Antifungal

KK14(R) 是一种合成肽KK14的衍生物，被证实具有抗真菌特性。对于Fusarium culmorum、Penicillium expansum和Aspergillus niger，其最小抑菌浓度(MIC)分别为6.25 μg/mL、12.5 μg/mL和12.5 μg/mL。此外，KK14(R) 表现出优异的热稳定性和pH稳定性。然而，它对Caco-2和RAW264.7细胞展现出一定的细胞毒性。

Pervicoside B is a triterpene glycoside.

Reductiomycin 是一种抗生素，能够抑制革兰氏阳性菌和真菌，并具有抗肿瘤活性。

Purpuride 是一种天然化合物，可作为天然产物对照品，其 CAS 号为 41411-07-8。

TOLPROCARB是一种抗卵菌类的杀菌剂，通过抑制黑色素生物合成途径中的多酮合酶（polyketide synthase）来发挥作用。

AR ligand-30 作为PROTACBavdegalutamide的靶标蛋白配体，在前列腺癌的研究中发挥关键作用。

Pyraoxystrobin 属于 QoI 类杀菌剂，针对稻瘟病菌 (M. oryzae) 分离株，展示出 0.0094 μg/mL 的 EC50。该化合物主要应用于探究水稻田稻瘟病菌。

Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite.

Brassilexin is a cyclobrassinin hydrolase inhibitor, a unique enzyme from the fungal pathogen Alternaria brassicicola.

Alteconazole is an antifungal drug.

Melianone exhibits antiviral activity (EC50s: 3-11μM) against three important human pathogens, belonging to the Flaviviridae family, West Nile virus, Dengue virus, and Yellow Fever virus.

NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related t

RK 286D is an indolocarbazole antibiotic.

Enniatin F 是一种天然化合物，可作为天然产物对照品，其 CAS 号为 144446-20-8。

Eremofortin B是倍半萜类化合物，由Penicillium roqueforti PR毒素（PRT）合成。

4-Methyl-β-naphthoflavone 是真菌中 Naphthoflavone 的代谢产物。Naphthoflavone 是 CYP-450 的激活剂或抑制剂。

Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) 作为几丁质酶 (chitinase) 的抑制剂，它能抑制 Saccharomyces cerevisiae 的细胞分裂，但对其生长不产生影响。此外，Cyclo(Arg-Pro) 也阻止 Candida albicans 从酵母形态向丝状形态的转变。

N-(3-(Dimethylamino)propyl)tetradecanamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66531，CAS号为 45267-19-4。

deacetylsclerotiorin is a new chloroazaphilones produced by the fungus Bartalinia robillardoides strain LF550.

Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu

D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infection. |1. Lazzarini, C., Haranahalli, K., Rieger, R., et al. Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids. Antimicrob. Agents Chemother. 62(5), e00156-00118 (2018).

Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-dependently increases the mortality of adult C. chinensis weevils up to 100% and has mitogenic activity against T. telarius when sprayed onto plants with an LC50 value of 9.2 μg/ml. It reduces IL-1β- and cAMP-induced secretion of phospholipase A2 (PLA2) from rat mesangial cells (IC50s = 43 and 33 nM, respectively). Tetranactin (50 ng/ml) suppresses the proliferation of human T lymphocytes induced by allogeneic cells and IL-2 and supresses the generation of cytotoxic T lymphocytes in mixed lymphocyte cultures. In vivo, tetranactin (10 mg/animal per day) completely inhibits the formation of experimental autoimmune uveoretinitis (EAU) in rats.

Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.

Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL.

Pneumocandin C0 作为Pneumocandin B0的异构体，由Glarea lozoyensis丝状真菌在高残留果糖浓度条件下的发酵过程中发现，显示出了抗真菌活性。

Destomycin A 是一种具备多重生物活性的氨基糖苷类抗生素，能有效对抗革兰氏阳性菌及革兰氏阴性菌，同时具有抗真菌和驱虫的特性。此外，Destomycin A 可抑制 Escherichia coli 细胞中的多肽合成，并能激活动物组织内的腺苷酸环化酶。

Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It also inhibits proliferation in a panel of additional cancer cell lines (IC50s = <0.01 μM).

Frenolicin B 是一种抗生素。

Cyclamidomycin is an antibiotic. It also functions as an inhibitor of nucleoside diphosphokinase of Escherichia coli.

Polyoxin D (zinc) (Polyoxorim (zinc)) ，多抗霉素类抗生素杀真菌剂，是几丁质合成酶 (chitin synthetase) 的有效抑制剂。

Isolubimin是一种源自Datura stramonium果实的倍半萜类植物抗菌素，具有显著的抗菌活性。Isolubimin被认为在研究由真菌感染导致的植物病害方面具有潜在应用价值。

Cyclobutrifluram 是一种琥珀酸脱氢酶抑制剂 (SDHI)，对F. fujikuroi的EC50平均值为0.025 μg/mL。该化合物显示出极佳的抑菌活性，有效地抑制了敏感型F. fujikuroi菌丝的生长。然而，它可能诱导F. fujikuroi产生抗性，特别是在发生FfSdhB H248L/Y以及FfSdhC2 G80R或A83V氨基酸替换时。Cyclobutrifluram 可用于水稻恶苗病 (RBD) 的研究。

Heveadride 是一种真菌代谢产物和抗菌antifungal激动剂，对丝状真菌及部分人类致病酵母具有活性。Heveadride 可以下调人类慢性白血病细胞中TNFα诱导的NF-κB活性，IC50值为82.7 μM。

Bromomonilicin 是一种选择性真菌 (fungal) 细胞膜抑制剂，其通过破坏真菌细胞膜的完整性发挥抗真菌作用。Bromomonilicin 在植物病原真菌感染（如Monilinia fructicola引起的褐腐病）以及浅表性真菌病（如皮肤癣菌感染）的研究中显示出潜力。

Curvulol 是一种聚酮结构的抗菌剂 (antimicrobial agent)，可从红豆杉 (Taxus baccata) (Chaetosphaeronema achilleae) 中分离。Curvulol 对 L929 和 KB-3-1 细胞表现出明显的细胞毒性，且有效抑制 Staphylococcus aureus 生物膜形成，MIC 为 64 μg/mL。

Voriconazole-d3 是 Voriconazole 的氘代化合物。Voriconazole 的 CAS 号为 137234-62-9。Voriconazole 是一种三唑类抗真菌剂，可抑制真菌麦角甾醇的生物合成。它特异性抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用