Parasite

Carnaubadiol is a triterpene that has been found in E. corollata and has antiprotozoal activities.1,2 It is active against L. infantum promastigotes and amastigotes, as well as T. cruzi trypomastigotes (IC50s = 46.2, 7.8, and 14.9 μM, respectively).2 |1. Piatak, D.M., and Reimann, K.A. Plant investigations IV. Corollatadiol A new triterpene from euphorbia corollata. Tetrahedron Lett. 13(44), 4525-4528 (1972).|2. de Almeida, B.C., Araújo, B.Q., Carvalho, A.A., et al. Antiprotozoal activity of extracts and isolated triterpenoids of 'carnauba' (Copernicia prunifera) wax from Brazil. Pharm. Biol. 54(12), 3280-3284 (2016).

Glaucarubin 是一种存在于苦木果 (Simaruba glauca) 中的苦味内酯，常用于阿米巴病研究中的抗阿米巴剂。它具有良好的耐受性，对小鼠的半数致死剂量 (LD50) 为 1,600 mg/kg，而对大鼠的 LD50 为 6,400 mg/kg。

WC-9 is a squalene synthase inhibitor. It acts by binding to TcSQS and HsSQS.

Antileishmanial agent-16 (化合物 14c) 是一种针对Leishmania的抗原虫剂，表现出针对Leishmaniamajor前鞭毛体的高效活性（IC50=0.59 µM）以及对Leishmaniamajor无鞭毛体的有效活性（IC50=0.81 µM）。此外，Antileishmanial agent-16对哺乳动物细胞（VERO 细胞）的毒性低，说明其具有较好的安全性。

Antimalarial agent 24（Compound 7）是一种抗疟化合物，具有显著的体外（in vitro）活性。针对P. falciparum W2菌株，其IC50值为0.81 μM。同时，Antimalarial agent 24展现在HepG2细胞上的CC50值高于200 μM，表明其对宿主细胞具有较高安全性。

Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂，其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶，IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。

Antimalarial agent 29 (compound 16) 作为一种效力较高的抗疟化合物，其针对伯氏疟原虫肝期寄生虫的EC500值达到5.2 μM。

Ornidazole diol is a diol produced through ornidazole rapidly hydrolyzing in basic solutions.

Nopol is an inhibitor of alpha-glucosidase.

Cannflavin B，一种从Cannabis sativa L. 分离得到的异戊二烯化黄酮，表现出抗炎活性。

Tilbroquinol is an antiprotozoal agent effective against amoebiasis.

PIQ-2 (compound 54) 作为一种抗原虫剂，对IP. falciparum 3D7和B. divergens Rouen展示出的IC50值分别为 9.4 nM 和 1.6 nM。

Sitamaquine hydrochloride (WR 6026)，一种具口服活性的8-aminoquinoline衍生物，能有效抗利什曼病。该化合物主要通过抑制线粒体复合物II（琥珀酸脱氢酶）发挥作用。作为一种嗜脂性弱碱，Sitamaquine hydrochloride 在利什曼原虫的酸性环境中能快速积累，尤其是在酸钙小体内部。

Z-Pro-Pro-CHO为一种有效的脯氨酰寡肽酶抑制剂，其具有针对人类及曼氏血吸虫脯氨酰寡肽酶的较低半抑制浓度（IC50），分别为0.16 μM和0.01 μM。

Antiparasitic agent-10 (Compound 94) is a potent anti-parasitic agent specifically designed to target and combat parasitic infections. It demonstrates notable anti-schistosomal activity, particularly against adults of Schistosoma mansoni. As a result, this compound holds significant potential for utilization in Schistosomiasis research as a viable treatment option [1].

Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 μM, respectively).1

Agathisflavone is a NS2B-NS3 proteases inhibitor of the Dengue virus serotypes 2 and 3.

Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM).

Brilliant green, a cationic dye, is utilized for coloring silk and wool. Additionally, it halts the propagation of mold, intestinal parasites, and fungus, proving effective against Gram-positive bacteria [1] [2].

3-Deoxyaphidicolin 是一种植物毒素，对莴苣幼苗根部生长有抑制作用，并对利什曼原虫 Leishmania major 和 Leishmania braziliensis 展示抑制活性。

Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.

NEU-730, a novel inhibitor of TbrPDEB1, shows modest inhibition of T. brucei proliferation.

J1075 is an histone deacetylase 8 (HDAC8) inhibitor.

RO-09-4609 is a potent and selective inhibitor of Candida albicans N-myristoyltransferase (CaNmt).

Leukoefdin is a colorless chemical compound related to leucoanthocyanidins.

Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.

SARS-CoV-IN-1 is an effective SARS-CoV replication inhibitor(EC50 of 4.9 μM in Vero cells).

Semduramicin sodium is a carboxylic acid ionophore for management of chicken coccidiosis.

(R)-Hydroxychloroquine ((R)-HCQ) phosphate 是 Hydroxychloroquine 的一种异构体。(R)-Hydroxychloroquine 可抑制正常和糖尿病条件下大鼠肝匀浆细胞质的胰岛素代谢酶。

Ronidazole (Ronidazol) 是一种口服有效的抗原虫和抗菌试剂。它在猫模型中对胎儿三毛滴虫有效，还可研究组织口癣和猪痢疾。

MMV006833是一种针对Plasmodiumfalciparum的有效抑制剂，其作用机制是靶向脂质转移蛋白PfSTART1，从而阻断Plasmodiumfalciparum在环状期的发育。

Lavandulyl acetate is a component of lavender oil.

Ivermectin in Acetonitrile (Standard) 是一种可用于分析的标准物质，通常用作 Ivermectin 的研究和分析中参考的标准样品。Ivermectin 是一种抗寄生虫化合物，可用于寄生虫感染。

Avermectin B1a in Acetonitrile (Standard) 是一种可用于分析的标准物质，通常用作 Avermectin B1a 研究和分析中参考的标准样品。Avermectin 是一种从从土壤中分离出来发酵链霉菌中提取的化合物，可降低 Caspase-8 和 Bcl-2 的表达。

Clorsulon (L631529) 是一种具有口服活性的灭虫试剂，用于犊牛和羊的肝吸虫 感染。它也是 3-磷酸甘酸酯和 ATP 的竞争性抑制剂，可抑制成熟肝片吸虫对葡萄糖的利用以及乙酸和丙酸的形成。