Others

Anti-MRSA agent 1 是 MRSA 抑制剂，其 MIC 值为 0.5 μg/mL，能够有效的缓解 MRSA 抵抗作用。

DYSP-C34是一种生物相容性强且有效的超声（US）激活多功能分子机器。它提升了亲脂性/亲水性平衡，增强了超声诱导的ROS产生，并改善了细胞渗透能力，进而显著提升了对肿瘤的靶向效果及声动力疗法（SDT）介导的肿瘤缩减能力。此外，DYSP-C34还通过激活APC展示出温和的免疫原性。

L-Hexaguluronic acid, a linear polysaccharide copolymer, consists of six units of L-guluronic acid (G).

Benzyl-PEG7-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。

CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).

AG-10 (Acoramidis) 是选择性的、口服有效的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，显示出对野生型和 V1221 突变型均有效。

PEG3-C4-OBn, a polyethylene glycol (PEG)-based PROTAC linker, is utilized in crafting the PROTAC SGK3 degrader-1, a potent SKG3 degrader leveraging PROTAC technology [1][2].

Donepezil (Standard) 是一种可用于分析的标准物质，通常用作 Donepezil 的研究和分析中参考的标准样品。Donepezil (Aricept) 是一种AChE 抑制剂，对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。

PYR01为一种高效的HIV-1非核苷逆转录酶抑制剂，同时作为针对消除表达HIV-1细胞的细胞杀伤分子的靶向激活剂。

Nortrachelogenin-8'-O-beta-glucoside 是一种具有二芳基羟基丁内酯骨架的木脂素，其分离自 Trachelospermum jasminoides (Lindl.) Lem 的叶和茎。

MYLS22 是视神经萎缩 1 的选择性抑制剂。它通过影响 NFkB 活性和血管生成基因表达抑制血管生成，靶向作用于内皮细胞 OPA1 ，减少肿瘤的生长。

Nucleosides Derivatives –Halo-nucleosides; Scaffolds and Templates

Gly-PEG3-endo-BCN is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

YH16899 is a KRS-67LR interaction inhibitor by directly blocking the association between KRS and 67LR, suppressing the dynamic movement of the N-terminal extension of KRS and reducing membrane localization of KRS.

2-Diethylamino-3'-benzyloxyacetanilide 是一种有机化合物，属于乙酰苯胺类衍生物。2-Diethylamino-3'-benzyloxyacetanilide 可能具有生物活性，常用于有机合成、药物化学或生物医学研究。其亲脂性和碱性可能影响其溶解性、代谢特性及药理作用，特别是在局部麻醉剂或相关药物的开发中可能具有潜在应用。

Lipopolysaccharides（LPS）来源于大肠杆菌O55:B5，是革兰氏阴性菌外膜的重要成分，由脂质A、核心寡糖和O-特异性多糖组成，具有高免疫原性，能激活免疫细胞TLR4受体，诱导细胞迁移体分泌，并有助于维持细菌外膜完整性、抵御胆汁盐和脂类抗生素的破坏，常用于炎症模型的构建，如关节炎、慢性阻塞性肺病（COPD）、急性呼吸窘迫综合征（ARDS）、以及消化系统等疾病模型的构建。

HPK1-IN-12 是一种 HPK1 的有效抑制剂。HPK1 为造血祖细胞中克隆出来的丝氨酸/苏氨酸蛋白激酶，属于哺乳动物Ste-20相关蛋白激酶MAP4K 家族。HPK1-IN-12 具有潜力进行 HPK1 相关疾病的研究。

MUF-diNAG（4-μU-(GlcNAc)2）是一种专为几丁质酶和几丁二糖苷酶设计的荧光底物，酶促切割后释放荧光基团 4-μU。该底物在 pH 依赖条件下的激发峰位于 320 和 360 nm，发射峰在 445–455 nm 之间，可用于对几丁质降解酶活性进行灵敏而定量的生化和微生物学分析。

Cinromide (trans-3-Bromo-N-ethylcinnamamide) 是抗惊厥药，能够抑制上皮中性氨基酸转运蛋白 B0AT1 (SLC6A19)，其 IC50=0.5 μM。

17-Hydroxyneomatrine 是一种从苦参 (Sophora flavescens) 提取的化合物，有效抑制人宫颈癌Hela细胞生长，并展现抗菌、抗过敏、抗肿瘤、抗心律失常、消肿、利尿、免疫调节等多种生物活性。

Precyasterone 是一种天然产物，分离自 Cyathula capitata 干燥的根中。

Nucleoside Derivatives - Azido-nucleosides, 3'-Modified nucleosides

Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).

3-Oxo-C14-AHL (N-(3-Oxotetradecanoyl)-DL-homoserine lactone) 是由革兰氏阴性菌产生的群体感应 (QS) 信号分子，可用来提高能农作物的产量。

Tigecycline (Standard) 是一种可用于分析的标准物质，通常用作 Tigecycline 的研究和分析中参考的标准样品。Tigecycline (GAR-936) 是甘氨酰环素抗生素，对 Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对 E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。

Hydroxy-PEG7-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10.

Ac4GlcNAz(N-叠氮基乙酰葡糖胺四酰化)是一种细胞渗透性的叠氮官能化标记物，其天然单糖对应物为GlcNAc，能够通过点击化学进行后续纯化或引入荧光基团来观察糖缀合。

Lobeglitazone Sulfate（CKD-501 Sulfate） 是一种新型噻唑烷二酮,具有抗炎活性，抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症，可用于研究 2 型糖尿病 (T2DM)。

SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1.

SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a multifunctional inhibitor of SARS CoV-2 3CLpro, exhibiting antiviral, antibacterial, and antifungal activities.

Biotin-PEG2-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

C24 dihydro Ceramide (d18:0/24:0) (Standard) 是一种可用于分析的标准物质，通常用作 C24 dihydro Ceramide (d18:0/24:0) 的研究和分析中参考的标准样品。C24 dihydro Ceramide 是一种鞘脂类物质，存在于人类皮肤的角质层中。与男性皮脂相比，女性皮脂中的 C24 dihydro Ceramide 含量更高。

Vocacapsaicin (CA-008), a prodrug of Capsaicin and a first-in-class non-opioid TRPV1 agonist, offers significant and enduring pain relief.

ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, belonging to the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, resulting in the release of a fatty acid and a lysophospholipid. ROC-0929 holds promise in researching inflammation-related diseases.