Others

BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.

Disoxaril (BRN 3626820, WIN 51711) is an anti-picornavirus agent that inhibits enterovirus replication by binding to a hydrophobic bag within the VP1 coat protein, thereby stabilizing virions and preventing their uncoating. When used in combination with A

PAR 4 (1-6) 可用于生命科学领域的相关研究。其产品编号为 T36293，CAS号为 225779-44-2。

Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/ml, respectively.

X 14547-A is a biochemical product.

6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity of 6-substituted indoles. J. Antibiot. (Tokyo) 55(11), 1009-1012 (2002).|2. Nkunya, M.H., Makangara, J.J., and Jonker, S.A. Prenylindoles from Tanzanian Monodora and Isolona species. Nat. Prod. Res. 18(3), 253-258 (2004).

(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R)-Carvedilol glucuronide is formed via glucuronidation of (R)-carvedilol by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT2B4. (S)-Carvedilol glucuronide is formed via glucuronidation of (S)-carvedilol by UGT2B4 and UGT2B7.

bpV(pic) (potassium hydrate) 可用于生命科学领域的相关研究。其产品编号为 T35630，CAS号为 148556-27-8。

Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.

Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml.

MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC50 value of about 0.7 μM. Additionally, MY33-3 has been shown to effectively decrease ethanol consumption and alleviate neuroinflammation and cognitive dysfunction induced by Sevoflurane.

Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.

Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 50 = 54 nM) and inhibits EGFR autophosphorylation induced by EGF in tumor cells. Additionally, Gefitinib induces autophagy and exhibits antitumor activity.

N-Butylthiophosphoric triamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65336，CAS号为 94317-64-3。

Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂，对 α4β2 亚型有高度选择性(Ki= 26 nM)，比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。

Risperidone E-oxime is an impurity of Risperidone, a serotonin 5-HT2 receptor blocker, P-glycoprotein inhibitor, and potent dopamine D2 receptor antagonist (Kis of 4.8 and 5.9 nM for 5-HT2A and dopamine D2 receptors, respectively).

Dibenzylideneacetone is a synthetic curcumin analog. It leads to apoptotic cell death in Leishmania donovani.

Aspirin DL-lysine is a non-steroidal anti-inflammatory drug. It also may inhibit cancer growth. Aspirin DL-lysine is a water-soluble, injectable aspirin derivative.

Fmoc-HoCys(ACM)-OH 是一种氨基酸衍生物，在生命科学相关研究中具有广泛的应用。

1,2-Diarachidoyl-sn-glycero-3-PC 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67070，CAS号为 61596-53-0。

Galloflavin Potassium is an inhibitor of lactate dehydrogenase.

Flutimide是一种针对流感病毒核酸内切酶的选择性抑制剂，具有3 μM的IC50值，表现出细胞培养中的抗病毒活性，适用于流感等急性传染性呼吸道疾病的研究。

Tenellin is a fungal metabolite that inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in erythrocytes. Tenellin is cytotoxic to Sf9 and Sf21 insect cells.

KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27.

Plipastatin A1是一种在B. cereus中发现的脂肽类化合物，具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2（PLA2）、PLC和PLD（IC50分别为2.9、1.3和1.4 µM）。Plipastatin A1（100 µg/ml）能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内，Plipastatin A1（0.1 mg/动物）能抑制小鼠的迟发型超敏反应。

1,2-Dihexanoyl-sn-Glycero-3-Phosphocholine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TF0018，CAS号为 34506-67-7。

2,3,4,6-Tetra-O-benzyl-D-glucopyranose 是一种用于生命科学研究的生物材料或有机化合物的生化试剂。

cis-VZ 185 is a negative control for VZ 185.

4-Oxo-5-phenylpentanoic aci 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125056，CAS号为 3183-15-1。

Ono-3805 is an inhibitor of nonsteroidal 5 alpha-reductase.

D-Cystine, the D-enantiomer of L-Cystine, functions as an inhibitor of L-aspartate-β-semialdehyde dehydrogenase (ASADH) derived from Escherichia coli.

N-Acetylthyroxine is a kind of Thyroxine analogue for the treatment of diagnosing and treating diabetes.

Dibenzo[b,e]oxepin-11(6H)-one 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65977，CAS号为 4504-87-4。

(2S,3S)-2-((2S,3S)-2-(((Benzyloxy)carbonyl)amino)-3-methylpentanamido)-3-methylpentanoic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65505，CAS号为 42538-01-2。

1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66423，CAS号为 112811-57-1。

Ac-Lys-OMe.HCl 是一种氨基酸衍生物，在生命科学相关研究中具有广泛的应用。