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Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
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Parasite
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信号通路
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Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT213885392
6-Acetonyl-N-methyl-dihydrodecarine
TN3151
1253740-09-8
6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.
Antifection
Monoamine Oxidase
HIT213885275
5-Hydroxysophoranone
TN3124
90686-12-7
5-Hydroxysophoranone 从 Erythrina subumbrans 茎中提取,对恶性疟原虫具有高抗疟原虫活性 (IC50 = 2.5 μg/mL)。
Antibacterial
Antifection
Parasite
HIT213885609
Corymbosin
TN3713
18103-41-8
Corymbosin shows significant antiviral activity.
Antifection
Antifungal
HIT213885172
Barbinervic acid
TN3490
64199-78-6
Barbinervic acid shows anti-bacteria activity (IC50 = 0.098 g x LU(-1), IC50 = 0.27 g x L(-1)) against SA and ESBLs-SA respectively.
Antifection
Glutaminase
HIT213886981
Tagitinin A
TN5091
59979-61-2
Tagitinin A (肿柄菊内酯 A)是一种天然的倍半萜内酯化合物,作为过氧化物酶体增殖物激活受体α/γ(PPARα/PPARγ)的双重激动剂,在糖尿病研究中发挥抗高血糖和抗高血脂作用。Tagitinin A 能够直接结合PPARγ配体结合域(IC50=55 μM),也能刺激PPARα依赖性SULT2A1基因启动子的转录激活。作为植物毒素时Tagitinin A对小麦胚芽鞘的生长有显著的抑制作用。
Antifection
PPAR
HIT213884834
Cerbinal
TN3626
65597-42-4
Cerbinal 是一种天然化合物,来源于非洲非洲菊的草本植物。它具有杀虫活性,是一种潜在的新型害虫防治剂。
Antifection
Antifungal
HIT213885579
Goniodiol
TN4159
96422-52-5
(+)-Goniodiol and 7-epi-(+)-Goniodiol show high antibacterial activity (MIC, 3.1 mM) against Yersinia intermedia.
Antifection
HIT213886610
Danshenxinkun D
TMA0395
98873-76-8
Danshenxinkun D has antituberculosis H_(37)Rv activity in vitro.
Antifection
Dopamine Receptor
HIT212665352
Cimigenol-3-one
TN1497
31222-32-9
Cimigenol-3-one is a natural product from Calophyllum inophyllum.
Antifection
Others
HIT213123687
Gancaonin G
TN4097
126716-34-5
Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.
Antibacterial
Antifection
HIT213840672
Kamebanin
TN4375
39388-57-3
Kamebanin 是一种天然二萜类化合物,具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。
Antifection
HIT214315685
Agatharesinol acetonide
TN3355
800389-33-7
Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM).
Antifection
HIT214316198
Beta-Solamarine
TN5034
3671-38-3
Beta-Solamarine has antibacterial activity.
Antibacterial
Antifection
HIT213886603
1,2-Dihydrotanshinone
TN2485
77769-21-2
1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Antifection
DNA/RNA Synthesis
HIT212665680
Marmin
TN1913
14957-38-1
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.
Antifection
Calcium Channel
Histamine Receptor
HIT212665586
Isorhamnetin 3-glucoside-7-rhamnoside
TN1792
17331-71-4
An anti-oxidative composition containing isorhamnetin-3-glucoside-7-rhamnoside (IGR)isolated from Hippophae rhamnoides L. is provided to ensure antioxidative, antibacterial, and anti-cancer effect.
Antifection
HIT213885235
1(10)-Aristolen-2-one
TN2475
28398-06-3
1(10)-Aristolen-2-one has antifungal activity.
Antifection
HIT105165198
Kaempferol 3-O-arabinoside
TN1821
99882-10-7
Kaempferol-3-O-α±-D-arabinoside displays cytotoxic and high antioxidant activity.Kaempferol-3-O-arabinoside and kaempferol-3-O-glucoside can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging ROS, and protect cellular membrane against ROS; they can be applicable to new cosmeceuticals for antioxidant, antiaging, and antibacterial activity.
