Others

MRS1186 is an effective and selective antagonist of the human Adenosine A3 receptor (Ki: 7.66 nM).

Levocabastine HCl is an agent with antihistaminic activity.

Thailanstatin C, an antiproliferative agent derived from Burkholderia thailandensis MSMB43, functions as a potent inhibitor of pre-mRNA splicing (IC50 = 6.84 μM).

(-)-15-Deoxyspergualin trihydrochloride，一种抗肿瘤剂，对小鼠白血病L-1210显示出显著抑制效果。

ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt is an inhibitor of ecto-ATPase.

3-Hydroxy-4-methylbenzoic acid是一种苯甲酸衍生物，广泛应用于生物化学实验和药物合成研究。

cis-11-Methyl-2-dodecenoic acid 是群体感应 (QS) 信号分子，在微生物及真菌的细胞外通讯系统中扮演扩散信号因子(DSF)的角色。它参与调控多种细菌病原体的毒性及生物膜的生成。

Bentazone是一种选择性的出苗后除草剂，能够干扰光合作用，用于抑制阔叶杂草和莎草。

S(-)-Bisoprolol fumarate 是 Bisoprolol fumarate 的 S(-)-对映异构体，这种化合物是一种有效的、选择性的，并具有口服活性的 β1 肾上腺素受体 (β1-adrenergic receptor) 阻滞剂，对 β2 受体的活性较低。它主要用于研究高血压、冠状动脉疾病和稳定的心室功能障碍。

(E)-Ligustilide has renal protection and was isolated from Angelica sinensis.

Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793

(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one is a natural product

N-(Azido-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker utilized for PROTAC synthesis[1].

Picroside III 是一种环烯醚萜苷，分离自传统中药胡黄连中。Picroside III 具有修复肠粘膜损伤的潜力，可减轻小鼠肠道炎症。

Inotilone 是中药材 Inonotus linteus 的主要成分，可用于转移性肺癌细胞的研究。

TNF-α (31-45), human, is a peptide of tumor necrosis factor-α.

dmDNA31 is a rifamycin antibiotic that can inhibit the DNA-dependent RNA polymerase of bacteria and has strong bactericidal activity against Staphylococcus aureus.

Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。

Dezapelisib is an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K). INCB040093 prevents both the production of the second messenger phosphatidylinositol-3,4,5-trisp

3,4-Dihydroxymandelic acid (Standard) 是一种可用于分析的标准物质，通常用作 3,4-Dihydroxymandelic acid 的研究和分析中参考的标准样品。3,4-Dihydroxymandelic acid 是一种去甲肾上腺素的代谢产物，存在于所有生物体中。

LY88074 analog 1, a benzothiophene compound with nitrogen-containing non-basic side chains, can be utilized either independently or alongside estrogen or progestin. This agent is effective for mitigating post-menopausal symptoms, including osteoporosis, cardiovascular-related pathological conditions, and estrogen-dependent cancer.

Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based linker suitable for the synthesis of PROTACs, compound complexes that selectively degrade target proteins[1].

Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) 是黄柏的一种成分，具有抗癌和抗炎活性。

JMI-105 具有用作抗疟剂的潜力。JMI-105 是恶性疟原虫 -2 蛋白酶(PfFP-2)的有效抑制剂，可抑制恶性疟原虫菌株的CQS 株 (3D7) 和 CQR 株 (RKL-9) 的生长，IC50值分别为8.8 μM 和14.3 μM。在伯氏疟原虫 ANKA 感染小鼠模型中，JMI-105 显著降低寄生虫血症并延长宿主存活期。

non-steroidal androgen receptor (AR) antagonist

Antioxidant agent-11 (compound 3d) 是具备抗氧化以及轻度抗癌活性的化学化合物。

MRV03-068（化合物2）作为一种选择性的ClbP抑制剂，有效抑制Colibactin对真核细胞的基因毒性。该化合物在结直肠癌研究中具有潜在应用价值。

RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.

Phenacaine (Holocaine)为一种局部麻醉剂，能够在大脑及心脏红细胞中抑制特定的钙调素依赖性Ca2+-ATP酶与环核苷酸磷酸二酯酶刺激产生。

Axl-IN-11 是 AXL 的有效抑制剂。Axl-IN-11 能够用于研究增生性疾病、过敏性疾病、自身免疫性疾病、炎症性疾病、癌症、移植排斥、病毒性传染病或其他哺乳动物疾病。

D-Otocenine elicites low toxicity, it shows spasmolytic properties .

Isoetharine is a selective agonist of β2-adrenergic receptor used as a bronchodilator for emphysema, bronchitis, and asthma.

Spliceostatin A 是 抗癌剂和剪接抑制剂，抑制剪接体剪接机制，抑制有丝分裂克隆扩增和脂肪生成。Spliceostatin A 诱导细胞周期停滞在 G1 和 G2/M 期，诱导细胞凋亡。

Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 μM, respectively).1

GS-704277, an alanine metabolite derived from Remdesivir, a nucleoside analogue acknowledged for its potent antiviral efficacy, demonstrates remarkable effectiveness in vitro for the management of SARS-CoV-2 (COVID-19) infection[1][2].

COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].