3(20)-Phytene-1,2-diol可用作对照参考。

AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).

(+)-Donepezil is an isomer of Donepezil -- a nootropic acting as an inhibitor of acetylcholinesterase.

Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。

Anti-neurodegeneration agent 1 a neurodegeneration-targeting agent.

Asperglaucin A 代表一种不寻常的类苯酞衍生物。Asperglaucin A 对两种植物病原体Pseudomonas syringae pv actinidae(Psa) 和Bacillus cereus 具有有效的抗菌活性，MIC 值为 6.25 μM。

Phensuximide is an anticonvulsant.

Prednimustine (Leo 1031;NSC 134087) 是由 Prednisolone 和 Chlorambucil 形成的酯。Prednimustine 可用于白血病和淋巴瘤的研究。

Acibenzolar-S-methyl是一种植物抗性诱导剂和水杨酸类似物，通过激活植物在细胞间隙产生致病相关蛋白，引起植物的全身获得性抗性，从而增强植物的抗病能力。

Nucleoside Derivatives - Azido nucleosides, 5-Modified pyrimidine nucleosides, 2'-Modified nucleosides

Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物，可促进 B16F10 细胞的黑色素生成，抑制人肺腺癌中成骨细胞介导的破骨细胞生成。

Ceftaroline fosamil hydrate acetate 是一种高效的头孢菌素类抗生素(antibiotic)，对多种病原体有广谱活性，特别是针对革兰氏阳性病原体，如耐甲氧西林金黄色葡萄球菌(MRSA)和耐多药肺炎链球菌，以及常见的革兰氏阴性微生物。此外，Ceftaroline fosamil hydrate acetate 在治疗复杂皮肤及皮肤结构感染(cSSSIs)和社区获得性肺炎(CABP)方面表现出显著的抗感染活性。

Diethylcarbamazine, an anthelmintic, is used primarily as the citrate in the treatment of filariasis, particularly infestations with Loa loa or Wucheria bancrofti.

ASN04421891 是一种 GPR17受体调节剂，在 [35S]GTPγS 结合实验中 EC50为 3.67 nM，具有神经退行性疾病的研究潜力。

2-(propan-2-yldisulfanyl)propane（异丙基二硫）是一种有机硫化物，具有特殊的气味，常用于化学合成和香料制备, 可作为有机合成中间体，用于制备其他化合物。

8-Methyl-2'-deoxyguanosine is a Nucleoside Derivative - 8-Modified purine nucleoside.

5-TRITC是一种胺反应性荧光染料，常用于标记蛋白质和核酸。它能够与蛋白质中的氨基基团反应，形成稳定的硫醚键，从而标记和检测特定蛋白质的存在和定位，产生激发/发射最大值约555/580 nm的亮红橙色荧光。

USP1-IN-6 (化合物11) 是一种具有双重功能的USP1抑制剂，不仅其IC50<50 nM，表明对USP1的高度抑制能力，同时也能有效抑制MDA-MB-436细胞生长，同样展现出IC50<50 nM的强效性。

BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274. It impairs the anchorage-independent growth of KEAP1-mutant cancer cells.

(S)-GNE-140 is the less active enantiomer of GNE-140.