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Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
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Integrase
Parasite
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Reverse Transcriptase
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信号通路
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Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT213886588
Horminone
TN4227
21887-01-4
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi, 30 microM drug concentration producing total inhibition of growth. After administration of plant extracts containing Horminone has possibility of toxic effect.
Antibacterial
Antifection
DNA/RNA Synthesis
NADPH-oxidase
HIT214315455
Methyl protogracillin
TJS1748
54522-53-1
Methyl protogracillin 是来自 Dioscorea collettii var. hypoglauca 的天然产物,具有抗癌活性。
Antifection
HIT212665683
(+)-Medioresinol
TN1919
40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable antiamyloidogenic agent for the prevent
Akt
Antibacterial
Antifection
Antifungal
Apoptosis
Beta Amyloid
Interleukin
MMP
mTOR
PGC-1α
PI3K
PPAR
Pyroptosis
Reactive Oxygen Species
ROS
HIT213885700
Octadecyl p-coumarate
TN4692
72943-88-5
A mixture of (E)-octadecyl p-coumarate and (Z)-octadecyl p-coumarate has antifungal activity , it shows the dose dependent inhibition of the spore germination of Alternaria alternata and A. porri.
Antifection
HIT212665372
Colutehydroquinone
TN1521
181311-16-0
Colutehydroquinone 是一种从Colutea arborescens 的根皮中提取的异黄酮,具有抗真菌活性。
Antifection
Antifungal
HIT212665287
Azadirachtin
TN1417
11141-17-6
Azadirachtin 是一种有前途的植物源杀虫剂,能够诱导昆虫 Sf9、SL-1 和 BTI-Tn-5B1-4 细胞凋亡。它广泛用于害虫防治。
Antifection
Apoptosis
Bcl-2 Family
Caspase
NF-κB
Parasite
HIT213886333
Taxiphyllin
TN5117
21401-21-8
Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against Staphylococcus aureus.
Antifection
Tyrosinase
HIT101995735
Carpinontriol B
TN3603
473451-73-9
Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows considerable inhibition on the production of nitric oxide and reduces the production of interleukin-6 in dose-dependent manner in RAW 264.7 cells.
Antifection
IL Receptor
HIT213131547
6-Methyl-5,6-dihydropyran-2-one
TN3177
108-54-3
6-Methyl-5,6-dihydropyran-2-on is bactericidal,and antiprotozoal agents.
Antibacterial
Antibiotic
Antifection
Antifungal
Parasite
HIT214315953
Humulene epoxide II
TN4229
19888-34-7
Humulene epoxide II has antimalarial activity.
Antifection
HIT214316039
Methyl 6-hydroxyangolensate
TN4536
22255-07-8
Methyl 6-hydroxyangolensate shows antifungal and antibacterial activities.
Antifection
Parasite
HIT214314559
Mogroside VI
TN1938
189307-15-1
Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga
Antifection
HIT213884563
Arteannuin N
TN3453
207446-92-2
Arteannuin N is one of the main component of Arteannuin. Arteannuin has antimalarial activity. Arteannuin can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
Antifection
Parasite
TNF
HIT213885661
6-Deoxyjacareubin
TN3161
16265-56-8
6-Deoxyjacareubin 具有有效的抗氧化和抗真菌活性。 6-Deoxyjacareubin 抑制血小板活化因子 (PAF) 受体,IC50 为 29.0 microM,可用于天然 PAF 受体拮抗剂的研究。
Antifection
Antioxidant
PAFR
Platelet aggregation
Reactive Oxygen Species
HIT213886590
Sageone
TN4932
142546-15-4
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity.
Akt
Antifection
Apoptosis
Caspase
PARP
HIT212665136
(2S)-2'-Methoxykurarinone
TN1215
270249-38-2
(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。
Akt
Antifection
RANKL/RANK
HIT214316188
Shoreic acid
TN5014
21671-00-1
Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
Antifection
HSV
HIT213886352
1,7-Dihydroxy-2,3-methylenedioxyxanthone
T4484
183210-63-1
1,7-Dihydroxy-2,3-methylenedioxyxanthone exhibits antiulcerogenic, anti-oxidation, and antihyperalgesic activities and can inhibit carrageenan-induced hyperalgesia.
