Parasite

Arterolane, an adenosine triphosphatase inhibitor, is used potentially for the treatment of malaria.

2,3-Dehydro-3,4-dihydro ivermectin is an analog of ivermectin and an anthelmintic. 2,3-Dehydro-3,4-dihydro ivermectin has activity against L. amazonensis promastigotes and amastigotes ( IC 50 s=13.8 and 3.6 μM, respectively) without inducing cytotoxicity to macrophages ( IC 50 = 65.5 μM).

NIC is an inhibitor of host invasion. It is also an inhibitor of VEGF binding to immobilized heparin.

Allosamidin, a chitinase inhibitor and typical secondary metabolite of Streptomyces, may be used as a pesticide and anti-asthmatic agent.

AB 3217-B is an anti-mite substance isolated from streptomycete strain.

DSM1465 (Compound 82) 是高效选择性的P. falciparum二氢酸脱氢酶 (PfDHODH) 抑制剂，IC50为15 nM，可以抑制P. falciparum3D7 (Pf3D7) 寄生虫，EC50为1.4 nM。在人源化P. falciparum小鼠模型中，DSM1465 展现出强大的体内活性。

Pulixin 阻碍了 FREP1 与恶性疟原虫感染细胞的裂解物的结合，防止传播至蚊子，其中EC50值为11 µM。同时，Pulixin 抑制无性期恶性疟原虫的增殖，EC50值达47 nM。

Cevadine 是一种天然化合物，可作为天然产物对照品。

D44 is a Plasmodium FKBPs inhibitor.

Symetine dihydrochloride (L 16726 dihydrochloride) 是 Symetine 的二盐酸盐形态，具有针对 Entamoeba histolytica 的抗原虫效力，并可改善豚鼠阿米巴肝脓肿。

Etofamide，作为一种抗微生物剂，具有显著的阿米巴虫抑制作用，其IC50值为5.96 mg/L。

LN002 是一款口服活性抗隐孢子虫氧化酶抑制剂，主要用于探索隐孢子虫病的研究用途。

LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1].

Diclazuril K is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed.

Antimalarial agent 15 是 parasite 抑制剂，表现出抗疟作用，对恶性疟原虫 3D7 的生长具有抑制作用，其 IC50值为20 nM。

Buquinolate (Bonaid TM) 是一种用于家禽的抗球虫剂，用药后的鸡可以产生更高水平的产蛋量和体重增加。它不会干扰对球虫的免疫力的形成。

Phosphodiesterase-IN-1 (Compound 7) 为一种针对磷酸二酯酶（PDE）的抑制剂，表现出对疟原虫的活性。该化合物在抑制P. falciparum（strain 3D7）的增殖方面表现有效，其IC50为0.64 μM。

Quinidine hydrobromide 是有效的、选择性的的、具有口服活性的细胞色素 P450db (cytochrome P450db) 抑制剂。Quinidine hydrobromide 是 K+通道 (K+channel) 的有效阻断剂（IC50= 19.9 μM）。Quinidine hydrobromide 具有抗心律失常的作用。Quinidine hydrobromide 也可用作疟疾的研究。

RS 49676 is an N-substituted imidazole.

TbPTR1 inhibitor 1 (compound 5d) 是有效的动基体蝶啶还原酶 1 (PTR1)抑制剂。TbPTR1 inhibitor 1抑制布氏锥虫 PTR1 (TbPTR1) 的 IC50<0.1 nM，抑制布氏锥虫 (Trypanosoma brucei) 活性的 EC50=0.66 μM。

Luxabendazole is a benzimidazole carbamate broad-spectrum anthelmintic agent. It has proved to be effective against immature and adult stages of the major gastrointestinal nematodes, cestodes, and trematodes.

Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages.

AB 3217-A, an anti-mite substance isolated from the fermentation broth of a streptomycete strain, shows marked activity against the two spotted spider mite, Tetranychus urticae.

Anti-Trypanosoma cruzi agent-4是克氏锥虫抑制剂。Anti-Trypanosoma cruzi agent-4 可用于感染的研究。

Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways.

Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODH.

Pam 1392 is a chemotherapeutic agent.

Antiparasitic agent-6 (compound 5b) 对婴儿利什曼原虫表现出选择性抗寄生活性 (IC50 = 3.89 μM)。Antiparasitic agent-6 还对 HepG2 细胞表现出一定的细胞毒性，CC50值为 13.64 μM。

Picarbutrazox是一款用于玉米和大豆的强效杀虫剂及杀菌剂，专门针对腐霉和疫霉的防治。该化合物在农业生产中用于病害防治具有显著效果。

Antiparasitic agent-8 (Compound 9) exhibits potent antiparasitic activity against Hymenolepis nana, while demonstrating low levels of cytotoxicity [1].

Antiparasitic agent-5 (compound 8h) exhibits potent selectivity as an antiparasitic agent against Leishmania infantum (L. infantum), with an IC50 value of 2.50 μM. Additionally, this compound displays cytotoxic effects on HepG2 cells with a CC50 value of 6.78 μM [1].

L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.

Metronidazole hydrochloride (SC 326421) 是一种有口服活性的硝基咪唑抗生素，适用于厌氧微生物感染的研究。该化合物能穿越血脑屏障，长期服用可能引发炎症和骨骼肌收缩问题。

(R)-Dinotefuran ((R)-MTI-446) 是一种新烟碱类农药，与消旋混合物相比，通过抑制烟碱乙酰胆碱受体 (nAChR) 对典型的吸吮性害虫Aphis gossypii 和Apolygus lucorum 表现出相当的杀虫活性 (1.7-2.4 倍)。(R)-Dinotefuran 具有良好的防治目标害虫的作用，同时减少对蜜蜂的危害。

MMV674850 exhibits potency against asexual stage parasites, with IC50 values of 2.7 and 4.5 nM. Furthermore, it demonstrates a preferential affinity for early-stage gametocytes, displaying an IC50 value of 4.5 ± 3.6 nM, compared to late-stage gametocytes with an IC50 value of 28.7 ± 0.2 nM.