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化合物库
Antifection
Anti-infection
Antibacterial
Antibiotic
Antifection
Antifungal
Beta-lactamase
CCR
EBV
Enterovirus
GluCls
HBV
HCV Protease
HIV Protease
HSV
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Integrase
Parasite
Penicillin-binding protein (PBP)
RSV
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信号通路
微生物学
Antifection
Antifection
感染是病原体入侵组织、繁殖以及宿主组织对感染源及其产生的毒素的反应。抗感染药物包括抗生素、抗真菌药物、抗原生动物药物和抗病毒药物。
HIT213884831
Lupeol caffeate
TN4462
103917-26-6
Lupeol caffeate has anti-malarial activity.
Antifection
HIT212665338
Cerebroside B
TN1481
88642-46-0
Cerebroside B1b has antiulcerogenic activity.
Antifection
Antifungal
HIT213886603
1,2-Dihydrotanshinone
TN2485
77769-21-2
1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Antifection
DNA/RNA Synthesis
HIT214316094
Oplopanone
TN4717
1911-78-0
Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.
Antifection
HIT212665398
Decarine
TN1556
54354-62-0
Decarine has high antibacterial activity against mycobacterial, gram-positive and gram-negative bacteria, and low cytotoxicity towards human macrophages.Decarine inhibits fMLP/CB-induced elastase release with IC(50) values < or = 5.53 microg/mL.
Antifection
HIT106687580
Methyl 4-Hydroxyphenylacetate
TN1436
14199-15-6
Methyl 4-Hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV).
Antifection
HIT103275702
3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid
TN2849
477873-63-5
2-O-beta-d-Glucosyloxy-4-methoxybenzenepropanoic acid[3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid] exhibits glutathione S-transferase (GST) inhibitory and antifungal activities.
Antifection
HIT213884672
(2S)-7,4'-Dihydroxy-3'-prenylflavan
TN3214
376361-96-5
7,4'-Dihydroxy-3'-prenylflavan has antibacterial activity.
Antifection
HIT101565811
5,6,7-Trimethoxycoumarin
TN3080
55085-47-7
5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp larvae. 5,6,7-Trimethoxycoumarin can improve gastroprotective effects, and it has low toxicity
Antifection
Cytochromes P450
HIT102880213
Licoarylcoumarin
TN4433
125709-31-1
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
Antifection
cAMP
HIV Protease
HIT214314594
Saikosaponin I
TN2172
103629-71-6
Saikosaponin I shows strong inhibition activity against influenza virus WSN33.
Antifection
HIT213884656
11,13-Dihydroivalin
TN2579
150150-61-1
11,13-Dihydroivalin是一种天然产物,属于菊科艾纳香属,其产品编号为 TN2579,CAS号为 150150-61-1。11,13-Dihydroivalin可用作对照参考。
Antifection
HIT213884722
2-Acetoxy-3-deacetoxycaesaldekarin E
TN2747
18326-06-2
2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
Antifection
HIT212665128
2,3,8-Tri-O-methylellagic acid
TN1203
1617-49-8
2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.
Antifection
HIT213887340
Prehelminthosporol
TN4822
1619-13-2
Prehelminthosporol is a phytotoxin, it may play an important role in pathogenesis by killing or weakening plant cells in advance of the growing hyphae and facilitating nutrient uptake and further growth of the fungus in plant tissue.
Antifection
HIT213884307
Khellactone
TN4387
24144-61-4
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.
Antifection
HIT213885566
(+/-)-Sigmoidin A
TN5020
176046-04-1
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
Antifection
Lipoxygenase
HIT107457200
(+/-)-Vestitol
TN5227
56701-24-7
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries. Vestitol inhibits neutrophils migration
Antifection
CXCR
NOS
HIT213885876
Vestitol
TN5228
35878-41-2
Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemical barrier against the intrusion of the parasite.
Antifection
HIT213884420
Agrimonolide 6-O-glucoside
TN3363
126223-29-8
Agrimonolide-6-O-glucopyranoside has antimicrobial activity.
Antifection
HIT214315889
Erythrabyssin II
TN3995
77263-06-0
Erythrabyssin II actives against several strains of Staphylococcus and Streptococcus with an MIC range of 0.78-1.56 microg/ml. It inhibits bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM).
Antifection
HIT219228903
Ganolactone A
TN8599
173268-82-1
Ganolactone A 是一种天然产物,可用作天然产物对照品,用于生命科学相关领域的研究,其产品编号为 TN8599。
Antifection
HIT214315532
Jatrophane 4
TN2728
210108-88-6
Jatrophane 3 (2R*,3R*, 4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,14-triacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxy-9-nicotinoyloxyjatropha-6(17),11E-diene) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera), with an EC50 value of 0.43 ug/cm2.
Antifection
Endogenous Metabolite
HIT214316278
Zeorin
TN5279
22570-53-2
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release.
Antibacterial
Antifection
Antifungal
ATPase
Calcium Channel
Histamine Receptor
Others
HIT213884500
Kaempferol-7,4'-dimethyl ether
TN2898
15486-33-6
Kaempferol-7,4'-dimethyl ether 是从 Zingiber phillipseae 的根茎中分离得到的,对金黄色葡萄球菌和大肠杆菌具有抗氧化活性,MIC 分别为 200 和 225 μg/ml。
Antifection
Antioxidant
Phosphatase
HIT218851900
CEF14, EBV Rta Protein (28-37)
TP1507
216862-58-7
CEF14, EBV Rta Protein (28-37), is the HLA A24-restricted epitope from the Epstein-Barr virus Rta Protein (28-37).
Antifection
HIT212665340
Cheilanthifoline
TN1484
483-44-3
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.
Antifection
NF-κB
Parasite
HIT212665402
Dehydroglaucine
TN1561
22212-26-6
Dehydroglaucine is an acetylcholinesterase inhibitor, it shows antimicrobial activity against Staphylococcus aureus, Mycobacterium smegmatis, Candida albicans, and Aspergillus niger.
Antibacterial
Antifection
HIT212671126
BRL44385
T10615
114778-60-8
BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).
Antifection
HSV
HIT213885835
Lipiferolide
TN4443
41059-80-7
Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.
Antifection
Parasite
Telomerase
Transferase
HIT103501181
Longistylin C
TN4449
64125-60-6
Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine
Antifection
HIT100069072
Carabrone
TN1114
1748-81-8
Carabrone 是分离自Carpesium abrotanoides 果实的一种倍半萜,表现出显著抗肿瘤活性和抗菌活性,如灰霉病菌Botrytis cinerea,炭疽病菌Colletotrichum lagenarium 和禾白粉菌Erysiphe graminis。
Antibacterial
Antifection
HIT213886036
Minumicrolin
TN4570
88546-96-7
Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity.
Antifection
HSV
Others
HIT213885091
Isopimaric acid
TN4319
5835-26-7
Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
Antifection
Potassium Channel
HIT213840686
Trichorabdal A
TN5173
85329-59-5
Trichorabdal A 是一种二萜化合物,分离自 Rabdosia trichocarpa,抗肿瘤作用强大。
Antibacterial
Antifection
HIT213886290
Dehydroabietinol
TN3790
3772-55-2
Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫,IC50为26-27 μM.
Antifection
Syk
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