Others

GSK-2793660 是一种具有口服活性并且不可逆的组织蛋白酶 C (Cathepsin C；CTSC) 抑制剂。GSK-2793660 是一种生物活性肽，可用于支气管扩张的研究。

ThrRS-IN-1 (Compound 30d) 是一种threonyl-tRNA synthetase (ThrRS)抑制剂，对Salmonella entericaThrRS (SeThrRS) 的IC50值为 1.4 μM，Kd 值为 1.36 μM。 ThrRS-IN-1 同时靶向 ThrRS 的 tRNAThr 和 L-threonine 结合袋。ThrRS-IN-1 具有抗细菌 (antibacterial) 活性。

Ibericin 是一种从Prismatomeris filamentosa 根中分离得到的蒽醌代谢产物，对革兰氏阳性菌和革兰氏阴性菌具有一定的抗菌活性。

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

BAY-298 是一种口服有效且选择性的促黄体生成激素受体(LH-R)拮抗剂，分别针对hLH(人LH)、rLH(大鼠LH)和cLH(食蟹猴LH)展现出96 nM、23 nM和78 nM的IC50。作为一种纳摩尔级别的hLH-R拮抗剂，BAY-298 能够有效降低体内性激素水平。

CM398 is an orally active chemical compound that acts as a highly selective ligand for the sigma-2 receptor (K i =0.43 nM), demonstrating a significant ratio of selectivity between sigma-1 and sigma-2 receptors (1000-fold). Moreover, CM398 exhibits notable affinity towards dopamine (K i =32.90 nM) and serotonin transporters (K i =244.2 nM). In addition, CM398 has shown promising efficacy as an anti-inflammatory analgesic in a mouse model of inflammatory pain induced by formalin [1].

allo-Yohimbine is a biochemical.

Pseudobufarenogin (ψ-Bufarenogin) 是一种蟾蜍毒素提取物，活性背景未知。

Alvameline (Lu25-109) is a partial M1 agonist. Alvameline (Lu25-109) also is a M2/M3 antagonist.

Glutathione arsenoxide is a hydrophilic derivative of phenylarsine oxide (PAO), a protein tyrosine phosphatase inhibitor. Glutathione arsenoxide inhibits angiogenesis and tumour growth.

TLR7/8 agonist 4 (compound 41) 是具有抗癌活性的，TLR7/8 的有效激动剂。

(S)-Trolox, an analogue of vitamin E, substitutes the phytyl chain with a carboxyl group. This compound serves as a model substance in structural studies and as a standard for assessing antioxidant activity. Moreover, (S)-Trolox exhibits potent and specific neuroprotective and antioxidant properties.

HDAC10-IN-2 (化合物 10c) 调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。HDAC10-IN-2是HDAC10的高选择性抑制剂 (IC50 = 20 nM)。

4-O-Methyldopamine hydrochloride是一个片段分子，CAS号为645-33-0，可作为分子拼接、扩展和修饰的重要骨架，为新型候选药物的设计与筛选提供结构基础与研究工具，常用于药物发现、药物合成等相关研究。

DNP-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DMP 696 is a selective antagonist of corticotropin-releasing hormone receptor 1. It is used for the treatment of anxiety and depression.

(Ala13)-Apelin-13 是一种有效的 APJ 受体拮抗剂，可以防止 apelin 诱导的胃张力和运动性降低。

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A .

N-(m-PEG4)-N'-(biotin-PEG3)-Cy5, a PEG-based PROTAC linker, serves as a valuable component in the synthesis of PROTACs[1].

Alisol C 23-acetate (Alisol C monoacetate) 是一种提取自东方泽泻中的天然产物，可以显著减少迟发型超敏反应。

Due to the multi-drug resistance reversal activity of the less polar ecdysteroids, several new products( including 20-hydroxyecdysone,20-hydroxyecdysone 2,3;20,22-diacetonide) are promising for being tested against various cancer cell lines.

Tazarotenic acid (AGN-190299) 是 Tazarotene 的代谢物。它与视黄酸受体 (RAR) 的结合位点是类视黄醇作用的可能的分子靶点。它对疣状角化不良具有潜在的研究价值。

Triheptadecanoin能够抑制慢性粒细胞白血病细胞K-562的增殖，具有抗癌潜力。

Hyocholic acid (Standard) 是一种可用于分析的标准物质，通常用作 Hyocholic acid 的研究和分析中参考的标准样品。Hyocholic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN7024，CAS号为 547-75-1。

Ruxolitinib (Standard) 是一种可用于分析的标准物质，通常用作 Ruxolitinib 的研究和分析中参考的标准样品。Ruxolitinib (INCB018424) 是一种 JAK1/2 抑制剂 (IC50=3.3/2.8 nM)，具有有效性和选择性。Ruxolitinib 具有抗肿瘤活性，可以诱导细胞自噬和凋亡。

Cbz-NH-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

3'-Bromo-3'-deoxythymidine is a Nucleoside Derivative - Halo-nucleoside, 2',3'-Dideoxy nucleoside.

p-HTAA 是一种五聚体氢噻吩乙酸。p-HTAA 可特异性标记小鼠活体大脑中的 Aβ 沉积物。

Mead acid 是一种属于 Omega-9 系列的不饱和脂肪酸，在生化上被表征为必需脂肪酸缺乏的标志物。Mead acid 在生物组织中的积累常被用作脂质代谢改变、营养失衡及脂肪酸稳态紊乱的指示指标，广泛应用于临床和实验研究领域。

Kaurenoic acid (kaurenoate) 是一种二萜，来源于 Sphagneticola trilobata 中，可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路，并抑制炎症疼痛。

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate, specifically designed for targeting the EED protein in PROTAC applications[1].

PI3K/mTOR Inhibitor-4 是一种口服具有活力的泛 I 类 PI3K/mTOR 抑制剂。PI3K/mTOR Inhibitor-4 具有酶抑制作用，能够作用于 PI3Kα (IC50: 0.63 nM)、PI3Kγ (IC50: 22 nM)、PI3Kδ (IC50: 9.2 nM) 和 mTOR (IC50: 13.85 nM)。PI3K/mTOR Inhibitor-4 能够用于研究癌症。

Sodium glycocholate hydrate是一种常用于生化实验的缓冲剂和共轭胆汁盐，可用于检测血清总胆汁酸和在其有效缓冲范围内维持稳定的pH值。

Strychnilactone是一种天然的倍半萜类内酯，可用于生物化学实验和药物合成研究。

Nortropine Hydrochloride是一种天然的双环生物碱，是托品碱(tropine)的分解中间体，可用于生物化学实验和药物合成研究。