Parasite

Hexacyclinol 具备对革兰氏阳性菌的中等抑制作用，其浓度在 4-40 μg/mL 时可以抑制酵母多糖刺激下多形核中性粒细胞 (PMNL) 的氧化剂产生。该化合物对 L-930 和 K562 细胞的生长抑制作用显著，IC50 分别为 1.4 μg/mL 和 0.4 μg/mL，而 HeLa 细胞的 IC50 为 10 μg/mL。此外，Hexacyclinol 对恶性疟原虫也表现出防治效果，IC50 为 2.4 μg/mL。

Anthelvencin A 是一种具有中等抗菌和驱虫活性的吡咯酰胺代谢物。

Aurachin C 是一种异戊二烯类喹啉生物碱，拥有抗疟原虫、抗真菌和抗菌特性。Aurachin C 充当选择性末端氧化酶抑制剂。

Pyrazole N-Desmethyl sildenafil (Compound 10) 为Sildenafil的类似物，其在浓度为100 µM时，对布氏锥虫磷酸二酯酶TbrPDEB1的抑制率达到16%。

MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor.

(R)-Praziquantel is an active enantiomer of praziquantel.

3HKT-IN-1 (Compound 17122279) 是一种抑制 Anopheles gambiae 3-hydroxykynurenine transaminase (3HKT) 的化合物，适用于疟疾研究。

SDH-IN-24 (Compound 51) 是一种琥珀酸脱氢酶 (SDH) 抑制剂，对松材线虫 (B. xylophilus) 第二阶段幼虫的LC50为6.9 mg/L，对SDH的IC50为15.0 μM。SDH-IN-24 通过抑制SDH活性影响线虫的能量代谢，并抑制其运动、取食和繁殖，诱导氧化应激，降低蛋白质含量及抗氧化能力，发挥杀线虫活性。该化合物可用于抗线虫相关领域的研究。

Amoscanate is an antiparasitic agent. It is highly effective in animals against the four major species of schistosomes which infect humans.

Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.

Floxacrine is drug candidate for chemoprophylaxis of malaria.

GSK575594A is a selective agonist of GPR55.

Clociguanil has antimalarial activity.

Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone that existed in some fruits from Annonaceae family.

Dabequin is a derivative of aminoquinoline. It is said to have pharmacological activity against Plasmodium fukiparum.

Clenpirin is a bio-active chemical.

M+B 5124 is a bioactive chemical.

Rac-Efavirenz is a non stereospecific structure of Efavirenz.

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate rhodamine 123 , in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.

DNDI-6174是一种细胞色素bc1复合物(cytochrome bc1 complex)抑制剂，对多种利什曼原虫展现出有效的体外活性，并能减少感染动物模型中的寄生虫负担。

Insecticidal agent 7 (Compound 21m) 作为一种杀虫剂，针对昆虫兰尼碱受体 (RyRs) 的活性突出，其对小菜蛾 (P. xylostella) 的LC50达到 0.0937 mg/L。此外，该化合物对非靶标生物展现出较低的毒性和较好的选择性。

TCMDC-137332是一种对恶性疟原虫具有抗活性的化合物，其IC50值为7 nM，可用于疟疾研究。

Antimalarial agent 36 (compound 1)，作为一种抗疟剂，对Dd2和3D7株的EC50s值分别是58 nM和42 nM，其作用靶点为EphA2。

Anti-infective agent 9（compound 1）作为恶性疟原虫的有效抑制剂（IC50=600 nM），能有效降低疟原虫中的丙酮酸水平和TCA循环活性。该化合物显示出良好的代谢稳定性，且对人类肝细胞的毒性较低。进一步研究表明，Anti-infective agent 9抑制恶性疟原虫生长的作用机制并非通过1-脱氧-d-木酮糖-5-磷酸合酶（DXPS）。

MMV1557817 具有口服活性的化合物，有效对抗疟疾。该化合物针对恶性疟原虫和间日疟原虫的氨基肽酶M1及M17表现出良好的选择性抑制作用，能有效阻断无性疟原虫在其生命周期终末期对血红蛋白的消化过程。

Omphalotin A，一种具杀线虫活性的环状肽。

GW648495 is a PfDHODH inhibitor that shows greater than 4,000-fold selectivity for the malarial enzyme.

Amorphadiene，作为抗疟药物青蒿素的前体，主要通过无定形二烯合成酶 (ADS) 催化yeast中的法尼基焦磷酸 (FPP) 进行环化反应而形成。

Isazofos 是具有广泛应用的有机磷酸酯类杀虫剂和杀线虫剂，能有效控制包括线虫Radopholus similis在内的多种草坪害虫。此外，Isazofos 在抑制水稻瘿螟的活动上也表现出色。

VNI作为一种CYP51抑制剂，有效地阻断了克氏锥虫内的甾醇合成，从而展现出其抗克氏锥虫的能力。

(6S)-CP-470711（Compound 8）作为一种山梨醇脱氢酶（sorbitol dehydrogenase, SDH）抑制剂，对人类及大鼠SDH的抑制活性表现出来，其IC50值分别为19 nM和27 nM。此外，(6S)-CP-470711能有效改善由Streptozotocin引起的大鼠糖尿病症状。

DNA crosslinker 6 (compound 1) 作为一种抗动质体化学物质，展现了与AT-DNA高效结合的特性，并且能有效阻断AT-hook 1与DNA的结合，其IC50值仅为0.03 µM。此化合物还显示出对T. brucei的显著抗原虫活性，其EC50达到0.83 µM。

Terallethrin, a pesticide, controls flying insects including houseflies, mosquitoes, and wasps.

Trimetharba is a kind of insecticide.

TDR32570 is an antimalarial agent.