Antifection

Azadirachtin B (Deacetylazadirachtinol) 是可从 Azadirachta 种子中分离的萜类化合物，具有杀虫、抗癌、抗炎、抗肿瘤和抗病毒活性，可用于研究病毒感染。Azadirachtin B 具有成骨细胞增殖、分化和矿化能力。

Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.

Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against Staphylococcus aureus.

14-Deoxycoleon U has anti-termitic activity, it is highly active against both wood-decay fungi. 14-Deoxycoleon U shows antibacterial activity against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and

Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as ini

4-Hydroxyalternariol 9-methyl ether displays promising antioxidant effects. It also shows antibacterial activity against several tested bacterial pathogens with minimum inhibitory concentration values in the range of 86.7-364.7 uM.

Methyl-6-acetoxy angolensate may have antimalarial activity.

Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectively.

2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Jatrophane 2 also demonstrates the mo

8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone may have antifungal activity against phytopathogenic and human pathogenic fungi.

Jatrophane 4 (2R*,3R*,4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,9,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxyjatropha-6(17),11E-diene) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera), with an EC50 value of 0.36 ug/cm2.

ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than 10 microg /mL for most pathogens).

5-Hydroxy-1-methoxyxanthone, 1,5-dihydroxyxanthone and 6-deoxyjacareubin are all antifungal against Cladosporium cucumerinum, while they show differing degrees of inhibition of monoamine oxidase A and B.

Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows considerable inhibition on the production of nitric oxide and reduces the production of interleukin-6 in dose-dependent manner in RAW 264.7 cells.

1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>

Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant

The binding affinities of ganoderic acid DM andGanoderic acid ζ (ΔGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.

Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against Ichthyophthirius multifiliis.

Nigracin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4656，CAS号为 18463-25-7。

Epikatonic acid shows less active against T. (S.) cruzi trypanosome.

A mixture of (E)-octadecyl p-coumarate and (Z)-octadecyl p-coumarate has antifungal activity , it shows the dose dependent inhibition of the spore germination of Alternaria alternata and A. porri.

Seneganolide has insect antifeeding activity. Seneganolide A has antifungal activity.

Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of

Aphadilactone B shows significant antimalarial activity with the IC50 value of 1350 ± 150 nM.

3',4',5',3,5,6,7-Heptamethoxyflavone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2864，CAS号为 17245-30-6。

Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI

6-Methyl-5,6-dihydropyran-2-on is bactericidal,and antiprotozoal agents.

Antimicrobial agent.

Macrocarpal J has anti-bacterial activity, it also has anti-glucosyltransferase activity.

Scopoline, tropinol, ecgonine, and granatoline derivatives are therapeutic agents of the pyrrole and pyridine group. Scopoline has fungitoxic effects, it is inhibitory to Sclerotinia at similar doses to scopoletin; as scopolin is known to be less phytotox

20-Hydroxylucidenic acid E2 是一种在 Ganoderma ludicum 中发现的三萜类化合物，对 TPA 诱导的炎症具有显著的抑制作用。此外，20-Hydroxylucidenic acid E2 能抑制 TPA 诱导的 EBV 早期抗原表达，IC50 为 290 mol ratio/32 pmol TPA（即当此化合物的摩尔浓度为 TPA (32 pmol) 的 290 倍时，能抑制 50% 的 EBV 早期抗原表达）。20-Hydroxylucidenic acid E2 可用于抗炎和抗癌研究。

EBVEBNA3B (416-424) 是源自EBVEBNA3B蛋白的一种HLA-A11限制性抗原肽。

Azadirachtin 是一种有前途的植物源杀虫剂，能够诱导昆虫 Sf9、SL-1 和 BTI-Tn-5B1-4 细胞凋亡。它广泛用于害虫防治。

Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。

Platyphyllenone 存在于 Alnus nepalensis 中并显示出抗丝虫活性。

Neochamaejasmin B 是一种提取自Stellera chamaejasme L.的双黄酮化合物。它在 C-2/C-3 和 C-2″/C-3″ 位置具有顺反几何结构。