Others

MK-4965 is a new type of non-nucleoside reverse transcriptase inhibitor with antiviral activity.

Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 μg/larva).

DSPE-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.

Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.

RORγt inverse agonist 30 (Compound 1) 是一种有效的 RORγt 反向激动剂 (IC50: 46 nM)。靶向核受体 RORγt 能够有效治疗自身免疫性疾病。

Lipid peroxidation inhibitor 1 is an inhibitor of lipid peroxidation (IC50: 0.07 μM).

9-Decenoic acid（9-癸烯酸）是一种含有10个碳原子的单不饱和脂肪酸，可用于有机合成和生化实验。

Thioquinapiperifil is a type of phosphodiesterase-5 (PDE-5) inhibitor found in dietary supplements.

Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor.

DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a Nucleoside Phosphoramidite.

(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种选择性的β1 肾上腺素能受体拮抗剂（IC50= 0.8 nM）。Nebivolol 显示血管舒张活性。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2/NADPH 氧化酶上调和脂质过氧化。

CTP Synthetase-IN-1 Ammonium salt 是一种具有口服活性和高效性的胞苷 5'-三磷酸合成酶 (CTPS) 抑制剂，具有潜在的抗菌抗炎抗肿瘤活性，可用于研究 SARS-CoV-2病毒感染。

Theviridoside is a natural product found in the leaves of Cerbera odollam.

N-Phenylacrylamide 通过荧光转酰胺法抑制人重组 TGM2。

Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 μg/ml, respectively).1

ICRF-193 is a DNA topoisomerase II inhibitor.

BLK degrader 1 是一种选择性 B 淋巴样酪氨酸激酶 (BLK) 降解剂，具有抗癌活性，可用于研究癌症。

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).

NSC-668036 is an inhibitor of Dishevelled (Dvl) protein, a key protein in wnt signaling.

17α-Hydroxyprogesterone acetate 具有孕激素活性和抗炎活性。

2,5-Diphenylpyridine与铂联用时对多种肿瘤细胞系具有抗癌活性，广泛应用于生物化学实验和药物合成研究。

Nucleoside Derivatives - Fluoro-modified nucleosides; 3'-Modified nucleosides; Xylo-nucleosides

DENV-IN-9 是一种DENV2抑制剂，EC50为 0.88 μM。

Light Green SF Yellowish (Acid Green 5) 是一种碱性染色剂，可用于动物组织染色，可用于植物组织学中作细胞质和纤维染色。

SCH 42495 is an orally active neutral metalloendopeptidase inhibitor. SCH 42495 is the orally active ethyl ester prodrug of SCH 42354.

hDDAH-1-IN-2 is an orally active human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) inhibitor.

Cimifugin 4'-O-beta-D-glucopyranoside is a natural product

Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.

Cefazolin sodium pentahydrate 是一代头孢菌素类抗生素，可用于多种细菌感染的研究。Cefazolin sodium pentahydrate 具有抗炎作用，可以减轻术后认知功能障碍 (POCD)。

Carnostatine hydrochloride (SAN9812 hydrochloride) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的Ki 值为 11 nM。Carnostatine hydrochloride 可用于治疗糖尿病性肾病 (DN) 。

HEPPSO是一种两性离子缓冲剂，pH范围为7.1~8.5，对铜离子copper(II)具有强效的结合能力，广泛用于生物化学实验。

Atomoxetine hydrochloride (Standard) 是一种可用于分析的标准物质，通常用作 Atomoxetine hydrochloride 的研究和分析中参考的标准样品。Atomoxetine hydrochloride (LY 139603) 是苯氧基-3-丙胺衍生物和选择性非兴奋剂，是去甲肾上腺素再摄取抑制剂，具有认知增强活性。 与人 NET，SERT 和 DAT 的放射性配体结合的 Ki 分别为5，77和1451 nM。

1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs[1].

CMB-087229为一种针对突变SOD1蛋白的聚集阻断剂，具有IC50值为67 nM，主要用于肌萎缩侧索硬化症的研究。

2'-C-Methyl nucleoside; 2/6/8-modified nucleoside