Antifungal

6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity of 6-substituted indoles. J. Antibiot. (Tokyo) 55(11), 1009-1012 (2002).|2. Nkunya, M.H., Makangara, J.J., and Jonker, S.A. Prenylindoles from Tanzanian Monodora and Isolona species. Nat. Prod. Res. 18(3), 253-258 (2004).

Tenellin is a fungal metabolite that inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in erythrocytes. Tenellin is cytotoxic to Sf9 and Sf21 insect cells.

4-Oxo-5-phenylpentanoic aci 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125056，CAS号为 3183-15-1。

Cyproconazole 是一种三唑类杀菌剂，在农业上用于保护作物免受多种真菌病原体的侵害。

Faltan (Folpet) 是一种广泛使用的二甲酰亚胺类杀菌剂，可诱发小鼠胃肠道肿瘤，主要发生在十二指肠，对人支气管上皮细胞也有细胞毒作用。

Monensin sodium salt (Standard) 是 Monensin sodium salt 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Monensin sodium salt (Monensin A sodium salt) 是由肉桂链霉菌 分泌的抗生素。它是一种介导Na+/H+交换的离子载体。它引起细胞多泡体 (MVBs) 增大并调节外泌体的分泌。

Citrinin (Standard) is the standard substance of Citrinin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Citrinin is a mycotoxin that causes contamination in the food and is associated with different toxic effects. Citrinin also possesses a broad spectrum of bioactivities, including antifungal, antibacterial, and potential anticancer and neuroprotective effects in vitro.

Prochloraz manganese (Standard) 是 Prochloraz manganese 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Prochloraz manganese为用于农业工业的抗真菌剂。

Procymidone (Standard) 是 Procymidone 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Procymidone是一种广谱杀菌剂，通过抑制真菌甘油三酯合成干扰菌丝生长，主要用于灰霉和菌核病，还可以作为竞争性的androgen receptor（AR）拮抗剂，能够干扰雄性大鼠的性别分化。

Ofurace (Standard) is the standard substance of Ofurace, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ofurace is a fungicide.

Propoxur (Standard) 是 Propoxur 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂，用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。

Mepronil (Standard) is the standard substance of Mepronil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Mepronil is a compound of pesticide.

Flusilazole (Standard) 是 Flusilazole 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Flusilazole (DPX6573) 是一种具有广谱抗真菌作用的有机硅杀菌剂。 Flusilazole 可用于控制多种蔬菜和水果的真菌感染。

Fludioxonil (Standard) 是 Fludioxonil 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Fludioxonil (CGA 173506) 是一种苯基吡咯类杀菌剂，可抑制草莓和黑莓作物中灰霉病菌的生长。

Benalaxyl (Standard) 是 Benalaxyl 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Benalaxyl (M-9834) 是一种农业化学品。它用作杀菌剂。

Benodanil (Standard) 是 Benodanil 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Benodanil (Calirus) 是一种杀菌剂。

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite initially derived from Penicillium, exhibiting antibacterial (MICs = 125-1000 µg/ml) and antifungal activities (MICs = 8-64 µg/ml). It also demonstrates antioxidant properties by reducing the production of hydroxy radicals, as evidenced in an electron spin resonance (ESR) spectroscopy assay (IC50 = 1.8 µM). Additionally, Cyclo(L-Leu-L-Trp) has been identified as a bitter compound capable of quickly crossing rat taste cell membranes ex vivo at a 1 mM concentration. Furthermore, it acts as a melatonin receptor agonist in X. laevis melanophores, suppressing cAMP accumulation at a 20 µM concentration, with this effect being negated by the melatonin receptor antagonist luzindole.

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

α-Guaiene, a sesquiterpene identified in P. cablin, showcases its presence within this species.

Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.

Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。

Flucytosine (NSC 103805) 是抗真菌化合物。

Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline))是一种存在于Phellinus igniarius 中的天然产物。

Somantadine 具有抗病毒活性，可用于预防和治疗冠状病毒相关疾病的研究。

Imazalil sulfate 是一种含有咪唑基团的杀菌剂，广泛用于防治植物真菌病害。

Antibacterial agent 131 是一种具有抗菌作用的化合物。

Econazole nitrate (NSC-243115) 是一种有抗菌活性的咪唑类抗真菌药物。

Asperphenamate 是 Aspergillus flatiipes 的真菌代谢产物。 T47D 细胞、MDA-MB-231 细胞和 HL-60 细胞的 IC50 分别为 92.3 μM、96.5 μM 和 97.9 μM。 Asperphenamate 具有抗癌作用。

(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。

Flutriafol 是一种三唑类广谱杀菌试剂。

Acriflavine Hydrochloride (Acriflavine HCl) 是一种 HIF-1α 抑制剂。它通过靶向 HIF-1α 介导的途径并在体外和体内降低 PGK1、VEGF 和 HIF-1α 的水平发挥作用。

Spiroxamine 是一种叔胺类杀菌剂，是 δ14 还原酶和 δ8→δ7 异构酶的抑制剂。 Spiroxamine 抑制从葡萄藤中分离出的 N. parvum、B. dothidea、D. seriata 和 L. theobromae 的生长。

Potassium sorbate (Sorbic acid potassium salt) 是一种高效安全无毒的食品防腐剂，可有效抑制大多数霉菌，酵母和某些细菌。

Dipyrithione 似乎具有新的细胞毒性和强大的广谱抗肿瘤活性。

Deacylketoconazole (Deacyl ketoconazole) 是一种酮康唑衍生物，也是一种抗真菌剂。 脱酰基酮康唑对恶性疟原虫的活性是酮康唑的 15 至 50 倍。

Phenylethyl isothiocyanate (JC5411) 是一种 HDAC 抑制剂。它有可能用于治疗良性前列腺肥大。