Parasite

Lucilactaene 展现出卓越的抗疟活性，是一种 P53 转染的肿瘤细胞周期抑制剂，能够抑制 H1299/TSP53 在 G1 期的细胞周期进程。

Bulaquine is a derivative of 8-aminoquinoline and has effective activity against the liver stage of plasmodium falciparum and the dormant bodies of Plasmodium vivax and Plasmodium ovale.

Milbemycin α11 (Meilingmycin A) 是一种抗生素，具有线虫和螨虫的杀灭作用。

5,7,8-Trimethoxydictamnine is a quinoline alkaloid that has been found inRutaceaeand has antimalarial activity.1It is active against chloroquine-sensitive and -resistant strains ofP. falciparum(IC50s =19.9 and 5.72 μg/ml, respectively). 1.Basco, L.K.M., S., Skaltsounis, A.-L., Ravvelomanantsoa, N., et al.In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparumAntimicrob. Agents Chemother.38(5)1169-1171(1994)

WR-27653 (RC-12) 为 Catechol 衍生物，在金标准食蟹猴疟原虫 (Plasmodium cynomolgi)-恒河猴 (Macaca mulatta) 模型中，对休眠子表现出显著活性，并展现了抗疟特性。

(S)-Praziquantel 是 R-praziquantel 的无活性异构体。

Hynapene B 对艾美耳球虫的抑制作用呈现出 MIC [minimum inhibitory concentration] 为 34.7 μM。

Cytosaminomycin A 是一种抗生素，具备抗球虫和抗菌活性。

Pyriprole 可用于猫蚤。此化合物通过在成年跳蚤产卵前将其杀死，破坏了跳蚤的生命周期。Pyriprole 对狗的粪便有残留效应，导致猫蚤幼虫发育成成虫的能力下降。

Primidophos 是一种包含在杀虫杀螨组合物中的成分，可用于虫害和螨害的防治研究。

Falcipain-2/3-IN-2 (Compound 12) 是一种falcipain-2和falcipain-3的双重抑制剂。

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disea

Quinidine Monosulfate 是一种抗心律失常剂。Quinidine Monosulfate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+通道 (K+channel) 的有效阻断剂，其 IC50值为 19.9 μM。Quinidine Monosulfate 也可用作疟疾的研究。

Antiparasitic agent-7 (compound 5d) displays specific antiparasitic activity against Leishmania infantum (L. infantum), exhibiting an IC50 value of 2.85 μM. Additionally, Antiparasitic agent-7 demonstrates cytotoxicity against HepG2 cells with a CC50 value of 10.61 μM [1].

Nitroscanate is an anthelmintic found to be effective in certain strains of parasites in canines.

Quinidine sulfate 是一种抗心律失常剂，是有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+通道 (K+channel) 的有效阻断剂，其IC50值为 19.9 μM。Quinidine sulfate 也可用于疟疾的研究。

HDAC6-IN-27 (compound 8C) 作为一种HDAC抑制剂，其对 HDAC6、HDAC8 和 HDAC1的IC50值分别为 15.9 nM、136.5 nM 和 6180.2 nM。该化合物表现出显著的抗寄生虫活性。

CA-IN-5g is an effective carbonic anhydrase (CA) inhibitor. Carbonic anhydrase is isolated from Trypanosoma cruzi (TcCA).

Proclonol is used as a pesticide.

(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial.

Antitrypanosomal agent 9 是一种有效的抗锥虫体剂。Antitrypanosomal agent 9 显示出对T. b. brucei 的抑制活性，其IC50为 1.15 μM。Antitrypanosomal agent 9 可用于人类非洲锥虫病 (HAT) 研究。

AB 3217-C is an anti-mite substance isolated from streptomycete strain.

Metronidazole acetic acid 是 Metronidazole 的代谢产物，在细菌中具有诱变活性。Metronidazole 是硝基咪唑类抗生素，杀螨剂和抗原生动物剂。

alpha-Artemether is a Quinghaosu derivative with antifungal and antimalarial activity.

Vamidothion is a polar organophosphorus insecticide and acaricide

Quinoprazine, a powerful inhibitor of Vaccinia virus DNA synthesis (IC50 = 10 μM), exhibits notable antimalarial activity against Plasmodium berghei. Additionally, it demonstrates significant antiprion potency, effectively reducing levels of PrPSc [1]-[5].

L 693989 is a pneumocandin.

APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.

BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 shows to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM).

OAT-2068 是一种有效且选择性的小鼠壳三糖苷酶 (CHIT1) 抑制剂，与 mAMCase 相比，mCHIT1 的选择性高出 143 倍。

Emoquine-1 是一种强效口服抗疟药，对多种耐药性疟原虫有效，包括对青蒿素耐药的静止期疟原虫和增殖性恶性疟原虫，IC50值为 20-55 nM。Emoquine-1 有望用于抵抗对青蒿素联合疗法 (ACT) 耐药的疟原虫，能够消除持久性寄生虫。

Chinifur is a selective inhibitor and subversive substrate" for Trypanosoma congolense trypanothione reductase"

Cardoldiene 是一种天然化合物，可作为天然产物对照品，其 CAS 号为 79473-25-9。

Imidocarb是一种有效的抗原虫剂，对寄生虫B. bovis具有活性，IC50为87 μg/mL。

DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y strain), giving IC(50)s of 60 and 25 nM

Conessine hydrobromide is a naturally occurring steroid alkaloid and has been used in traditional herbal medicine as a treatment for amoebic dysentery.