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Antifection
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Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
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Parasite
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信号通路
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Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT213886292
Nervogenic acid
TN4650
17622-86-5
Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.
Antibacterial
Antifection
HIT212665026
Ganoderic acid B
TN1059
81907-61-1
Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂,抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
Antifection
HIV Protease
IL Receptor
JAK
STAT
HIT213840511
Desciclovir
T22304
84408-37-7
Desciclovir (DCV) 是抗疱疹药物阿昔洛韦的前药,口服有活性,在体内被黄嘌呤氧化酶转化成为阿昔洛韦。
Antibacterial
Antibiotic
Antifection
Apoptosis
HSV
Others
HIT213885392
6-Acetonyl-N-methyl-dihydrodecarine
TN3151
1253740-09-8
6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.
Antifection
Monoamine Oxidase
HIT214315759
Caesalmin B
TN3563
352658-23-2
Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
Antibiotic
Antifection
HIT214315543
20-Deoxocarnosol
TN2798
94529-97-2
20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity.
Antifection
ROS
HIT100065449
Protoplumericin A
TN4834
80396-57-2
Protoplumericin A displays distinct activity against some pathogenic bacteria and fungi.
Antifection
HIT213884991
1-Methoxyberberine
TN2548
29133-52-6
1-Methoxyberberine chloride is a potential antifungal agent.
Antifection
Antifungal
HIT213885684
(-)-Heraclenol
TN4202
139079-42-8
(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.
Antifection
HIT213840672
Kamebanin
TN4375
39388-57-3
Kamebanin 是一种天然二萜类化合物,具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。
Antifection
HIT214316159
Swietemahalactone
TN5082
1514669-21-6
Swietemahalactone exhibits antibacterial activity.
Antibacterial
Antifection
HIT213885041
Isolupalbigenin
TN4308
162616-70-8
Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
Antifection
NO Synthase
HIT214315749
Bullatantriol
TN3547
99933-32-1
Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.
Antifection
HIT213886799
Kushenol C
TN4399
99119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan
Antifection
BACE
Beta-Secretase
NF-κB
ROS
SGLT
HIT213885907
Isocudraniaxanthone A
TN4275
197447-26-0
Isocudraniaxanthone A may have antimalarial activity.
Antifection
Parasite
HIT213885275
5-Hydroxysophoranone
TN3124
90686-12-7
5-Hydroxysophoranone 从 Erythrina subumbrans 茎中提取,对恶性疟原虫具有高抗疟原虫活性 (IC50 = 2.5 μg/mL)。
Antibacterial
Antifection
Parasite
HIT104757725
Cedrelone
TN3616
1254-85-9
Cedrelone 是一种柠檬苦素类化合物,是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂,它能导致细胞周期停止。Cedrelone 具有杀虫活性,可抑制 P. saucia 的箭毒生长,并可抑制乳草蝽(Oncopeltus fasciatus)的蜕皮。Cedrelone具有抗肿瘤作用,对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。
Antifection
Apoptosis
MMP
HIT212083316
Terconazole
T2213
67915-31-5
Terconazole (Terazol 7) 是一种广谱抗真菌药物,用于研究阴道酵母菌感染。
Antifection
Antifungal
HIT213884389
Vasicinolone
TN5223
84847-50-7
Vasicinolone has anti-inflammatory, and antimicrobial activities.
Antibacterial
Antifection
HIT214316198
Beta-Solamarine
TN5034
3671-38-3
Beta-Solamarine has antibacterial activity.
Antibacterial
Antifection
HIT212665680
Marmin
TN1913
14957-38-1
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.
Antifection
Calcium Channel
Histamine Receptor
HIT213884953
Cleroindicin F
TN3680
189264-47-9
Cleroindicin F shows cytotoxic activity against some human cancer cells. Cleroindicin F and apigenin in the ethyl acetate extract provide scientific support to the traditional use of the leaves of C. splendens for the treatment of infections, wounds and o
Antibacterial
Antifection
HIT212665352
Cimigenol-3-one
TN1497
31222-32-9
Cimigenol-3-one is a natural product from Calophyllum inophyllum.
Antifection
Others
HIT212665827
Primin
TN2101
15121-94-5
Primin 是存在于 Primula obconica 叶和茎毛状体中的天然产物,显示出抗菌和抗癌活性。
Antibacterial
Antifection
HIT214315860
Effusanin E
TN3922
76470-15-0
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .
Antifection
Caspase
COX
NF-κB
PARP
HIT214316095
Pachyaximine A
TN4731
128255-08-3
Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS
Antibacterial
Antifection
HIT104664785
Paederoside
T3S0872
20547-45-9
Paederoside 是从Paederia pertomentosa 分离的一种单萜 S-甲基硫代碳酸酯。它抑制 Epstein-Barr 病毒的激活,有抗肿瘤促进作用。
Antifection
Antiviral
HBV
HIT213886966
Tagitinin F
TN5092
59979-57-6
Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.
Antifection
NF-κB
HIT213885899
Lycorenine
T2S1727
477-19-0
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
Antibacterial
Antifection
HIT213885172
Barbinervic acid
TN3490
64199-78-6
Barbinervic acid shows anti-bacteria activity (IC50 = 0.098 g x LU(-1), IC50 = 0.27 g x L(-1)) against SA and ESBLs-SA respectively.
Antifection
Glutaminase
HIT213884937
Atalantoflavone
TN3465
119309-02-3
Atalantoflavone shows urease inhibitory potential. It displays weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3.
Antifection
Parasite
HIT213884259
(-)-Corypalmine
TN3714
6018-40-2
Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.
Antibacterial
Antifection
HIT213886981
Tagitinin A
TN5091
59979-61-2
Tagitinin A (肿柄菊内酯 A)是一种天然的倍半萜内酯化合物,作为过氧化物酶体增殖物激活受体α/γ(PPARα/PPARγ)的双重激动剂,在糖尿病研究中发挥抗高血糖和抗高血脂作用。Tagitinin A 能够直接结合PPARγ配体结合域(IC50=55 μM),也能刺激PPARα依赖性SULT2A1基因启动子的转录激活。作为植物毒素时Tagitinin A对小麦胚芽鞘的生长有显著的抑制作用。
Antifection
PPAR
HIT213885609
Corymbosin
TN3713
18103-41-8
Corymbosin shows significant antiviral activity.
Antifection
Antifungal
HIT213886024
Moracin D
TN4581
69120-07-6
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open a new avenue in the treatment of tumerigenesis.
Antifection
Antifungal
Apoptosis
c-Myc
COX
TNF
HIT213884589
Artoheterophyllin B
TN3456
1174017-37-8
Artoheterophyllin B has antiplasmodial activity.
Antifection
Parasite
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