Antifection
Prostaglandin Receptor
HIT212665233
8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone
TN1344
1000415-56-4
8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone may have antifungal activity against phytopathogenic and human pathogenic fungi.
Antifection
HIT212665954
Thalrugosaminine
TN2271
22226-73-9
Thalrugosaminine shows promising antibacterial activity with MIC values of 64-128ug/ml and Staphylococcus species is the most sensitive strains. Thalrugosaminine possesses hypotensive activity in rabbits and is active against Mycobacterium smegmatis.
Antibacterial
Antifection
HIT212665068
Veraguensin
TN1117
19950-55-1
Veraguensin 来源于 Magnolia sp.。 Veraguensin 抑制骨吸收并显示出高抗寄生虫活性。
Antibiotic
Antifection
NF-κB
p38 MAPK
Parasite
HIT212687431
Furomollugin
TN2417
61658-41-1
Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells.
Antibacterial
Antifection
HIT101420085
Nigracin
TN4656
18463-25-7
Nigracin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4656,CAS号为 18463-25-7。
Antifection
HIT213886121
Isobonducellin
TN4266
610778-85-3
Isobonducellin exhibits potent cytotoxic activity in Jurkat and HepG2 cells, while moderate growth inhibition against Colon205 cells.
Antibacterial
Antifection
HIT213884971
14-Deoxycoleon U
TN2625
88664-09-9
14-Deoxycoleon U has anti-termitic activity, it is highly active against both wood-decay fungi. 14-Deoxycoleon U shows antibacterial activity against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and
Antifection
HIT212652381
zerumbone
T5712
471-05-6
Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离的一种单环倍半萜烯,可有效抑制Epstein-Barr 病毒的激活,IC50为 0.14 mM,具有抗癌、抗炎、抗氧化和抗增殖的作用。
Antibacterial
Antifection
Antioxidant
Apoptosis
Caspase
HSV
HIT213886544
Thalifoline
TN5139
21796-15-6
Thalifoline shows antifungal activity, with 100 ug against Fusarium oxysporum f. sp. lycopersici.
Antifection
Antifungal
HIT213887154
(+)-Nortrachelogenin
TN4673
61521-74-2
(+)-Nortrachelogenin 是一种从 Wikstroemia indica C.A. Meyer (百里香科)中分离出来的木脂素。 (+)-Nortrachelogenin 具有抗白血病活性。
Antifection
Apoptosis
HIV Protease
PI3K
HIT213886325
Communic acid
TN3691
2761-77-5
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.
Akt
Antibacterial
Antifection
DNA/RNA Synthesis
MAPK
MMP
PI3K
HIT213885074
beta-Amyrone
TN3500
638-97-1
beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性,EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
AChR
Antifection
Antifungal
COX
PPAR
HIT213885289
1,4,7-Eudesmanetriol
TN2495
145400-02-8
1α,4β,7β-Eudesmanetriol and 1β,4β,7β-Eudesmanetriol can inhibit growth of Pseudomonas stutzeri with a MIC value of 117 uM, they also show remarkable activities against acetylcholinesterase enzyme with IC50 values ranging between 25 and 26 uM.
Antifection
HIT212665377
Corydalmine
TN1526
30413-84-4
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent.
Antifection
Antifungal
CXCR
Cytochromes P450
HIT213884394
1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
TN2515
332371-82-1
(4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one shows growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes, with the IC(50) value in the range of 1-3 microg/mL.
Antifection
Melanocortin Receptor
Others
HIT214315487
1-Methoxyphaseollidin
TMA2418
65428-13-9
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Methoxyphaseollidin may show moderate cytotoxic activity against KB and L1210 cells. 1-Methoxyphaseollidin also shows inhibition of lysoPAF acetyltransferase activity.
Antibacterial
Antifection
Endogenous Metabolite
PAFR
HIT213885791
2'',4''-Di-O-(E-p-coumaroyl)afzelin
TN2711
163434-73-9
Antimicrobial agent.
Antifection
Others
HIT213886322
8(14),15-Isopimaradien-3-ol
TN3260
4728-30-7
ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than 10 microg /mL for most pathogens).
Antifection
Calcium Channel
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