Others

Y-9738 is an agent of hypolipidemic.

MeOIstPyrd是抗皮肤癌活性分子，其作用机制包括激活线粒体内在的细胞凋亡通路，从而抑制细胞的增殖、迁移及球体形成，并能诱导DNA损伤。此外，MeOIstPyrd还能激活p53蛋白、延长其半衰期，并通过ser15位点的磷酸化增强p53的稳定性。它通过与MDM2在p53子口袋内的结合位点互作，阻断p53与MDM2的相互作用。

1-(3’-O-[4,4’-dimethoxytrityl]-alpha-L-threofuranosyl)uridine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU1627，CAS号为 325683-90-7。

Utatrectinib (AZD-7451) 是一种有效的、选择性的和具有口服活性的Trk 抑制剂。Utatrectinib 可阻断TrkC 激活和相关的致瘤行为。

Cinolazepam is a benzodiazepine derivative drug.It has a powerful sedative effect, so it is mainly used as a hypnotic.

1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol 是一种三酰基甘油，其结构特征在于 sn-1 和 sn-2 位置上连接有棕榈酸，在 sn-3 位置上连接有辛酸。棕榈酸，一种广泛存在于动植物体中的长链饱和脂肪酸，已知能够在小鼠颗粒细胞中诱导葡萄糖调节蛋白 78 (GRP78) 与 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。辛酸，作为一种具有微弱腐臭味的油性液体，不仅应用于酯类香料与染料的制备中，还被认为是一种有效的震颤抑制剂。

Palmitic acid calcium，一种长链饱和脂肪酸，广泛存在于动物和植物中。它能在小鼠颗粒细胞诱导葡萄糖调节蛋白78 (GRP78) 和CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达，可用于建立细胞脂肪变性模型。

2-O-Ethyl PAF C-16 作为 PAF 的一种同系物，充当 PAF 受体（Platelet-activating Factor Receptor (PAFR)）的竞争型配体。它能够阻断 PAF 拮抗剂 WEB 2086 与 PAF 受体的结合，表现出 21 nM 的 IC50 值。

15-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), is recognized for its involvement in metabolic regulation. This compound comprises stearic acid esterified to 5-hydroxy stearic acid and is notably influenced by dietary changes, such as fasting and high-fat consumption, with a link to insulin sensitivity. SAHSA levels are specifically found to be moderately increased in the serum of AG4OX mice, which are characterized by their glucose tolerance through the overexpression of the Glut4 glucose transporter in adipose tissue. Given the established functions of FAHFAs in enhancing glucose tolerance, prompting insulin secretion, and exerting anti-inflammatory properties, 5-SAHSA emerges as a potential bioactive lipid implicated in the management of metabolic syndrome and inflammation.

4-Nitrophenyl palmitate serves as a colorimetric substrate for lipase and esterase, enabling the quantification of enzyme activity through the release and colorimetric detection of 4-nitrophenol at 410 nm following enzymatic hydrolysis. This compound facilitates the characterization of enzyme activity across diverse bacterial and mammalian sources, including Burkholderia and porcine pancreatic lipases.

Rhodamine 101 inner salt是一种明亮的荧光染料，激发和发射最大值分别为565和595 nm。它可用于各种生物学应用，如荧光显微镜、流式细胞术、荧光相关光谱和ELISA。

10(E),12(Z)-Conjugated linoleic acid methyl ester serves as a standard for quantifying 10(E),12(Z)-conjugated linoleic acid in L. plantarum culture samples. [Matreya, LLC. Catalog No. 1254]

JWH 387, a potent analgesic cannabimimetic belonging to the naphthoylindole family, serves as a strong cannabinoid (CB) agonist targeting both central CB1 and peripheral CB2 receptors with Ki values of 1.2 and 1.1 nM, respectively. This compound is designed for research and forensic applications.

1,3-Dieicosenoyl glycerol is a diacylglycerol featuring 11(Z)-eicosenoic acid at both the sn-1 and sn-3 positions.

"20α-Dihydro Prednisolone, a prednisolone metabolite, is detected in cattle urine post-adrenocorticotropic hormone (ACTH) administration but absent in both naturally stressed and non-stressed cattle."

Anhydroleucovorin是维生素B9（叶酸）的主要生物活性形式，在人体中有多种重要细胞功能，包括DNA合成、修复和甲基化，以及关键神经递质的产生。甲基四氢叶酸在再甲基化途径中通过将氨基酸同型半胱氨酸转化为蛋氨酸发挥关键代谢作用，是体循环中发现的主要叶酸形式，并被运输至组织供生理利用。

Prostaglandin H2 (PGH2), initially isolated from the incubation of arachidonic acid with ovine seminal vesicle microsomes, acts as a potent vasoconstrictor. It serves as the precursor for all 2-series prostaglandins (PGs) and thromboxanes (TXs). Moreover, as a TP receptor agonist, PGH2 irreversibly aggregates human platelets at concentrations of 50-100 ng/ml.

