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化合物库
Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
Influenza Virus
Integrase
Parasite
Penicillin-binding protein (PBP)
RSV
Reverse Transcriptase
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信号通路
微生物学
Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT220772288
14-O-Acetylindolactam V
TN11318
91403-61-1
14-O-Acetylindolactam V 能够诱导早期 Epstein-Barr 病毒抗原的表达。
Antifection
HIT212665338
Cerebroside B
TN1481
88642-46-0
Cerebroside B1b has antiulcerogenic activity.
Antifection
Antifungal
HIT213885235
1(10)-Aristolen-2-one
TN2475
28398-06-3
1(10)-Aristolen-2-one has antifungal activity.
Antifection
HIT213887501
Methyl lucidenate L
TN5980
110267-46-4
Methyl lucidenate L 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5980,CAS号为 110267-46-4。
Antifection
HIT218909663
Lobucavir
T200820
127759-89-1
Lobucavir (BMS-180194; SQ 34514)为一种抗病毒核苷类似物,其具备广谱活性,效力涵盖HBV、HIV/AIDS以及各类型疱疹病毒(α、β、γ),包括CMV、单纯疱疹病毒、水痘带状疱疹病毒及Epstein-Barr病毒。
Antifection
EBV
HBV
HIV Protease
Nucleoside Antimetabolite/Analog
Virus Protease
HIT212666646
Altenuene
TN3401
29752-43-0
Altenuene 是一种霉菌毒素,经常出现在被链格孢属真菌侵染的食物和饲料中。 Altenuene 表现出对金黄色葡萄球菌的中等活性。 Altenuene 还表现出对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 的细胞毒活性。
Antifection
HIT213884991
1-Methoxyberberine
TN2548
29133-52-6
1-Methoxyberberine chloride is a potential antifungal agent.
Antifection
Antifungal
HIT213885287
Eucalyptin
TN4023
3122-88-1
Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A exhibits potent inhibition on HGF/c-M
Antifection
HIT213884831
Lupeol caffeate
TN4462
103917-26-6
Lupeol caffeate has anti-malarial activity.
Antifection
HIT213887114
Vitexolide D
TN5245
1788090-69-6
Vitexolide D shows moderate antibacterial activity against a panel of 46 Gram-positive strains. It also shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 uM).
Antifection
HIT214316159
Swietemahalactone
TN5082
1514669-21-6
Swietemahalactone exhibits antibacterial activity.
Antibacterial
Antifection
HIT213885041
Isolupalbigenin
TN4308
162616-70-8
Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
Antifection
NO Synthase
HIT104757725
Cedrelone
TN3616
1254-85-9
Cedrelone 是一种柠檬苦素类化合物,是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂,它能导致细胞周期停止。Cedrelone 具有杀虫活性,可抑制 P. saucia 的箭毒生长,并可抑制乳草蝽(Oncopeltus fasciatus)的蜕皮。Cedrelone具有抗肿瘤作用,对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。
Antifection
Apoptosis
MMP
HIT213886724
2,3-Dihydrohinokiflavone
TN2697
34292-87-0
2,3-Dihydrohinokiflavone 是基质金属蛋白酶 (MMP) 基因表达的抑制剂,对利什曼原虫具有很强的活性,IC50 为 1.6 μM。
Antifection
MMP
Parasite
HIT213886966
Tagitinin F
TN5092
59979-57-6
Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.
Antifection
NF-κB
HIT213885019
Cryptofolione
TN3721
160098-78-2
Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp.
Antifection
HIT213884937
Atalantoflavone
TN3465
119309-02-3
Atalantoflavone shows urease inhibitory potential. It displays weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3.
Antifection
Parasite
HIT214316095
Pachyaximine A
TN4731
128255-08-3
Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS
Antibacterial
Antifection
HIT213885899
Lycorenine
T2S1727
477-19-0
Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
Antibacterial
Antifection
HIT214315749
Bullatantriol
TN3547
99933-32-1
Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.
Antifection
HIT213885907
Isocudraniaxanthone A
TN4275
197447-26-0
Isocudraniaxanthone A may have antimalarial activity.
Antifection
Parasite
HIT100065449
Protoplumericin A
TN4834
80396-57-2
Protoplumericin A displays distinct activity against some pathogenic bacteria and fungi.
Antifection
HIT214316019
Macrocarpal H
TN4478
179388-53-5
Macrocarpal H has anti-glucosyltransferase, and anti-bacterial activities.
Antifection
Others
HIT213885396
3,4,5-Trimethoxyphenyl-(6-O-galloyl)-O-beta-D-glucopyranoside
TN2867
109206-94-2
3,4,5-Trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside exhibits in vitro antiplasmodial activity.
Antifection
HIT213884389
Vasicinolone
TN5223
84847-50-7
Vasicinolone has anti-inflammatory, and antimicrobial activities.
Antibacterial
Antifection
HIT212525009
3,4,5-Trimethoxycinnamyl alcohol
TN2866
30273-62-2
3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities.
Antifection
HIT212665492
Garcinone C
TN1673
76996-27-5
Garcinone C 是一种从 Garcinia oblongifolia Champ 中提取的黄酮衍生物,具有抗炎、收敛和促进肉芽的活性。 Garcinone C 是一种 AChE 抑制剂,对某些癌症具有潜在的细胞毒性作用。
AChR
Antifection
ATM/ATR
CDK
Hedgehog/Smoothened
STAT
HIT214315860
Effusanin E
TN3922
76470-15-0
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .
Antifection
Caspase
COX
NF-κB
PARP
HIT214435492
L-I-OddU
T61080
207920-87-4
L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM.
Antifection
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Others
HIT103788172
NIBR189
T7156
1599432-08-2
NIBR189是 EBI2(GPR183)小分子拮抗剂(IC50:11 nM)。
Antifection
EBI2/GPR183
HIT213884218
Altholactone
TN3404
65408-91-5
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis via oxidative stress, including bladd
Akt
Antifection
Bcl-2 Family
Caspase
p38 MAPK
p53
ROS
HIT213884966
2,3,24-Trihydroxyolean-12-en-28-oic acid
TN2686
150821-16-2
2α,3α,24-Trihydroxyolean-12-en-28-oic acid, a triterpenoid phytoalexin, isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia), shows antifungal activity against the fungus mentioned.
Antifection
HIT214315951
Homaloside D
TN4218
149155-19-1
Homaloside D has antiplasmodial activity.
Antifection
Parasite
HIT213884941
Clauszoline M
TN3674
187110-72-1
Clauszoline M shows a significant anti-tuberculosis activity.
Antifection
HIT213884259
(-)-Corypalmine
TN3714
6018-40-2
Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.
Antibacterial
Antifection
HIT212665586
Isorhamnetin 3-glucoside-7-rhamnoside
TN1792
17331-71-4
An anti-oxidative composition containing isorhamnetin-3-glucoside-7-rhamnoside (IGR)isolated from Hippophae rhamnoides L. is provided to ensure antioxidative, antibacterial, and anti-cancer effect.
Antifection
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