Antifection

Lobucavir (BMS-180194; SQ 34514)为一种抗病毒核苷类似物，其具备广谱活性，效力涵盖HBV、HIV/AIDS以及各类型疱疹病毒（α、β、γ），包括CMV、单纯疱疹病毒、水痘带状疱疹病毒及Epstein-Barr病毒。

Altenuene 是一种霉菌毒素，经常出现在被链格孢属真菌侵染的食物和饲料中。 Altenuene 表现出对金黄色葡萄球菌的中等活性。 Altenuene 还表现出对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 的细胞毒活性。

L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM.

NIBR189是 EBI2（GPR183）小分子拮抗剂(IC50:11 nM)。

2α,3α,24-Trihydroxyolean-12-en-28-oic acid, a triterpenoid phytoalexin, isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia), shows antifungal activity against the fungus mentioned.

Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis via oxidative stress, including bladd

Corypalmine (IC50=128.0±10.5 uM) can inhibit prolyl oligopeptidase. (-)-Corypalmine shows inhibition activity against spore germination of some fungi.

Homaloside D has antiplasmodial activity.

Clauszoline M shows a significant anti-tuberculosis activity.

Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.

Paederoside 是从Paederia pertomentosa 分离的一种单萜 S-甲基硫代碳酸酯。它抑制 Epstein-Barr 病毒的激活，有抗肿瘤促进作用。

2-Methoxy-1H-phenalen-1-one (2-Methoxyphenalen-1-one) displays significantly enhanced activity against Mycosphaerella fijiensis in comparison with other phenylphenalenones.

Stigmastane-3,5,6-triol and derivatives could be used for preparing antiviral medicine.

Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS

Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.

Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。

Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.

3,4,5-Trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside exhibits in vitro antiplasmodial activity.

Atalantoflavone shows urease inhibitory potential. It displays weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3.

Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression .

3,4,5-Trimethoxycinnamyl alcohol shows significant antimicrobial and cytotoxic activities.

Isoboonein exhibits significant antitumor and antibacterial activity.

Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL.

Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.

Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice.

20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity.

1-Methoxyberberine chloride is a potential antifungal agent.

Swietemahalactone exhibits antibacterial activity.

Isocudraniaxanthone A may have antimalarial activity.

Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A exhibits potent inhibition on HGF/c-M

Lupeol caffeate has anti-malarial activity.

Macrocarpal H has anti-glucosyltransferase, and anti-bacterial activities.

Protoplumericin A displays distinct activity against some pathogenic bacteria and fungi.

Vitexolide D shows moderate antibacterial activity against a panel of 46 Gram-positive strains. It also shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 uM).

Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp.

Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open a new avenue in the treatment of tumerigenesis.