Antibacterial

Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。

IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.

Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is a defensin mimetic antibiotic compound, exhibiting potent anti-infective antimicrobial activity against a range of bacteria. It demonstrates MIC90 values of 1 μg/mL and 8 μg/mL against the Gram-positive bacteria Streptococcus pneumoniae and Streptococcus viridans, respectively. Additionally, it has a MIC90 value of 8 μg/mL for the Gram-negative bacteria Haemophilus influenzae and a MIC90 value of 4 μg/mL for Pseudomonas aeruginosa.

Trovafloxacin 是广谱喹诺酮类抗生素，对革兰氏阳性，革兰氏阴性和厌氧菌有活性。它可阻断 DNA 促旋酶 和拓扑异构酶 IV 的活性。它也是口服活性的 Pannexin 1通道选择性抑制剂，对 PANX1内向电流的 IC50为 4 μM。

Brain Derived BasicFibroblast Growth Factor(1-24) (FGF basic 1-24) 是一种合成肽，表现出抗细菌和抗HBV 的活性。Brain Derived BasicFibroblast Growth Factor(1-24) 可用于感染性疾病和免疫性疾病的研究。

LF11 displays antimicrobial activity.

Beta-Solamarine has antibacterial activity.

Cetraxate (free base) is a broad spectrum peptide hydrolase inhibitor.

Kapurimycin A3 is an antitumor antibiotics.

Urechistachykinin II (Uru-TK II) is an invertebrate rapid kinin-related peptide (TRPs) isolated from carotenoid worms.

Micronomicin sulfate (Gentamicin C2b sulfate) 是一种氨基糖苷类抗生素，具有抗菌活性，抑制甲型流感病毒的神经氨酸酶 N1。

Maslinic acid (Crategolic acid) 是一种 DNA 聚合酶 B 抑制剂，抑制 NF-κB p65的 DNA 结合活性并消除 IκB-α磷酸化。

Aurein 3.1为一种具备针对革兰氏阳性菌的抗菌活性的抗生素抗菌肽，MIC值显示对M. luteus、S. aureus、S. epidermis、S. mutans及B. subtilis的有效浓度分别为80, 50, 50, 50, 50 μM。

Cecropin P1, porcine acetate 是一种在 Hyalophora cecropia 和猪肠道中发现的抗菌肽。

Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.

Sulfaclozine sodium is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases.

Physcion (Physcione) 是一种从中药大黄中分离的蒽醌，作为 6-磷酸葡萄糖酸脱氢酶的抑制剂，IC50和 Kd 值分别为 38.5 μM 和 26.0 μM。它具有通便、保肝、抗炎、抗菌、抗增殖、抗肿瘤作用。

Cefixime (FR-17027) 是一种头孢菌素类抗生素, 可研究一些细菌感染。

Thanatin是一种具有抗真菌和部分Gram-positive细菌活性的抗菌肽。

Lanopepden mesylate 是一种肽去甲酰酶抑制剂，可抑制金黄色葡萄球菌。

Diazolidinyl urea (Germall II) 是一种甲醛释放防腐剂，用于化妆品和个人护理产品。它对大多数污染微生物，特别是假单胞菌都有效。

(rac)-Xeruborbactam ammonium 是一种β-内酰胺酶抑制剂，可用于研究细菌感染。

Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.

Acetylazide is a synthetic broad-spectrum bacteriostatic antibiotic.

Miconazole nitrate (R18134 nitrate) 是咪唑类可抗菌的抗真菌剂。

Spermine (Neuridine) 作为一个直接的自由基清除剂，具有抗病毒作用，能够保护 DNA 免受自由基的攻击。

Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM).

Piperlongumine (Piplartine) 属于生物碱类天然产物，具有抗肿瘤、抗炎、抗氧化、抗血管生成等生物活性。Piperlongumine 可以增强 ROS 水平，诱导肿瘤细胞凋亡。

Copper Sulfate Pentahydrate具有多种抑菌活性，对金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌，白色念珠菌等具有抑制活性。

The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.

(R)-ZG197为一种对金黄色葡萄球菌酪蛋白溶解蛋白酶P (SaClpP) 具有高选择性的激活剂，EC50值为1.5 μM。此外，(R)-ZG197还能激活人类ClpP (HsClpP)，其EC50为31.4 μM。

GT-1 (LCB10-0200) is a siderophore-linked cephalosporin compound that effectively combats clinical isolates of various bacterial species, including P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.

Puromycin dihydrochloride (CL13900 dihydrochloride) 属于肉桂酰胺腺苷抗生素，是一种蛋白质合成的抑制剂。Puromycin dihydrochloride 通过与 RNA 结合来抑制蛋白质合成，具有抗肿瘤和抗锥虫活性。

BB-78485 是一种有效的 LpxC 金属酶小分子抑制剂，具有抗菌作用。 BB-78485 对 LpxC 的 IC50 值为 160 nM。 BB-78485 可用于研究革兰氏阴性菌感染。