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化合物库
Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
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Parasite
Penicillin-binding protein (PBP)
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Reverse Transcriptase
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信号通路
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Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT100065449
Protoplumericin A
TN4834
80396-57-2
Protoplumericin A displays distinct activity against some pathogenic bacteria and fungi.
Antifection
HIT214316019
Macrocarpal H
TN4478
179388-53-5
Macrocarpal H has anti-glucosyltransferase, and anti-bacterial activities.
Antifection
Others
HIT213885396
3,4,5-Trimethoxyphenyl-(6-O-galloyl)-O-beta-D-glucopyranoside
TN2867
109206-94-2
3,4,5-Trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside exhibits in vitro antiplasmodial activity.
Antifection
HIT212525009
3,4,5-Trimethoxycinnamyl alcohol
TN2866
30273-62-2
3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities.
Antifection
HIT214315860
Effusanin E
TN3922
76470-15-0
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .
Antifection
Caspase
COX
NF-κB
PARP
HIT214435492
L-I-OddU
T61080
207920-87-4
L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM.
Antifection
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Others
HIT103788172
NIBR189
T7156
1599432-08-2
NIBR189是 EBI2(GPR183)小分子拮抗剂(IC50:11 nM)。
Antifection
EBI2/GPR183
HIT213884218
Altholactone
TN3404
65408-91-5
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis via oxidative stress, including bladd
Akt
Antifection
Bcl-2 Family
Caspase
p38 MAPK
p53
ROS
HIT213884966
2,3,24-Trihydroxyolean-12-en-28-oic acid
TN2686
150821-16-2
2α,3α,24-Trihydroxyolean-12-en-28-oic acid, a triterpenoid phytoalexin, isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia), shows antifungal activity against the fungus mentioned.
Antifection
HIT214315951
Homaloside D
TN4218
149155-19-1
Homaloside D has antiplasmodial activity.
Antifection
Parasite
HIT213884941
Clauszoline M
TN3674
187110-72-1
Clauszoline M shows a significant anti-tuberculosis activity.
Antifection
HIT213884259
(-)-Corypalmine
TN3714
6018-40-2
Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.
Antibacterial
Antifection
HIT214315759
Caesalmin B
TN3563
352658-23-2
Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
Antibiotic
Antifection
HIT104664785
Paederoside
T3S0872
20547-45-9
Paederoside 是从Paederia pertomentosa 分离的一种单萜 S-甲基硫代碳酸酯。它抑制 Epstein-Barr 病毒的激活,有抗肿瘤促进作用。
Antifection
Antiviral
HBV
HIT213886056
2-Methoxyphenalen-1-one
TN2774
51652-39-2
2-Methoxy-1H-phenalen-1-one (2-Methoxyphenalen-1-one) displays significantly enhanced activity against Mycosphaerella fijiensis in comparison with other phenylphenalenones.
Antifection
HIT213885388
Stigmastane-3,5,6-triol
TN5067
20835-91-0
Stigmastane-3,5,6-triol and derivatives could be used for preparing antiviral medicine.
Antifection
HIT213884224
Arjunic acid
T4131
31298-06-3
Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL.
Antifection
COX
HIT214316121
Platycoside A
TN4804
209404-00-2
Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice.
Antifection
HIT213886292
Nervogenic acid
TN4650
17622-86-5
Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.
Antibacterial
Antifection
HIT214315543
20-Deoxocarnosol
TN2798
94529-97-2
20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity.
Antifection
ROS
HIT213884834
Cerbinal
TN3626
65597-42-4
Cerbinal 是一种天然化合物,来源于非洲非洲菊的草本植物。它具有杀虫活性,是一种潜在的新型害虫防治剂。
Antifection
Antifungal
HIT213885579
Goniodiol
TN4159
96422-52-5
(+)-Goniodiol and 7-epi-(+)-Goniodiol show high antibacterial activity (MIC, 3.1 mM) against Yersinia intermedia.
Antifection
HIT213886981
Tagitinin A
TN5091
59979-61-2
Tagitinin A (肿柄菊内酯 A)是一种天然的倍半萜内酯化合物,作为过氧化物酶体增殖物激活受体α/γ(PPARα/PPARγ)的双重激动剂,在糖尿病研究中发挥抗高血糖和抗高血脂作用。Tagitinin A 能够直接结合PPARγ配体结合域(IC50=55 μM),也能刺激PPARα依赖性SULT2A1基因启动子的转录激活。作为植物毒素时Tagitinin A对小麦胚芽鞘的生长有显著的抑制作用。
Antifection
PPAR
HIT213885172
Barbinervic acid
TN3490
64199-78-6
Barbinervic acid shows anti-bacteria activity (IC50 = 0.098 g x LU(-1), IC50 = 0.27 g x L(-1)) against SA and ESBLs-SA respectively.
Antifection
Glutaminase
HIT212665352
Cimigenol-3-one
TN1497
31222-32-9
Cimigenol-3-one is a natural product from Calophyllum inophyllum.
Antifection
Others
HIT213123687
Gancaonin G
TN4097
126716-34-5
Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.
Antibacterial
Antifection
HIT213886603
1,2-Dihydrotanshinone
TN2485
77769-21-2
1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Antifection
DNA/RNA Synthesis
HIT213886024
Moracin D
TN4581
69120-07-6
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open a new avenue in the treatment of tumerigenesis.
Antifection
Antifungal
Apoptosis
c-Myc
COX
TNF
HIT213885275
5-Hydroxysophoranone
TN3124
90686-12-7
5-Hydroxysophoranone 从 Erythrina subumbrans 茎中提取,对恶性疟原虫具有高抗疟原虫活性 (IC50 = 2.5 μg/mL)。
Antibacterial
Antifection
Parasite
HIT213885392
6-Acetonyl-N-methyl-dihydrodecarine
TN3151
1253740-09-8
6-Acetonyl- N -methyl-dihydrodecarine has mosquito larvicidal activity against the malaria vector Anopheles gambiae.
Antifection
Monoamine Oxidase
HIT213886504
Isoboonein
TN4267
99946-04-0
Isoboonein exhibits significant antitumor and antibacterial activity.
Antifection
HIT213885609
Corymbosin
TN3713
18103-41-8
Corymbosin shows significant antiviral activity.
Antifection
Antifungal
HIT213886610
Danshenxinkun D
TMA0395
98873-76-8
Danshenxinkun D has antituberculosis H_(37)Rv activity in vitro.
Antifection
Dopamine Receptor
HIT214315685
Agatharesinol acetonide
TN3355
800389-33-7
Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM).
Antifection
HIT213840672
Kamebanin
TN4375
39388-57-3
Kamebanin 是一种天然二萜类化合物,具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。
Antifection
HIT214316198
Beta-Solamarine
TN5034
3671-38-3
Beta-Solamarine has antibacterial activity.
Antibacterial
Antifection
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