Antifection
ROS
HIT213885684
(-)-Heraclenol
TN4202
139079-42-8
(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.
Antifection
HIT213884953
Cleroindicin F
TN3680
189264-47-9
Cleroindicin F shows cytotoxic activity against some human cancer cells. Cleroindicin F and apigenin in the ethyl acetate extract provide scientific support to the traditional use of the leaves of C. splendens for the treatment of infections, wounds and o
Antibacterial
Antifection
HIT221062095
EBNA-1 (386–405 aa)
TP4007
3082858-70-3
EBNA-1 (386-405 aa) 是一种病毒抗原肽,其具备交叉反应能力。它与 GlialCAM (370-389 aa) 在分子结构上具有高度相似性,从而诱导产生能够识别 EBV 抗原和中枢神经系统神经胶质细胞的交叉反应抗体,进而引发自身免疫反应。EBNA-1 (386-405 aa) 可用于研究 Epstein-Barr 病毒 (EBV) 感染和多发性硬化症 (MS)。
Antifection
HIT212665026
Ganoderic acid B
TN1059
81907-61-1
Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂,抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
Antifection
HIV Protease
IL Receptor
JAK
STAT
HIT213885899
Lycorenine
T2S1727
477-19-0
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
Antibacterial
Antifection
HIT213886724
2,3-Dihydrohinokiflavone
TN2697
34292-87-0
2,3-Dihydrohinokiflavone 是基质金属蛋白酶 (MMP) 基因表达的抑制剂,对利什曼原虫具有很强的活性,IC50 为 1.6 μM。
Antifection
MMP
Parasite
HIT212665827
Primin
TN2101
15121-94-5
Primin 是存在于 Primula obconica 叶和茎毛状体中的天然产物,显示出抗菌和抗癌活性。
Antibacterial
Antifection
HIT213886799
Kushenol C
TN4399
99119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan
Antifection
BACE
Beta-Secretase
NF-κB
ROS
SGLT
HIT105787977
Narcissin
T6S1768
604-80-8
Narcissin (Isorhamnetin 3-Rutinoside) 是一种黄连糖苷,能够清除 ONOO-(IC50:3.5 μM)和 SIN-1 衍生的 ONOO-(IC50:9.6 μM),具有抗氧化作用。
Antifection
Antioxidant
HIT101751139
Licoricone
T3831
51847-92-8
Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
Antibacterial
Antifection
HIT213887501
Methyl lucidenate L
TN5980
110267-46-4
Methyl lucidenate L 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5980,CAS号为 110267-46-4。
Antifection
HIT213885041
Isolupalbigenin
TN4308
162616-70-8
Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
Antifection
NO Synthase
HIT214316075
Neridienone B
TN4649
61671-56-5
Neridienone B has significant effects on calcein accumulation. Neridienone exhibits significant leishmanicidal activity against amastigotes of L. mexicana.
Antifection
HIT213887343
Citromycin
TN3670
37209-30-6
Citromycin, an antibiotic, has weakly cytotoxic.
Antifection
HIT213885300
Cuniloside B
TN3729
1187303-40-7
Cuniloside B shows anti-leishmanial activity.
Antifection
HIT213884589
Artoheterophyllin B
TN3456
1174017-37-8
Artoheterophyllin B has antiplasmodial activity.
Antifection
Parasite
HIT212665492
Garcinone C
TN1673
76996-27-5
Garcinone C 是一种从 Garcinia oblongifolia Champ 中提取的黄酮衍生物,具有抗炎、收敛和促进肉芽的活性。 Garcinone C 是一种 AChE 抑制剂,对某些癌症具有潜在的细胞毒性作用。
AChR
Antifection
ATM/ATR
CDK
Hedgehog/Smoothened
STAT
HIT213884389
Vasicinolone
TN5223
84847-50-7
Vasicinolone has anti-inflammatory, and antimicrobial activities.
Antibacterial
Antifection
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