1,2-Dilauroyl-sn-glycero-3-phospho-(2R)-glycerol is a type of phosphoglycerol characterized by the presence of lauric acid at the sn-1 and sn-2 positions. [Matreya, LLC. Catalog No. 1443]

Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC50 value of 1,330 nM. In vivo, desethoxy quetiapine at dosages of 20 and 40 mg/kg mitigates dopamine receptor agonist apomorphine-induced climbing behavior and ameliorates swimming deficits in mice, showcasing its potential modulatory effects on dopamine-mediated behaviors.

(3R,5R)-Rosuvastatin, a potential impurity detected in bulk rosuvastatin formulations, arises as a degradation product through various stresses including acid or base hydrolysis, thermal, photolytic, hydrolytic, oxidative stress, or during storage. This compound is associated with the HMG-CoA reductase inhibitor class to which rosuvastatin belongs.

rel-HDMP 28 hydrochloride (Compound 2g) 为一种哌醋甲酯类似物，具有对SERT的选择性结合能力（Ki= 105 nM）。

Fasnall, a fatty acid synthase (FASN) inhibitor, exhibits an IC50 of 3.71 μM against the human recombinant enzyme. It halts tritiated acetate incorporation into lipids (IC50= 5.84 μM), boosts ceramide levels, and triggers lipid droplet formation in BT474 HER2+ breast cancer cells. Demonstrating antiproliferative effects on various breast cancer cell lines, including non-tumorigenic MCF-10A and tumorigenic MCF-7, MDA-MB-468, BT474, and SK-BR-3, its efficacy is directly linked to FASN expression in vitro. In murine models of HER2+ breast cancer, particularly the MMTV-Neu model, Fasnall significantly reduces tumor volume and extends survival. Furthermore, it enhances the efficacy of carboplatin in vivo, bolstering the objective response rate of stable disease from 25% with carboplatin alone to 88% when paired with Fasnall.

C32 Ceramide (d18:1/32:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 34227-73-1。

3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its administration at 100 mg/kg daily curtails weight gain and body fat without diminishing food consumption or hiking energy output, whilst ameliorating glucose tolerance. Notably, 3-aminoisobutyric acid concentrations are heightened in individuals with β-ureidopropionase deficiency, a genetic flaw impairing pyrimidine degradation, affecting plasma, urine, and cerebrospinal fluid.

Advanced glycation end products (AGEs) are compounds that are produced through non-enzymatic chemical reactions when sugars bond with proteins or lipids, occurring in conditions such as diabetes, uremia, aging, and rheumatic arthritis. A specific receptor, known as RAGE, interacts with select AGEs to trigger cell signaling. Pentosidine, a prominently studied natural AGE, serves as a common biomarker for assessing AGE production. Although pentosidine levels can be determined through urine analysis, it is predominantly broken down prior to excretion.

Leukotriene B4 (LTB4)-3-aminopropylamide is an analog of LTB4 that exhibits potent and selective binding to the BLT1 receptor with Ki values of 5.1 nM at BLT1 and 1,227 nM at BLT2, indicating its high affinity for BLT1 over BLT2. This compound's effects are mediated through interactions with two receptors, BLT1 and BLT2.

ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].

FTY720, an immune modulator, down-regulates sphingosine-1-phosphate (S1P) receptors, enhances the activity of sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1, and inhibits cytosolic phospholipase A2 activity. Its efficacy relies on in vivo phosphorylation by sphingosine kinases, resulting in FTY720-phosphate which also down-regulates S1P receptors. NBD-FTY720, a fluorescently-labeled analog of FTY720, retains the hydroxy methyl side chain targeted for phosphorylation, suggesting potential phosphorylation in vivo.

GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the farnesylation of H-Ras (IC50= >30 µM). Moreover, GGTI 2133 reduces the growth, migration, and invasion of oral squamous cell carcinoma (OSSC) cells to 75, 45, and 27% of control levels, respectively. When administered intraperitoneally at 5 mg/kg per day, it prevents eosinophil infiltration into the airways in a mouse model of allergic bronchial asthma, although it does not reduce chemokine levels. Additionally, GGTI 2133 thwarts naloxone-induced contraction of ileum in rats experiencing morphine withdrawal syndrome and mitigates the severity of withdrawal symptoms in vivo (ED50= 0.076 mg/kg).

1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) 是内源性代谢物，常用于非酒精性脂肪性肝病的研究。

Trans-9-Octadecenol 是一种有机化合物，属于醇类。它具温和脂肪气味，常见于肉类和奶制品等食物中。在香精香料行业中，Trans-9-Octadecenol 被广泛用于香水、古龙水和空气清新剂等产品作为香味剂。此外，它可能对抑制炎症相关疾病和癌症有潜在用途。

Mead acid, a 20-carbon ω-9 polyunsaturated fatty acid, experiences elevated levels in human plasma under conditions of essential fatty acid deficiency. As 1,25(Z),8(Z),11(Z)-Eicosatrienoic Acid methyl ester (Mead acid methyl ester), it frequently serves as a standard for fatty acid analysis, particularly after fatty acids have been transesterified into methyl esters.

Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.

CPM 是一种马来酰亚胺衍生物，作为蓝色荧光硫醇活性染料，激发和发射最大波长为 384nm 和 470nm。

12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms.