Others

GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antagonist 3 holds potential as a novel antiplatelet agent [1].

TCO-PEG3-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

BAY-771是一种BAY-069的阴性对照和结构类似物，在Caco-2细胞中具有高渗透性，对BCAT1具有极弱的抑制活性，对BCAT2无活性。BAY-069是一种BCAT1/2抑制剂和化学探针，用于研究癌症和支链氨基酸代谢。

N-(Biotin-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker molecule employed in the synthesis of PROTACs[1].

Cyclo(L-Phe-trans-4-hydroxy-L-Pro) (Cyclo(L-phenylalanyl-trans-4-hydroxy-L-proline))是一种存在于Phellinus igniarius 中的天然产物。

Hydroxy-PEG5-C2-methyl ester is a polyethylene glycol (PEG) derived linker compound employed in PROTAC (PROteolysis TArgeting Chimeras) synthesis[1].

FWM-3是一种有效的 SARS-CoV-2 NSP13解旋酶抑制剂。

Carumonam, an antibiotic, could enhance the reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5.

CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the

Nucleoside Phosphoramidites;Arabino-nucleosides

1,1-Diethoxypropane是一种缩醛，主要用作有机合成中间体，用于保护醛基。

Genistein 7-O-glucuronide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4125，CAS号为 38482-81-4。

5-HT7 antagonist

Ninerafaxstat trihydrochloride 将细胞代谢由脂肪酸氧化转变为葡萄糖氧化。 Ninerafaxstat trihydrochloride 改善整体线粒体呼吸并减少脂肪酸氧化，从而抑制癌细胞的增殖和生长。

Ocedurenone, a corticosteroid receptor antagonist, is a compound utilized in the investigation of kidney disease (WO2018054357, compound I).

Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demonstrates the ability to penetrate the central nervous system [1] [2].

Glyceryl 2-Caprate (2-Monocaprin)是一种甘油酯，可用于生物化学实验和药物合成研究。

Chlorin e6 trimethyl ester, a derivative of methyl pheophorbide-a, is an effective photosensitizer for photodynamic therapy (PDT).

AChE/BChE-IN-9 (Compound 7a) is a potent orally active inhibitor of AChE and BChE, with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. It also demonstrates effective antioxidant activity, with an IC50 value of 57.35 μM. Additionally, AChE/BChE-IN-9 exhibits the ability to chelate iron and modulate the aggregation of amyloid β 1-42. Notably, AChE-IN-16 has the ability to cross the blood-brain barrier [1].

CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively (WO2019207463A1, example A93).

8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3) 是一种可以从Bidens bipinnata 分离得到的天然产物。8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside 在 0.556 mg/mL 时对α-amylase 有 22% 的抑制作用。

(S)-Rasagiline mesylate is rasagiline S-isomer, and is an agent of anti-Parkinson.

Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].

Azido-PEG5-triethoxysilane serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Mifamurtide protects mice against herpes simplex virus type 2. It also is a macrophage activator.

LasR-IN-4 是 LasR 的有效抑制剂，可抑制铜绿假单胞菌及其生物膜的形成、绿脓素和鼠李糖脂的产生。

Benzoquinoquinoxaline（BQQ）是一种具有氨基烷基侧链的杂环化合物，含有苯并和喹啉环结构。BQQ是三螺旋特异性稳定化合物，通过优先结合到DNA三重结并插入碱基之间。BQQ与1,10-phenanthroline的复合物能够特异性地结合并在形成三重结构的位点上切割双链DNA。

8-Nitroguanine 是由活性氮物引起的 DNA 硝化损伤的产物，可能是恶性纤维组织细胞瘤进展的潜在生物标志物。

Antileishmanial agent-10 (Compound 7h) 是一种抗原虫 (antiprotozoal) 剂。

5-Pentadecylresorcinol (Adipostatin A) 对埃及伊蚊具有良好的杀幼虫活性，它是甘油3-磷酸脱氢酶 (GPDH) 抑制剂，IC50值为 4.1 μM。

PF 03709270 is an orally available ester prodrug form of sulopenem. It has broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.

Benzyl-PEG5-NHBoc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Aminooxy-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol (PEG)-based linker primarily utilized in PROTAC synthesis for the development of proteolysis-targeting chimeras (PROTACs)[1].

DNP-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.