Neprilysin

MDL-100240 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin with a balanced activity. MDL 100240 shows an impressive effectiveness both in preventing and in regressing hypertension-induced vascular remodeling and cardiac hypertrop

Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation.

Enkephalin-met, des-tyr(1)- ccauses retrograde amnesia in rats.

Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril.

Risotilide is a voltage-dependent potassium channel inhibitor. It can prolong cardiac action potentials and refractory periods.

LHW090-A7 是一种中性肽链内切酶 (NEP) 抑制剂，是一种负责脑啡肽代谢失活的酶。

SCH 42495 is an orally active neutral metalloendopeptidase inhibitor. SCH 42495 is the orally active ethyl ester prodrug of SCH 42354.

Sch 32615 is an enkephalinase inhibitor with inhibitory action on D-1 and D-2 dopamine receptor-mediated behaviors.

Kelatorphan is an enkephalin degrading enzyme full inhibitor.

JA2作为金属内切肽酶24.15的抑制剂，能够提升大鼠对缓激肽引发的降血压反应。

Benproperine is a bioactive molecule with antineoplastic properties.

SCH-39370 is a potent and specific neutral metalloendopeptidase (NEP) inhibitor.

(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active inhibitor of neutral metalloendopeptidase (NEP), with antihypertensive effect.

SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.

Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM).

Met-Arg-Phe-Ala为一种肽类化合物，同时作为脑啡肽生成内肽酶（EGE）的有效竞争性抑制剂，应用于神经系统疾病的研究。

NEP-IN-2 is an inhibitor of neutral endopeptidase. It also is used in the research of proliferation in atherosclerosis, restenosis.

Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM。

Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。

Phosphoramidon is a membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor and thermolysin inhibitor, which is obtained from culture filtrate of Streptomyces tanashiensis.

AD015 是血管紧张素转换酶（ACE）和脑啡肽酶（NEP）的双重抑制剂。它对 NEP、nACE 和 cACE 的抑制作用分别为 0.009、0.019 和 0.0008 μM 的 IC50。

NEP-IN-1 是中性肽链内切酶 (NEP) 的抑制剂 (IC50 = 2 nM)。

Omapatrilat是一种口服有效的ACE(血管紧张素转换酶)和NEP(neprilysin)双重抑制剂，Ki值分别为0.64和0.45 nM，能够抑制大鼠诱发性低血压。

Aladotril is an inhibitor of neutral endopeptidase. Its prodrug is aladotrilat.

Dexecadotril is a powerful and selective neprilysin inhibitor. It behaves as a prodrug of the enantiomer of thiorphan.

Phenylalanylalanine（H-Phe-Ala-OH）是由苯丙氨酸和丙氨酸融合形成的二肽。它在蛋白质的不完全消化或分解过程中形成[1]。

SQ28603 is a potent and selective neutral endopeptidase 3.4.24.11 (NEP) inhibitor.

Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性，Ki 分别为 4500 和 6.1 nM。

Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。

Sacubitril sodium (沙库必曲钠盐,AHU377)是一种有效的NEP抑制剂，IC50=5 nM，可治疗心力衰竭或者作为降压药联用。

Candoxatril (UK 79300) 是具有口服活性的中性肽链内切酶 (NEP，EC 3.4.24.11) 抑制剂，可改善接受血管紧张素转换酶抑制的慢性心力衰竭患者的运动能力。

Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。

Sch 34826 is a potent, selective neutral endopeptidase inhibitor.

Cgs 25155 is an orally active inhibitor of NEP 24.11.

Mixanpril is an RB 105 lipophilic prodrug.

AHU-377-d4 是 AHU-377 的氘代化合物。