Others

DNA crosslinker 3 (dihydrochloride) (compound 1) 为一种与DNA结合的小沟结合剂，其结合亲和力(ΔTm)达1.4°C，常用于抗癌研究。

Pinocembrin diacetate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4792，CAS号为 111441-88-4。

NH2-C2-amido-C2-Boc is an alkyl/ether-based PROTAC linker employed in the synthesis of various PROTACs, including the PROTAC CDK2/9 Degrader-1[1]. NH2-C5-NH-Boc can also serve as a suitable precursor for the synthesis of these PROTACs.

SBP-3264是一种常用于研究急性髓性白血病中 STK3和 STK4左右价值的化学探针。

DCCCyb is an orally bioavailable and selective GlyT1 Inhibitor. DCCCyb demonstrated excellent in vivo occupancy of GlyT1 transporters in rhesus monkeys as determined by the displacement of a PET tracer ligand.

Biotin-PEG7-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 TNU0961，CAS号为 875302-45-7。

Misoprostol acid, an active metabolite of Misoprostol, is used for treating non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers.

(+)-Coclaurine 是从多种植物来源中分离出来的四氢异喹啉生物碱，具有抗衰老作用。

Mal-NH-PEG8-CH2CH2COOPFP ester is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].

Minocromil is a new agent of Anti-asthmatic.

2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].

Pulchinenoside K是一种发现于Anemone rivularis的三萜皂苷，对HSC-T6细胞具有抗增殖活性（IC50=18.21 µM）。

MK-447 is a nonsteroidal antiinflammatory agent.

TLR7 agonist12 (example 20) 是一种针对惰性淋巴系统恶性肿瘤具有广泛抗肿瘤活性的TLR7激动剂及嘌呤核苷类似物。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)来实现。

MIND4-17为一种NRF2激活剂，通过共价修饰Keap1的C151残基发挥作用。该化合物能破坏Keap1-Nrf2之间的结合，进而促进Nrf2蛋白的稳定性及其向核内的迁移，显示出显著的抗氧化活性。

Kadsurenone is a platelet-activating factor receptor antagonist from Chinese herbal plant, haifenteng. It is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling pathway.

Anticancer agent 170 (compound 3a)，一种酮类衍生物，展现出对A549细胞株显著的抗癌效力，其半抑制浓度（IC50）为6.62 μM。

Aladorian (ARM036) is a benzothiazepine derivative and it has anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2].

EFdA-TP, a highly potent nucleoside reverse transcriptase (RT) inhibitor, exerts its inhibitory effect on RT-catalyzed DNA synthesis through both immediate and delayed chain termination mechanisms, commonly referred to as ICT and DCT, respectively. Additionally, EFdA-TP demonstrates its efficacy in inhibiting HIV-1 RT through multiple pathways.

VEGFR-2-IN-19 (Compound 15b) is a highly efficacious inhibitor of VEGFR2, a receptor involved in angiogenesis. Its mechanism of action involves the induction of cellular apoptosis and elevation of intracellular reactive oxygen species. Due to these properties, VEGFR-2-IN-19 holds promise as an effective anticancer agent [1].

10-Hydroxyscandine是一种天然产物，属于夹竹桃科山橙属，其产品编号为 TN2570，CAS号为 119188-47-5。10-Hydroxyscandine可用作对照参考。

Antibacterial agent 101 表现出抗细菌和抗真菌作用(MIC=4-32 μg/mL)。

Indoxyl sulfate (Standard) 是一种可用于分析的标准物质，通常用作 Indoxyl sulfate 的研究和分析中参考的标准样品。Indoxyl sulfate 是色氨酸的代谢产物，会对骨骼和中枢神经系统产生不良影响，且最常被指认为是导致肾病恶化和血管疾病的一个因素。

SCH-451659 is an 17β-hydroxysteroid dehydrogenases (17β-HSDs) inhibitor.

ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100, an activator of the stimulator of interferon genes (STING).

(2E)-Hex-2-en-1-yl Hexanoate是一种酯类化合物，广泛应用于生物化学实验和药物合成研究。

Vanitiolide (Vanitiolid) 是一种具有利胆作用的药物。

DAO-IN-2是一个片段分子，CAS号为39793-31-2，可作为分子拼接、扩展和修饰的重要骨架，为新型候选药物的设计与筛选提供结构基础与研究工具，常用于药物发现、药物合成等相关研究。

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)

Tubulin polymerization-IN-9 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 1.82 μM)。Tubulin polymerization-IN-9 能够将 K562 细胞的细胞周期停滞在 G2/M 期，并诱导其凋亡 (apoptosis) 及线粒体去极化。Tubulin polymerization-IN-9 表现出强大的抗血管和抗肿瘤作用。

L-156,602 在生命科学相关研究中具有广泛的应用。

FTEAA为4-苯乙烯基哌啶类MAO抑制剂，对MAO-A与MAO-B展现出显著的抑制活性，其IC50值分别为0.52 μM与1.02 μM。该类抑制剂在心血管、神经系统及肿瘤相关研究中有广泛应用。

CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM).

Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.

Nucleoside Derivatives - 6-Modified purine nucleosides; Halo-nucleosides; Fluoro-modified nucleosides